scholarly journals In Vivo Immunological Activity in Fermentation with Black Rice Bran

2011 ◽  
Vol 24 (3) ◽  
pp. 273-281 ◽  
Author(s):  
Dong-Ju Kim ◽  
Su-Noh Ryu ◽  
Sang-Jun Han ◽  
Hwa-Young Kim ◽  
Jung-Hak Kim ◽  
...  
2020 ◽  
Vol 15 (7) ◽  
pp. 1934578X2093491
Author(s):  
Young Mi Park ◽  
Hak Yong Lee ◽  
Dong Yeop Shin ◽  
Yang Hee Lee ◽  
Ye Jin Yang ◽  
...  

Black rice bran extract (BRBE), containing various biologically active compounds, such as anthocyanin, has antioxidant activity and numerous pharmacological effects. Here, we aimed to confirm the immunostimulatory effects of BRBE in cyclophosphamide (CP)-induced immunosuppressed cells. Our results confirmed that BRBE exerted an immunostimulatory effect. In vitro, BRBE treatment enhanced cell proliferation, activity of natural killer cells and cytotoxic T lymphocytes, and production of CP-repressed cytokines, such as tumor necrosis factor-α, interferon-γ, interleukin (IL)-2, and IL-12, and immunoglobulins G and A in isolated splenocytes. Additionally, in vivo, BRBE treatment increased the number of immune cells, such as white blood cells, lymphocyte counts, mid-range absolute counts, and neutrophils in CP-induced immunosuppressed rats. Furthermore, BRBE increased the serum levels of abovementioned inflammatory cytokines and immunoglobulins in CP-induced immunosuppressed rats. In addition, BRBE protected against CP-mediated spleen and thymic tissue damage. Our findings suggest that BRBE could be potentially used as a component of functional food for immunity enhancement.


2015 ◽  
Vol 6 (6) ◽  
pp. 419-433
Author(s):  
M. El - Bana ◽  
M. El - Sayed ◽  
Sahar AbdEl- Hady

LWT ◽  
2007 ◽  
Vol 40 (10) ◽  
pp. 1732-1740 ◽  
Author(s):  
Jintana Wiboonsirikul ◽  
Shigeru Hata ◽  
Takuo Tsuno ◽  
Yukitaka Kimura ◽  
Shuji Adachi

2016 ◽  
Vol 15 (9) ◽  
pp. 837-845 ◽  
Author(s):  
Enny Purwati Nurlaili ◽  
Mary Astuti ◽  
Yustinus Marsono ◽  
Sri Naruki

Author(s):  
N M Wartini ◽  
L P Wrasiati ◽  
I A A Widnyani ◽  
G P G Putra ◽  
I M A S Wijaya

2003 ◽  
Vol 51 (24) ◽  
pp. 6953-6956 ◽  
Author(s):  
Mitsuo Miyazawa ◽  
Teruo Oshima ◽  
Katsuya Koshio ◽  
Yumi Itsuzaki ◽  
Jun Anzai

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