Engineering the Composition of Microfibers to Enhance the Remodeling of a Cell-Free Vascular Graft

The remodeling of vascular grafts is critical for blood vessel regeneration. However, most scaffold materials have limited cell infiltration. In this study, we designed and fabricated a scaffold that incorporates a fast-degrading polymer polydioxanone (PDO) into the microfibrous structure by means of electrospinning technology. Blending PDO with base polymer decreases the density of electrospun microfibers yet did not compromise the mechanical and structural properties of the scaffold, and effectively enhanced cell infiltration. We then used this technique to fabricate a tubular scaffold with heparin conjugated to the surface to suppress thrombosis, and the construct was implanted into the carotid artery as a vascular graft in animal studies. This graft significantly promoted cell infiltration, and the biochemical cues such as immobilized stromal cell-derived factor-1α further enhanced cell recruitment and the long-term patency of the grafts. This work provides an approach to optimize the microfeatures of vascular grafts, and will have broad applications in scaffold design and fabrication for regenerative engineering.

An Internet of Things Governance Architecture with Applications in Healthcare

The astonishing expansion of Internet of Things has opened a lot of opportunities for related domains to employ strategies that were successfully used for the “things” governance. Furthermore, because of the technology blending in the most common household devices and wearable items, it becomes very easy for the computers to sense the surrounding environment and to collect information about the inhabitants, therefore transforming the intelligent house in a Home Care System (HCS). For medical conditions like dementia and its associated diseases, it is very convenient to monitor the patients in their living space because the patient will benefit from their home comfort. In addition, the costs for in hospital monitoring will decrease. This chapter proposes an Internet of Things Governance Architecture that can be used to sustain and monitor a complex e-health system, with application especially for patients with dementia and its associated diseases.

An Internet of Things Governance Architecture with Applications in Healthcare

The astonishing expansion of Internet of Things has opened a lot of opportunities for related domains to employ strategies that were successfully used for the “things” governance. Furthermore, because of the technology blending in the most common household devices and wearable items, it becomes very easy for the computers to sense the surrounding environment and to collect information about the inhabitants, therefore transforming the intelligent house in a Home Care System (HCS). For medical conditions like dementia and its associated diseases, it is very convenient to monitor the patients in their living space because the patient will benefit from their home comfort. In addition, the costs for in hospital monitoring will decrease. This chapter proposes an Internet of Things Governance Architecture that can be used to sustain and monitor a complex e-health system, with application especially for patients with dementia and its associated diseases.

Application of Information Technology in Engineering Thermodynamics

Information technology has been greatly developed in recent years and brings opportunities as well as challenges for engineering courses. This paper surveys the development and characteristics of information technology. Then different methods of information technology are analyzed and applied. The new teaching mode based on information technology – blending teaching as well as detailed teaching case is proposed in the course of Engineering Thermodynamics.