scholarly journals Effects of Mulberry Leaf Tea Fermented by Monascus pilosus on Body Weight and Hepatic Antioxidant Enzyme Activities in Mouse Fed High-Fat Diet

2013 ◽  
Vol 26 (1) ◽  
pp. 66-77 ◽  
Author(s):  
Sang-Il Lee ◽  
Ye-Kyung Lee ◽  
In-Ae Lee ◽  
Jongkeun Choi ◽  
Soon-Dong Kim ◽  
...  
Keyword(s):  
Body Weight ◽  
Antioxidant Enzyme ◽  
Enzyme Activities ◽  
High Fat Diet ◽  
Antioxidant Enzyme Activities ◽  
High Fat ◽  
Mulberry Leaf ◽  
Monascus Pilosus

Effect of dietary curcumin and capsaicin on testicular and hepatic oxidant–antioxidant status in rats fed a high-fat diet

2019 ◽  
Vol 44 (7) ◽  
pp. 774-782 ◽  
Author(s):  
Sevda Tanrıkulu-Küçük ◽  
Canan Başaran-Küçükgergin ◽  
Muhammed Seyithanoğlu ◽  
Semra Doğru-Abbasoğlu ◽  
Hikmet Koçak ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protein Expression ◽  
Antioxidant Enzyme ◽  
Enzyme Activities ◽  
High Fat Diet ◽  
Antioxidant Status ◽  
Control Group ◽  
Antioxidant Enzyme Activities ◽  
Transferase Activity ◽  
High Fat

This study investigated the effects of curcumin and capsaicin on testicular and hepatic oxidant–antioxidant status in rats fed a high-fat diet (HFD). Male Sprague–Dawley rats were divided into 5 groups (8 rats per group). The control group was fed a normal control diet (standard laboratory chow), the HFD group was fed HFD (60% of total calories from fat), the HFD+CUR group received HFD supplemented with curcumin (1.5 g curcumin/kg HFD), the HFD+CAP group was given HFD supplemented with capsaicin (0.15 g capsaicin/kg HFD), and the HFD+CUR+CAP group received HFD supplemented with curcumin and capsaicin for 16 weeks. Hepatic and testicular thiobarbituric acid reactive substances (TBARS), reactive oxygen species (ROS), glutathione (GSH) levels, glutathione transferase activity, and Cu-Zn superoxide dismutase, glutathione peroxidase, and catalase protein expression and enzyme activities were measured. Protein expression was determined by Western blotting. GSH levels and antioxidant enzyme activities were measured with colorimetric methods. HFD slightly increased hepatic and testicular oxidative stress parameters. GSH levels did not change between groups. TBARS and ROS levels were significantly reduced in the HFD+CUR+CAP group compared with the HFD group. Liver and testis antioxidant enzyme activities and expression increased significantly with combined capsaicin and curcumin treatment. Curcumin and capsaicin treatment attenuated testicular and hepatic oxidative stress and enhanced the antioxidant defense system. The combination of capsaicin and curcumin with HFD seems to have some remarkable and beneficial effects on testicular oxidative damage in the fatty liver rat model.

Effect of Carnosine on Renal Function, Oxidation and Glycation Products in the Kidneys of High-Fat Diet/Streptozotocin-Induced Diabetic Rats

2017 ◽  
Vol 125 (05) ◽  
pp. 282-289 ◽  
Author(s):  
Abdurrahman Fatih Aydın ◽  
Canan Küçükgergin ◽  
İlknur Bingül ◽  
Işın Doğan-Ekici ◽  
Semra Doğru-Abbasoğlu ◽  
...  
Keyword(s):  
Renal Function ◽  
Antioxidant Enzyme ◽  
Enzyme Activities ◽  
High Fat Diet ◽  
Protein Carbonyl ◽  
Diabetic Rats ◽  
Oxidation Products ◽  
Antioxidant Enzyme Activities ◽  
High Fat ◽  
Antioxidant Power

