scholarly journals Thyroid stimulating hormone isn’t a sensitive indicator of iodine nutritional status in schoolchildren

2016 ◽  
Vol 14 (3) ◽  
pp. 350
Author(s):  
Renata De Oliveira Campos ◽  
Joaquim Custódio Silva Júnior ◽  
Elton Estrela Ramos
Keyword(s):  
Public Schools ◽  
Nutritional Status ◽  
Filter Paper ◽  
Urinary Iodine ◽  
Iodine Concentration ◽  
Thyroid Stimulating Hormone ◽  
Urinary Iodine Concentration ◽  
Iodine Nutrition ◽  
Cross Sectional ◽  
Stimulating Hormone

<p><strong><em>Introduction:</em></strong><em> iodine deficiency </em><em>disorders (IDD)</em><em> </em><em>are most common cause of preventable brain damage, mental retardation and stunted growth in children</em><em> worldwide. Several indicators are complementary to urinary iodine concentration (UIC) for assessing iodine nutritional status, as thyroid size, thyroglobulin (Tg) and thyroid stimulating hormone (TSH) concentrations in the blood.</em><strong><em> Objective:</em></strong><em> </em><em>analyze TSH in filter paper blood values and correlate with UIC in schoolchildren from public school at state of Bahia, Brazil</em><em>. <strong>Methodology: </strong></em><em>cross-sectional study was conducted in 880 schoolchildren aged 6-14 years, randomly selected, of public schools in five cities of four micro-regions of Bahia between October 2013 and September 2014. TSH was analyzed in filter-paper blood and UIC were measured by adapted Sandell-Kolthoff reaction. </em><strong><em>Results:</em></strong><em> 880 blood samples on filter-paper were analyzed for TSH. The reference range previously established is 0.72 to 6.0 </em><em>μ</em><em>UI/mL</em><em>. Results of this research TSH dosage ranged from 0.24 </em><em>μ</em><em>IU/L to</em><em> 7.71 </em><em>μ</em><em>IU/L,</em><em> with a mean of 1.01±0.55 </em><em>μ</em><em>UI/L</em><em> and median 0.89 </em><em>μ</em><em>UI/L</em><em>. Only one child presented TSH greater than 6.0 (7.71 </em><em>μ</em><em>IU/L); however, results of urinary iodine were consistent with a more than adequate nutrition iodine (243.70</em><em>μ</em><em>g/L). There’ no correlation between TSH and UIC (r= 0.115; p= 0.002)</em><em>.</em><em> </em><strong><em>Conclusion:</em></strong><em>  in the present study, schoolchildren showed low values of TSH, but the mean UIC was indicative of adequate iodine nutrition</em><em>.</em><em></em></p>

scholarly journals Iodine nutrition status in clinically euthyroid pregnant women attending in BSMMU

2016 ◽  
Vol 9 (1) ◽  
pp. 38
Author(s):  
Md. Anowar Hossain ◽  
M. Abul Hasanat ◽  
Murshed Ahamed Khan ◽  
Jobaida Naznin ◽  
Kazi Ashraful Alam ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Urinary Iodine ◽  
Iodine Content ◽  
Iodine Concentration ◽  
Nutrition Status ◽  
Urinary Iodine Concentration ◽  
Digestion Method ◽  
Iodine Nutrition ◽  
Cross Sectional ◽  
Nutritional Problem

<p><strong>Background:</strong> Iodine deficiency disorders (IDD) are common nutritional problem globally. All groups of people are affected by it, but the pregnant women and their neonates are most vulnerable.</p><p><strong>Objectives:</strong> This study was carried out to see the iodine status of pregnant women using median urinary iodine concentration (MUI) as a measure of outcome. Methods: This cross sectional observational study assessed the MUI in casual urine samples from 225 pregnant women (75 pregnants from each trimester) and 75 non-pregnant healthy controls. The urinary iodine content was estimated in urine sample using the method of Dunn et al. with the modification of Sandell &amp; Kolthoff (wet digestion method).</p><p><strong>Results:</strong> Median value of urinary iodine in pregnant women was 48.21Ug/L compared to 52.27</p>

scholarly journals Iodine Nutritional Status and Related Factors among Chinese School-Age Children in Three Different Areas: A Cross-Sectional Study

