Advanced Large-Scale Nanofabrication Route for Ultrasensitive SERS Platforms Based on Precisely Shaped Gold Nanostructures

One of the key issues for SERS-based trace applications is engineering structurally uniform substrates with ultrasensitivity, stability, and good reproducibility. A label-free, cost-effective, and reproducible fabrication strategy of ultrasensitive SERS sensors was reported in this work. Herein, we present recent progress in self-assembly-based synthesis to elaborate precisely shaped and abundant gold nanoparticles in a large area. We demonstrated that shape control is driven by the selective adsorption of a cation (Na+, K+, and H+) on a single facet of gold nanocrystal seeds during the growth process. We studied SERS features as a function of morphology. Importantly, we found a correlation between the shape and experimental SERS enhancement factors. We observed a detection threshold of 10−20 M of bipyridine ethylene (BPE), which matches the lowest value determined in literature for BPE until now. Such novel sensing finding could be very promising for diseases and pathogen detection and opens up an avenue toward predicting which other morphologies could offer improved sensitivity.

Simple Determination of Gold Nanocrystal Dimensions by Analytical Ultracentrifugation via Surface Ligand-Solvent Density Matching

Analytical ultracentrifugation (AUC) is a powerful technique to observe colloidal nanocrystals (NCs) directly in solution and obtain critical information about their physical-chemical properties. Nevertheless, a more comprehensive implementation of AUC for the characterisation of such a class of crystalline colloids has been traditionally impaired by the requirement of having a priori knowledge of the complex, multilayered structure formed by NC in solution. This includes the nature (density and mass) of the surface ligands (SLs) that provide NC colloidal stability and the shell of solvent molecules formed on it. Herein, we propose a methodology to determine the NCs size by using SLs with a density equal to that of the solvent. Thereby, the buoyancy force of the SL shell is neutral, and the density of the NCs is sufficient a priori knowledge to calculate their related mass and size distributions. The simplicity and reliability of the method are evaluated with cetyltrimethylammonium bromide (CTAB) stabilized spherical gold NCs (AuNCs) of dimensions ranging from 1 to 17 nm. The proposed method has great potential to be transferred to any non-crystalline and crystalline colloids of different nature and composition, which have a density that is equal to the bulk and can be stabilized by SLs having a density that matches that of the solvent.

Revolution in the Synthesis, Physio-chemical and Biological Characterization of Gold Nanoplatform

: This review article mainly focuses on the revolution on the synthesis of gold nanoplatform from previous era to the present era. Initially, the gold nanoplatform was widely used by the electrical and electronic industries in their products due to their remarkable properties such as large surface volume, redox activity, fluorescence quenching and optical electronic properties. In this era, due to the invention of localised surface plasmonic resonance, optoacoustic, photothermal and theragnostic characteristics of the gold nanoplatform and their application in biosensor and various diagnostic methods, the pharmaceutical and biotechnological companies started showing their interest in manufacturing of gold nanoplatform and used in their new product development. This colloidal dispersion is synthesized in various forms such as, gold nanoparticle, gold nanoplatform, plasmonic gold nanoparticle, amphiphilic gold nanoparticle and gold nanocrystal. This review article describes various methods of preparation of gold nanoplatform with different size, shape and physiobiological properties and their applications in different fields.