Abstract High fat diet (HFD) and low dose of streptozotocin (STZ)-treated rats provide an animal model for type 2 Diabetes Mellitus (T2DM). Oxidative stress plays a role in the development of diabetic complications. Carnosine (CAR) has antioxidant and antiglycating properties. We investigated effects of CAR on renal function, oxidation and glycation products in HFD+STZ-rats. Rats were fed with HFD (60% of total calories from fat) for 4 weeks and then a single dose STZ (40 mg/kg; i.p.) was applied. Rats with blood glucose levels above 200 mg/dL were fed with HFD until the end of the 12th week. CAR (250 mg/kg body weight; i.p.; 5 times a week) was administered to rats for the last 4 weeks. Glycated hemoglobin (HbA1c), glucose, lipids, and andrenal function tests in serum as well as reactive oxygen species, malondialdehyde, protein carbonyl, advanced oxidation protein products, advanced glycation end products (AGEs), antioxidant power, and antioxidant enzyme activities and their mRNA expressions in kidneys were determined. CAR treatment did not alter glucose and HbA1c, but it decreased serum lipids, creatinine, and urea levels in HFD+STZ rats. Oxidation products of lipids and proteins and AGEs levels decreased, but antioxidant enzyme activities and their mRNA expressions remained unchanged due to CAR treatment. Our results indicate that CAR treatment alleviated renal function and decreased accumulation of oxidation and glycation products in kidneys in HFD+STZ-rats.

B Vitamins Can Reduce Body Weight Gain by Increasing Metabolism-related Enzyme Activities in Rats Fed on a High-Fat Diet

2018 ◽  
Vol 38 (1) ◽  
pp. 174-183 ◽  
Author(s):  
Ying Zheng ◽  
Ai-guo Ma ◽  
Ming-ci Zheng ◽  
Qiu-zhen Wang ◽  
Hui Liang ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Enzyme Activities ◽  
High Fat Diet ◽  
Body Weight Gain ◽  
B Vitamins ◽  
High Fat ◽  
Reduce Body Weight ◽  
Related Enzyme

The pecan nut (Carya illinoinensis) and its oil and polyphenolic fractions differentially modulate lipid metabolism and the antioxidant enzyme activities in rats fed high-fat diets

2015 ◽  
Vol 168 ◽  
pp. 529-537 ◽  
Author(s):  
Jesús A. Domínguez-Avila ◽  
Emilio Alvarez-Parrilla ◽  
José A. López-Díaz ◽  
Ignacio E. Maldonado-Mendoza ◽  
María del Consuelo Gómez-García ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Antioxidant Enzyme ◽  
Enzyme Activities ◽  
Carya Illinoinensis ◽  
Antioxidant Enzyme Activities ◽  
High Fat ◽  
High Fat Diets ◽  
Fat Diets

Supplementation of grape seed and skin extract to orlistat therapy prevents high-fat diet-induced murine spleen lipotoxicity

2018 ◽  
Vol 43 (8) ◽  
pp. 782-794 ◽  
Author(s):  
Takwa Bedhiafi ◽  
Kamel Charradi ◽  
Mouna Ben Azaiz ◽  
Mohamed Mahmoudi ◽  
Issam Msakni ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Body Weight ◽  
High Fat Diet ◽  
Body Weight Gain ◽  
Grape Seed ◽  
Lymphoid Organ ◽  
Antioxidant Enzyme Activities ◽  
Skin Extract ◽  
High Fat ◽  
Necrosis Factor Alpha

Spleen is the largest lymphoid organ and obesity is related to an elevated risk of immunity dysfunction. The mechanism whereby fat adversely affects the spleen is poorly understood. This study was designed to assess the effectiveness of grape seed and skin extract (GSSE) and orlistat (Xenical, Xe) on high-fat diet (HFD)-induced spleen lipotoxicity. Obese rats were treated either with GSSE (4 g/kg body weight) or Xe (2 mg/kg body weight) or GSSE+Xe and monitored for weight loss for 3 months. Animals were then sacrificed and their spleen used for the evaluation of lipotoxicity-induced oxidative stress and inflammation as well as the putative protection afforded by GSSE and Xe treatment. HFD induced body weight gain and glycogen accumulation into the spleen; ectopic deposition of cholesterol and triglycerides and an oxidative stress characterized by increased lipoperoxidation and carbonylation; inhibition of antioxidant enzyme activities, such as catalase, glutathione peroxidase, and superoxide dismutase; depletion of zinc and copper; and a concomitant increase in calcium. HFD also increased plasma pro-inflammatory cytokines, such as interleukin (IL)-6, IL-17A, tumour necrosis factor alpha, and C-reactive protein, and decreased plasma IL-10 and adiponectin. Importantly, GSSE counteracted all the deleterious effects of HFD on spleen (i.e., lipotoxicity, oxidative stress, and inflammation) and the best protection was obtained when combining Xe+GSSE. Combining GSSE with Xe prevented against fat-induced spleen lipotoxicity, oxidative stress, and inflammation; this combination may be beneficial in other diseases related to the spleen.

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