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1404
Author(s):  
Xiaoyun Shan ◽  
Changqing Liu ◽  
Xiaoyan Luo ◽  
Yan Zou ◽  
Lichun Huang ◽  
...  
Keyword(s):  
Vitamin A ◽  
Nutritional Status ◽  
Iodine Deficiency ◽  
Urinary Iodine ◽  
Thyroid Stimulating Hormone ◽  
School Age Children ◽  
Urinary Iodine Concentration ◽  
School Age ◽  
Related Factors ◽  
Cross Sectional

We evaluated the iodine nutritional status and related factors among school-age children based on the 2016 National Nutrition and Health Surveillance of Children and Lactating Women; 3808 children from Hebei, Guangxi, and Zhejiang province were included in the study. Urinary iodine concentration (UIC), thyroid-stimulating hormone (TSH), body mass index (BMI), vitamin A (VA), and vitamin D (VD) were measured. The abnormal rate of UIC and TSH were assessed. Relationships between UIC/TSH and the possible factors were analyzed. The overall median UIC was 185.14 µg/L, and the median UIC of children aged 8–10 was 164.60 µg/L. Prevalence of iodine deficiency and excess was 13.84% and 14.36%, respectively, and 12.87% of children showed TSH excess. UIC, as well as the abnormal rates of iodine deficiency (ID) and TSH, were significantly different among the three provinces. The median UICs and excess rates increased with age, reaching 211.45 µg/L and 21.35% at age of 14~, while TSH showed the opposite trend. Overweight children tended to have lower UIC and higher TSH. Higher UIC and TSH were found in VA sufficient group (p < 0.01). Further, the VD deficient group had a higher TSH compared to the sufficient group (p < 0.01). Moreover, UI and TSH distribution was obviously different among different vitamin A/D status (p < 0.05). Although the median UIC of school-age children was optimal, there were pockets of inadequate and excessive UI in the three provinces. Compared to the national IDD monitoring results in 2014, the iodine nutritional status of children was greatly improved. Considerations of region, age, BMI, VA, or VD are needed in the future iodine evaluation and surveillance.

scholarly journals Iodine concentration and prevalence of thyroid disease in older people after salt iodization in Turkey

2021 ◽  
Vol 27 (2) ◽  
pp. 151-158
Author(s):  
Volkan Atmis ◽  
Buket Bülbül ◽  
Remzi Bahşi ◽  
Mesut Gümüşsoy ◽  
Ahmet Yalçin ◽  
...  
Keyword(s):  
Older People ◽  
Thyroid Disease ◽  
Demographic Data ◽  
Urinary Iodine ◽  
Iodine Concentration ◽  
Needle Aspiration ◽  
Thyroid Stimulating Hormone ◽  
Urinary Iodine Concentration ◽  
Salt Iodization ◽  
Stimulating Hormone

Background: Iodine uptake is a main factor affecting thyroid disease. In Turkey, mandatory salt iodization began in 1999–2000. Aims: This study in 2009 determined the prevalence of thyroid diseases in older people in Mamak district, Ankara after iodization to ascertain if salt iodization alone is sufficient to reach adequate iodine levels in the older population. Methods: All Mamak residents ≥ 65 years were eligible for inclusion in the study. Demographic data and medical history were recorded. All participants had a thyroid ultrasound. Blood samples were taken to assess thyroid function and autoantibodies, and urine samples to assess iodine concentration. Participants with low levels of thyroid stimulating hormone underwent scintigraphy to assess thyroid uptake. Fine-needle aspiration biopsy was done of nodules ≥ 1.5 cm where thyroid stimulating hormone was not suppressed. Results: Of 1200 eligible residents, 979 were included. Their mean age was 70.9 (standard deviation (SD) 5.7) years; 49.7% were women. Mean urinary iodine concentration was 98 (SD 81.29) µg/L. Goitre was found in 18.2% (89/487) of women and 6.7% (33/492) of men (P < 0.001) and 43.8% (428/979) had nodules. Subclinical hypothyroidism was found in 5.8% (57/979) of the participants, overt hyperthyroidism in 0.8% (8/979), subclinical hyperthyroidism in 2.2% (22/979) and T3 thyrotoxicosis in 0.3% (3/979). Toxic multinodular goitre and toxic adenoma caused 80% of hyperthyroidism cases. Biopsy detected no malignant pathology. Conclusion: After salt iodization, iodine levels have not yet reached favourable levels in older people. Iodization of salt seems insufficient to achieve these levels in older people; alternative iodine supplementation should be considered.

