scholarly journals Enhancing Resonance Imaging Sensitivity and Upconversion Emission of Gd-based Nanoscale Coordination Polymers by Combination With Au Nanoparticles

2021 ◽  
Author(s):  
Chen Xiao ◽  
Tuck Yun Change ◽  
Yin Li ◽  
Hualan Xu ◽  
Shengliang Zhong
Keyword(s):  
Magnetic Resonance ◽  
Relaxation Rate ◽  
Coordination Polymers ◽  
Au Nanoparticles ◽  
Upconversion Luminescence ◽  
Upconversion Emission ◽  
Resonance Imaging ◽  
Promising Application ◽  
Good Biocompatibility ◽  
Nanoscale Coordination Polymers

Abstract Nanoscale coordination polymers (NCPs) are attracting increasing research interest due to their highly tailorable structure, feasible functionality and promising application in various fields, especially in biomedical applications, they are excellent contrast agents for bioimaging, biosensing and clinical diagnosis. Currently, to overcome the low relaxation rate and unitary information of magnetic resonance imaging, the design of multifunction contrast agent is critical and challenging. Herein, a new Au nanoparticles/Gd-based coordination polymer (Au@GdCP) composite nanoparticles have been fabricated by a facile hydrothermal methodology. The Au@GdCP exhibit excellent magnetic resonance, bright upconversion luminescence (UC) and good biocompatibility. More importantly, with the introduction of Au nanoparticles, the magnetization and longitudinal relaxation rate (r1) of the nanocomposite is enhanced significantly, with 131.6-fold from 5.19 emu/g to 683.52 emu/g and 11.5 fold from 0.248 mM–1S–1 to 2.853 mM–1S–1 enhancement, respectively, as well as better UC property over GdCPs. This work may offer a new way to develop multifunctional NCPs with enhanced performance in image-guided diagnosis and therapy.

Theranostic nanoscale coordination polymers for magnetic resonance imaging and bisphosphonate delivery

2014 ◽  
Vol 2 (46) ◽  
pp. 8249-8255 ◽  
Author(s):  
Demin Liu ◽  
Chunbai He ◽  
Christopher Poon ◽  
Wenbin Lin
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Cancer Therapy ◽  
Coordination Polymers ◽  
Resonance Imaging ◽  
Weighted Magnetic Resonance Imaging ◽  
Nanoscale Coordination Polymers

Mn-zoledronate NCP carries 63 wt% of zoledronate for cancer therapy and 13 wt% of Mn2+ for T1-weighted magnetic resonance imaging.

Multi-functional NaErF4:Yb nanorods: enhanced red upconversion emission, in vitro cell, in vivo X-ray, and T2-weighted magnetic resonance imaging

Nanoscale ◽  
2014 ◽  
Vol 6 (5) ◽  
pp. 2855-2860 ◽  
Author(s):  
Haibo Wang ◽  
Wei Lu ◽  
Tianmei Zeng ◽  
Zhigao Yi ◽  
Ling Rao ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Upconversion Emission ◽  
Resonance Imaging ◽  
X Ray ◽  
Weighted Magnetic Resonance Imaging ◽  
New Type ◽  
First Time

A new type of multi-functional NaErF4 nanoprobe with enhanced red upconversion emission was developed and used for in vitro cell, in vivo X-ray and T2-weighted magnetic resonance imaging for the first time.

Stimuli-responsive biodegradable and gadolinium-based poly[N-(2-hydroxypropyl) methacrylamide] copolymers: their potential as targeting and safe magnetic resonance imaging probes

2017 ◽  
Vol 5 (15) ◽  
pp. 2763-2774 ◽  
Author(s):  
Xue Li ◽  
Ling Sun ◽  
Xiaoli Wei ◽  
Qiang Luo ◽  
Hao Cai ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Signal Intensity ◽  
Stimuli Responsive ◽  
Resonance Imaging ◽  
Hydroxypropyl Methacrylamide ◽  
Imaging Probes ◽  
Good Biocompatibility

Functionalized and biodegradable block pHPMA copolymer–gadolinium conjugates demonstrated good biocompatibility, high T1 relaxivity, and enhanced tumor signal intensity for MRI.

scholarly journals Multifunctional mixed-metal nanoscale coordination polymers for triple-modality imaging-guided photodynamic therapy

2017 ◽  
Vol 8 (5) ◽  
pp. 3891-3897 ◽  
Author(s):  
Yong-Mei Wang ◽  
Wei Liu ◽  
Xue-Bo Yin
Keyword(s):  
Computed Tomography ◽  
Photodynamic Therapy ◽  
Magnetic Resonance ◽  
Coordination Polymers ◽  
X Ray ◽  
Mixed Metal ◽  
Ru Complex ◽  
X Ray Computed ◽  
Nanoscale Coordination Polymers

Multifunctional mixed-metal nanoscale coordination polymers (NCPs) are robustly prepared with a Ru complex, Gd3+, and Yb3+. The NCPs were used as fluorescence, magnetic resonance, and X-ray computed tomography triple-modality imaging and imaging-guided photodynamic therapy.

scholarly journals Colloidally Stable P(DMA-AGME)-Ale-Coated Gd(Tb)F3:Tb3+(Gd3+),Yb3+,Nd3+ Nanoparticles as a Multimodal Contrast Agent for Down- and Upconversion Luminescence, Magnetic Resonance Imaging, and Computed Tomography

Nanomaterials ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 230
Author(s):  
Oleksandr Shapoval ◽  
Viktoriia Oleksa ◽  
Miroslav Šlouf ◽  
Volodymyr Lobaz ◽  
Olga Trhlíková ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Upconversion Luminescence ◽  
In Vitro Toxicity ◽  
Resonance Imaging ◽  
Medical Disorders ◽  
Wide Range ◽  
T1 And T2

Multimodal imaging, integrating several modalities including down- and up-conversion luminescence, T1- and T2(T2*)-weighted MRI, and CT contrasting in one system, is very promising for improved diagnosis of severe medical disorders. To reach the goal, it is necessary to develop suitable nanoparticles that are highly colloidally stable in biologically relevant media. Here, hydrophilic poly(N,N-dimethylacrylamide-N-acryloylglycine methyl ester)-alendronate-[P(DMA-AGME)-Ale]-coated Gd(Tb)F3:Tb3+(Gd3+),Yb3+,Nd3+ nanoparticles were synthesized by a coprecipitation method in ethylene glycol (EG) followed by coating with the polymer. The particles were tho-roughly characterized by a dynamic light scattering (DLS), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), X-ray energy dispersive spectroscopy (EDAX), selected area electron diffraction (SAED), elemental ana-lysis and fluorescence spectroscopy. Aqueous particle dispersions exhibited excellent colloidal stability in water and physiological buffers. In vitro toxicity assessments suggested no or only mild toxicity of the surface-engineered Gd(Tb)F3:Tb3+(Gd3+),Yb3+,Nd3+ particles in a wide range of concentrations. Internalization of the particles by several types of cells, including HeLa, HF, HepG2, and INS, was confirmed by a down- and up-conversion confocal microscopy. Newly developed particles thus proved to be an efficient contrast agent for fluorescence imaging, T1- and T2(T2*)-weighted magnetic resonance imaging (MRI), and computed tomography (CT).

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