The Sinergistic Effect of Black Rice Bran Extract and Glibenclamide on Protecting Renal, Hepatic, and Pancreatic Cells in Alloxan Induced Rats

Author(s):  
N M Wartini ◽  
L P Wrasiati ◽  
I A A Widnyani ◽  
G P G Putra ◽  
I M A S Wijaya

2018 ◽  
Vol 14 (1) ◽  
pp. 8-13
Author(s):  
Novita Sari ◽  
Arifah Sri Wahyuni

Black rice bran is one of processed foods derived from plants and has a decreasing effect of blood glucoselevels. Major component of anthocyanin in black rice bran that functions in lowering blood glucoseconcentration is cyanidin 3-glucoside. Fifteen male rats Sprague-Dawley strain were selected randomly anddivided into 5 groups with the same number in each groups. These groups were consisted of normal control,negative control, and black rice bran extract treatment with dose of 50, 100 and 200 mg/kg of bodyweight(b.w.). Each of them were induced to experience diabetes by alloxan 150 mg/kg of b.w. Measurement ofblood glucose levels was done by using visible spectrophotometer at 546 nm. The samples were collectedbefore and after alloxan injection, and after 4, 7, and 10 days later to observe the changes of blood glucoselevels. The results showed that black rice bran at 200 mg/kg of b.w. was able to lower the glucose levels,which amounted for 131,33 ± 8,08 mg/dL after 10 days of injection.


2017 ◽  
Vol 20 (9) ◽  
pp. 855-863 ◽  
Author(s):  
Soon Young Shin ◽  
Heon-Woong Kim ◽  
Hwan-Hee Jang ◽  
Yu-Jin Hwang ◽  
Jeong-Sook Choe ◽  
...  

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Mahdi Jufri ◽  
Afifah Vardhani ◽  
Erni Purwaningsih

Background: Ultraviolet exposure is an extrinsic factor to initiate melanogenesis, the process of melanin formation in the skin. Nowadays, natural ingredients tend to be more prevalent in cosmetic formulations due to consumers’ concern about synthetic ingredients and the risks they may represent for human health. Rice bran, the outer layer of a rice grain, can be utilized as a skin-lightening agent. Objectives: This study aimed to determine the efficacy of a lotion containing black rice bran (Oryza sativa L. indica) ethanolic extract as a skin lightening agent. Methods: The black rice bran ethanolic extract was formulated into oil in water (o/w) lotion. In this study, 34 women applied the lotion at one side of the forearm and base placebo lotion as control at the other side of forearm. The results were tested with a paired t-test by GraphPad Prism 8.3.0 software. Results: There was a significant decrease in the melanin index and erythema index in the forearm with a lotion containing black rice bran extract (P-value < 0.0001). Conclusions: The lotion containing 10% black rice bran extract was effective as a skin lightener because it effectively reduced skin melanin production when applied topically.


2015 ◽  
Vol 6 (6) ◽  
pp. 419-433
Author(s):  
M. El - Bana ◽  
M. El - Sayed ◽  
Sahar AbdEl- Hady

LWT ◽  
2007 ◽  
Vol 40 (10) ◽  
pp. 1732-1740 ◽  
Author(s):  
Jintana Wiboonsirikul ◽  
Shigeru Hata ◽  
Takuo Tsuno ◽  
Yukitaka Kimura ◽  
Shuji Adachi

Author(s):  
Sukrasno Sukrasno ◽  
Slamet Tuty ◽  
Irda Fidrianny

Objectives: The objectives of this research were to evaluate antioxidant activity from different polarities rice bran extract of three varieties of rice using two methods of antioxidant testing which were FRAP (Ferric Reducing Antioxidant Power) and DPPH (2,2-diphenyl-1-picrylhydrazyl), and correlation of total phenolic, flavonoid and carotenoid content with their EC50 of FRAP and IC50 of DPPH antioxidant activities. Methods: Extraction was conducted by reflux using different polarity solvents. The extracts were evaporated using rotary evaporator. Determination of total phenolic, flavonoid and carotenoid content, antioxidant activities using FRAP and DPPH assays were performed by UV-visible spectrophotometry and its correlation with EC50 of FRAP capacities and IC50 of DPPH scavenging activities were analyzed by Pearson’s method. Results: Ethanolic rice bran extract of black rice showed the lowest EC50 of FRAP capacity 64.35 µg/ml and IC50 of DPPH scavenging activity 23.92 µg/ml. The highest phenolic content, flavonoid content and carotenoid content were also given by ethanolic rice bran extract of black rice. There were significantly negative correlation between total phenolic content and carotenoid content in rice bran extract of red rice and black rice with their IC50 of DPPH. Conclusions: All of rice bran extracts (except n-hexane rice bran extract of black rice and ethanolic rice bran extract of white rice) were very strong antioxidant, by DPPH assay. Phenolic and carotenoid compounds in rice bran extracts of red rice and black rice were the major contributor in antioxidant activity by DPPH assay. Rice bran extracts of black rice had linear results by FRAP and DPPH assays. 


2011 ◽  
Vol 24 (3) ◽  
pp. 273-281 ◽  
Author(s):  
Dong-Ju Kim ◽  
Su-Noh Ryu ◽  
Sang-Jun Han ◽  
Hwa-Young Kim ◽  
Jung-Hak Kim ◽  
...  

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