scholarly journals Iodine deficiency in pregnant women and neonates in Thailand

2007 ◽  
Vol 10 (12A) ◽  
pp. 1602-1605 ◽  
Author(s):  
Rajata Rajatanavin
Keyword(s):  
Rural Areas ◽  
Whole Blood ◽  
Urinary Iodine ◽  
Iodine Concentration ◽  
Thyroid Stimulating Hormone ◽  
Urinary Iodine Concentration ◽  
Serum Samples ◽  
Iodine Nutrition ◽  
Cord Serum ◽  
District Hospitals

AbstractObjective: To present data on the relationship between the concentration of thyroid-stimulating hormone (TSH) in whole blood or serum from neonates and the concentration of iodine in their mother's urine collected at birth to contribute to the contention that the recommended iodine intake during pregnancy should be increased.Design and Setting: Data were provided by current programmes of neonatal screening of congenital hypothyroidism in Bangkok and rural areas of Thailand.Subjects: A total of 5144 cord serum samples were collected in 2003 and measured for TSH concentrations. Paired samples of blood and urine were collected in 2000 from 203 infants and their mothers and from 1182 infant-mother pairs in 2002-03 in six rural provinces. Iodine was measured in the urine and TSH was measured in cord serum.Results: The urinary iodine concentration of mothers in rural Thailand is adequate, with a median of 103 μg l-1. However, in 2000, the median urinary iodine concentration of mothers in Bangkok was only 85 μg l-1. The concentration of TSH in whole blood collected on filter paper from neonates was not sensitive enough to be used as a monitoring tool for iodine nutrition in the neonates, as there was no relationship with the concentration of iodine in the urine of the children's mothers. This was in contrast to the concentration of TSH in serum collected from cord blood.Conclusions: Several conclusions were drawn from this data: 1) Neonatal TSH screening using whole blood collected from a heel prick at 3 days of age is not sensitive enough to assess the iodine nutrition of neonates; 2) Neonatal TSH screening using cord sera can be used to assess iodine nutrition in neonates; 3) The optimum median maternal urinary iodine concentration in Thailand appears to be 103 μg l-1; 4) The criteria proposed by WHO, UNICEF, and ICCIDD to assess iodine nutrition using data on neonatal TSH concentrations should be reassessed; and 5) Neonatal TSH screening can be effectively performed by collecting cord serum in district hospitals in Thailand.

scholarly journals Thyroid function and thyroglobulin level in iodine deficient children of eastern Nepal

2020 ◽  
Author(s):  
Saroj Kunwar ◽  
Saroj Khatiwada ◽  
Basanta Gelal ◽  
Saroj Thapa ◽  
Gaurishankar Shah ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Urinary Iodine ◽  
Iodine Concentration ◽  
Ammonium Persulfate ◽  
Thyroid Stimulating Hormone ◽  
Overt Hypothyroidism ◽  
Urinary Iodine Concentration ◽  
Free Triiodothyronine ◽  
Iodine Nutrition ◽  
Serum Thyroglobulin

Abstract Objective: Both iodine deficiency and excess can negatively impact thyroid function. The present study was conducted to assess iodine nutrition among children and thyroid function in iodine deficient children. Results: A total of 1012 school aged children (6-14 years) from several schools of Udayapur district were enrolled initially for the assessment of urinary iodine concentration (UIC). Blood samples (n=83) were collected from a subgroup of children who had UIC<100 µg/L to measure serum thyroglobulin (Tg), thyroid stimulating hormone (TSH), free triiodothyronine (fT3) and free thyroxine (fT4). Serum UIC was measured by ammonium persulfate digestion method and Tg, TSH, fT4 and fT3 were measured by ELISA kits from Diametra Company. The prevalence of insufficient UIC (UIC<100 µg/L) was 11.1% in school children’s of Udayapur district. The median UIC was 236 µg/L. The mean fT3, fT4 and TSH among children with insufficient UIC were 2.55±0.43 pg/mL, 0.96±0.28 ng/dL and 3.60±1.44 mIU/L respectively. The Median Tg was 17.5 ng/mL. Overt hypothyroidism and subclinical hypothyroidism was seen in 6% and 3.6% cases with UIC<100 µg/L respectively.

scholarly journals Is it Necessary to Recommend Iodine Supplement to Pregnant Women Living in Areas with Adequate Iodine Intake?

