Enhancing Resonance Imaging Sensitivity and Upconversion Emission of Gd-based Nanoscale Coordination Polymers by Combination With Au Nanoparticles

Nanoscale coordination polymers (NCPs) are attracting increasing research interest due to their highly tailorable structure, feasible functionality and promising application in various fields, especially in biomedical applications, they are excellent contrast agents for bioimaging, biosensing and clinical diagnosis. Currently, to overcome the low relaxation rate and unitary information of magnetic resonance imaging, the design of multifunction contrast agent is critical and challenging. Herein, a new Au nanoparticles/Gd-based coordination polymer (Au@GdCP) composite nanoparticles have been fabricated by a facile hydrothermal methodology. The Au@GdCP exhibit excellent magnetic resonance, bright upconversion luminescence (UC) and good biocompatibility. More importantly, with the introduction of Au nanoparticles, the magnetization and longitudinal relaxation rate (r1) of the nanocomposite is enhanced significantly, with 131.6-fold from 5.19 emu/g to 683.52 emu/g and 11.5 fold from 0.248 mM–1S–1 to 2.853 mM–1S–1 enhancement, respectively, as well as better UC property over GdCPs. This work may offer a new way to develop multifunctional NCPs with enhanced performance in image-guided diagnosis and therapy.

Nanoscale coordination polymers induce immunogenic cell death by amplifying radiation therapy mediated oxidative stress

Radiation therapy can potentially induce immunogenic cell death, thereby priming anti-tumor adaptive immune responses. However, radiation-induced systemic immune responses are very rare and insufficient to meet clinical needs. Here, we demonstrate a synergetic strategy for boosting radiation-induced immunogenic cell death by constructing gadolinium-hemin based nanoscale coordination polymers to simultaneously perform X-ray deposition and glutathione depletion. Subsequently, immunogenic cell death is induced by sensitized radiation to potentiate checkpoint blockade immunotherapies against primary and metastatic tumors. In conclusion, nanoscale coordination polymers-sensitized radiation therapy exhibits biocompatibility and therapeutic efficacy in preclinical cancer models, and has the potential for further application in cancer radio-immunotherapy.

Biodegradable copper–metformin nanoscale coordination polymers for enhanced chemo/chemodynamic synergistic therapy by reducing oxygen consumption to promote H2O2 accumulation

A new therapeutic nanoplatform based on Dox@Cu–Met NPs was constructed, which could reduce the consumption of O2 and elevate H2O2 content for effective chemo/chemodynamic synergistic therapy.

Green facile synthesis to develop nanoscale coordination polymers as lysosome-targetable luminescent bioprobes

A facile green hand grinding technique has been adopted towards the design of three nanoscale crystalline materials that serves as an excellent selective bio tracker for intracellular lysosome.