Na3VO4 as a new anode material for lithium-ion batteries

Sodium vanadate, Na3VO4 is firstly prepared as new anode materials for lithium-ion batteries (LIBs), showing satisfactory capacity, ultra-long cycle life and excellent rate capability. When cycling at the current of...

Aqueous zinc ion batteries based sodium vanadate electrode materials with long lifespan and high energy density

With the excessive consumption of non-renewable energy sources and subsequent environmental pollution, one converts their research focuses to develop some emerging energy storage devices with desired performances. Aqueous zinc-ion batteries...

Impact of Sodium Vanadium Oxide (NaV3O8, NVO) Material Synthesis Conditions on Charge Storage Mechanism in Zn-ion Aqueous Batteries

The electrochemical charge storage of sodium vanadate (NaV3O8 or NVO) cathodes in aqueous Zn-ion batteries has been hypothesized to be influenced by the inclusion of structural water for facilitating ion...

High T3 Induces β-Cell Insulin Resistance via Endoplasmic Reticulum Stress

Hyperthyroidism can cause glucose metabolism disorders and insulin resistance. Insulin resistance in muscle and adipose tissues has been extensively studied, whereas investigations on β-cell insulin resistance are limited. This study preliminarily explored the effects of high T3 levels on β-cell line (MIN6) insulin resistance, as well as the roles of endoplasmic reticulum stress (ERS). In this study, we treated β-cell line with T3, with or without an inhibitor of phosphotyrosine phosphatases (PTPs, sodium vanadate) or ERS inhibitor (4-PBA). The results indicated that high levels of T3 significantly inhibited insulin secretion in β-cell line. In addition, we observed an upregulation of p-IRS-1ser307 and downregulation of Akt. These results can be corrected by sodium vanadate. Moreover, high T3 levels upregulate the ERS-related proteins PERK, IRE1, ATF6, and GRP78, as well as ERS-related apoptosis CHOP and caspase-12. Similarly, this change can be corrected by 4-PBA. These results suggest that high T3 levels can induce insulin resistance in β-cell line by activating ERS and the apoptotic pathway.