2020 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Mahmood Sovid ◽  
Maryam Bahmani ◽  
Alamtaj Aamsami
Keyword(s):  
Pregnant Women ◽  
Significant Proportion ◽  
Urinary Iodine ◽  
Iodine Concentration ◽  
Iodine Intake ◽  
Thyroid Stimulating Hormone ◽  
Urinary Iodine Concentration ◽  
Cross Sectional ◽  
Group 2 ◽  
Group 1

Background: Iodine need is increased during pregnancy and its deficiency can lead to complications in mother and fetus. The latest international guidelines have recommended a higher intake of iodine. Iran has implemented a national salt iodization program since 25 years ago, and the general population is iodine-sufficient. However, recent studies have shown that a significant proportion of pregnant women have urinary iodine concentration (UIC) below the recommended range of 150 - 250 µg/L. Based on the results of these studies, iodine supplement during pregnancy is widely used, but this practice is controversial. Objectives: The aim of this study was to evaluate the necessity for iodine supplementation in pregnant women living in Shiraz, an iodine-replete area. Methods: In this cross-sectional case-control study, UIC and thyroid-stimulating hormone of 174 pregnant women taking 150 µg/day iodine (group 1) were compared with 124 pregnant women not taking the supplement (group 2). The proportion of women with UIC below the recommended level in each group was also determined. UIC of the women in different trimesters in each group was also investigated and compared. Results: Mean UIC in groups 1 and 2 was 175.71 ± 56.43 µg/Land 122.5 ± 44.37 µg/L and this difference was significant (P = 0.006). Also, 56% of women in group 2 and 24 % in group 1 had UIC below the recommended value (P < 0.01). Mean UIC in both groups decreased with advancing gestational age. In group 1, mean UIC remained in the recommended range, whereas in group 2, it decreased to less than 100 µg/L. Conclusions: In areas covered by the national salt iodine implementation program, it is necessary to recommend iodine supplement to pregnant women to prevent iodine insufficiency.

scholarly journals Iodine status and fish intake of Sudanese schoolchildren living in the Red Sea and White Nile regions

2012 ◽  
Vol 15 (12) ◽  
pp. 2265-2271 ◽  
Author(s):  
Izzeldin S Hussein ◽  
Yoeju Min ◽  
Kebreab Ghebremeskel ◽  
Abdelrahim M Gaffar
Keyword(s):  
Red Sea ◽  
Fish Consumption ◽  
Urinary Iodine ◽  
Iodine Content ◽  
Iodine Concentration ◽  
Urinary Iodine Concentration ◽  
Iodine Nutrition ◽  
Cross Sectional ◽  
Iodine Status ◽  
White Nile

AbstractObjectiveTo investigate iodine status and fish consumption of schoolchildren living in the Red Sea and White Nile regions of Sudan.DesignCross-sectional study to determine urinary iodine concentration, visible goitre rate, iodine content of salt and fish consumption.SettingPort Sudan (Red Sea) and Jabal Awliya (White Nile), Sudan.SubjectsTwo hundred eighty (n280) children aged 6–12 years (142 boys, 138 girls).ResultsThe median urinary iodine concentration in children from Port Sudan and Jabal Awliya was 553 and 160 μg/l, respectively. Goitre was detected in 17·1 % of children from Port Sudan but only in 1·4 % from Jabal Awliya, The salt samples from Port Sudan contained 150–360 mg iodine (KOI3)/kg salt, whereas those from Jabal Awliya had levels below the detection limit. Despite consuming salt devoid of iodine, children from Jabal Awliya had optimal iodine status. It is plausible that consumption of Nile fish from Jabal Awliya Reservoir, which is a good source of iodine and favoured by the locals, might have provided sufficient iodine. In contrast, children from Port Sudan were at higher risk of iodine-induced hyperthyroidism resulting from consumption of excessively iodised salt.ConclusionsThe findings of the study clearly demonstrated that (i) Sudan still has a problem with iodine nutrition and quality control and monitoring of salt iodisation and (ii) including fish in the diet could provide a sufficient amount of iodine for schoolchildren.

