The use of biomass of Streptomycetes as a stimulator of some body indices of chickens

Introduction. Currently, various biologically active substances, preferably of biological and not synthetic origin, with having a growth stimulating effect, are frequently used as food additives in the poultry industry. Some of these substances with a stimulating effect on the growth of chickens are represented by the biomass obtained from apathogenic strains of Streptomycetes. Material and methods. The investigations were conduvted within the ILR “Avicola Sărătenii-Vech” v. Sărătenii Vechi, Telenești district. The biological material was one-day-old Adler's silver chickens. The research was carried out on 150 chickens (one control and two experimental), which were randomly distributed in three groups of 50 chickens in each. Results. The dynamics of body weight was higher in the experimental group of chickens which, received biomass of Streptomycetes, indicating that the chickens in experimental group II recorded a 5.1% increase in body weight compared to chickens from the control group. The analysis of blood indices showed a slight increase of the number of lymphocytes and eosinophils, from 4 to 9% in experimental group II. Conclusions. The use of biomass of Streptomycetes in feeding the experimental grup of chickens demonstrated an increase of body weight with 5.1% compared to the chickens from the control group. The biomass of Streptomycetes stimulated an increase of the number of limbocytes and eosinophils in chickens from the experimental group II, thus demonstrating an immunostimulatory effect.

Successful rechallenge with cetuximab after progression with nivolumab for recurrent cervical lymph node metastasis from carcinoma of the tongue

We demonstrate the effectiveness of readministering cetuximab as a salvage chemotherapeutic agent after nivolumab administration to a patient with a recurrence of cervical lymph node metastasis after tongue cancer surgery. We can infer that the immunostimulatory effect of nivolumab and reactivation of cetuximab enhance the antitumor effect of the therapy.

Replacement of oxygen with sulfur on the furanose ring of cyclic dinucleotides enhances the immunostimulatory effect via STING activation

Cyclic dinucleotide analogues that have sulfur atoms on the furanose rings act as potent and stable STING agonists.