scholarly journals Comparison of iodine status pre- and post-mandatory iodine fortification of bread in South Australia: a population study using newborn thyroid-stimulating hormone concentration as a marker

2019 ◽  
Vol 22 (16) ◽  
pp. 3063-3072 ◽  
Author(s):  
Molla Mesele Wassie ◽  
Lisa N Yelland ◽  
Lisa G Smithers ◽  
Enzo Ranieri ◽  
Shao Jia Zhou
Keyword(s):  
Iodine Deficiency ◽  
Urinary Iodine ◽  
South Australia ◽  
Interrupted Time Series ◽  
Iodine Concentration ◽  
Thyroid Stimulating Hormone ◽  
Transitional Period ◽  
Urinary Iodine Concentration ◽  
Iodine Status ◽  
Stimulating Hormone

AbstractObjective:The present study aimed to evaluate the effect of mandatory iodine fortification of bread on the iodine status of South Australian populations using newborn thyroid-stimulating hormone (TSH) concentration as a marker.Design:The study used an interrupted time-series design.Setting:TSH data collected between 2005 and 2016 (n 211 033) were extracted from the routine newborn screening programme in South Australia for analysis. Iodine deficiency is indicated when more than 3 % of newborns have TSH > 5 mIU/l.Participants:Newborns were classified into three groups: the pre-fortification group (those born before October 2009); the transition group (born between October 2009 and June 2010); and the post-fortification group (born after June 2010).Results:The percentage of newborns with TSH > 5 mIU/l was 5·1, 6·2 and 4·6 % in the pre-fortification, transition and post-fortification groups, respectively. Based on a segmented regression model, newborns in the post-fortification period had a 10 % lower risk of having TSH > 5 mIU/l than newborns in the pre-fortification group (incidence rate ratio (IRR) = 0·90; 95 % CI 0·87, 0·94), while newborns in the transitional period had a 22 % higher risk of having TSH > 5 mIU/l compared with newborns in the pre-fortification period (IRR = 1·22; 95 % CI 1·13, 1·31).Conclusions:Using TSH as a marker, South Australia would be classified as mild iodine deficiency post-fortification in contrast to iodine sufficiency using median urinary iodine concentration as a population marker. Re-evaluation of the current TSH criteria to define iodine status in populations is warranted in this context.

scholarly journals Thyroid Function and Thyroglobulin Level in Iodine-Deficient Children of Eastern Nepal

2021 ◽  
Vol 9 (1) ◽  
pp. 75-78
Author(s):  
Saroj Kunwar ◽  
Saroj Khatiwada ◽  
Basanta Gelal ◽  
Saroj Thapa ◽  
Gaurishankar Shah ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Iodine Deficiency ◽  
Urinary Iodine ◽  
Iodine Concentration ◽  
Overt Hypothyroidism ◽  
Urinary Iodine Concentration ◽  
Free Triiodothyronine ◽  
Iodine Nutrition ◽  
Serum Thyroglobulin ◽  
Cross Sectional

Iodine deficiency during childhood affects physical and mental development. Iodine deficiency or excess both can negatively impact thyroid function. We conducted this study to assess iodine nutrition and thyroid function in children with insufficient urinary iodine concentration. A community-based cross-sectional study was conducted among the selected schools of Udayapur district. Urinary iodine concentration (UIC) was measured in 1012 school children (6-14 years). Based on UIC data, 83 blood samples were collected to measure serum thyroglobulin (Tg), thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), and free thyroxine (fT4). UIC was measured by ammonium persulfate digestion method, and Tg, TSH, fT4, and fT3 were measured using ELISA kits. The median UIE was 236 µg/L, and 11.1% of the children had insufficient UIC. The mean fT3, fT4, and TSH in children with insufficient UIC were 2.55±0.43 pg/mL, 0.96±0.28 ng/dL, and 3.60±1.44 mIU/L respectively. Among children with low UIC levels, the median Tg was 17.5 ng/mL. Overt hypothyroidism was seen in 6%, and subclinical hypothyroidism in 3.6%. The children had sufficient iodine nutrition, and the frequency of thyroid dysfunction was low among the children with insufficient UIC.

Sign in / Sign up

Export Citation Format

Share Document