Differential dopamine release by psychosis-generating and non-psychosis-generating addictive substances in the nucleus accumbens and dorsomedial striatum

Schizophrenia is associated with three main categories of symptoms; positive, negative and cognitive. Of these, only the positive symptoms respond well to treatment with antipsychotics. Due to the lack of effect of antipsychotics on negative symptoms, it has been suggested that while the positive symptoms are related to a hyperdopaminergic state in associative striatum, the negative symptoms may be a result of a reduced dopamine (DA) activity in the nucleus accumbens (nAc). Drug abuse is common in schizophrenia, supposedly alleviating negative symptomatology. Some, but not all, drugs aggravate psychosis, tentatively due to differential effects on DA activity in striatal regions. Here this hypothesis was tested in rats by using a double-probe microdialysis technique to simultaneously assess DA release in the nAc and associative striatum (dorsomedial striatum; DMS) following administration of the psychosis-generating substances amphetamine (0.5 mg/kg), cocaine (15 mg/kg) and Δ9-tetrahydrocannabinol (THC, 3 mg/kg), and the generally non-psychosis-generating substances ethanol (2.5 g/kg), nicotine (0.36 mg/kg) and morphine (5 mg/kg). The data show that amphetamine and cocaine produce identical DA elevations both in the nAc and DMS, whereas nicotine increases DA in nAc only. Ethanol and morphine both increased DMS DA, but weaker and in a qualitatively different way than in nAc, suggesting that the manner in which DA is increased might be important to the triggering of psychosis. THC elevated DA in neither region, indicating that the pro-psychotic effects of THC are not related to DA release. We conclude that psychosis-generating substances affect striatal DA release differently than non-psychosis-generating substances.

The spacecraft wake as a tool to detect cold ions: Turning a problem into a feature

<p>Wakes behind scientific spacecraft caused by supersonic drifting ions is common in collisionless plasmas. Such wakes change the local plasma conditions and disturb in situ observations of the geophysical plasma parameters. We concentrate on observations of the electric field with double-probe instruments. Sometimes the wake effects are caused by the spacecraft body, are minor and easy to detect, and can be compensated for in a reasonable way. We show an example from the Cluster spacecraft in the solar wind. Sometimes the effects are caused by an electrostatic structure around a positively charged spacecraft causing an enhanced wake and major effects on the local plasma. Here observations of the geophysical electric field with the double-probe technique becomes impossible. Rather, the wake can be used to detect the presence of cold positive ions. Together with other instruments, also the cold ion flux can be estimated. We discuss such examples from the Cluster spacecraft in the magnetospheric lobes. For an intermediate range of parameters, when the drift energy of the ions is comparable to the equivalent charge of the spacecraft, also the charged wire booms of a double-probe instrument must be taken into account to extract useful information from the observations. We show an example from the MMS spacecraft near the magnetopause. With understanding of the physics causing wakes behind spacecraft, the local effects can sometimes be compensated for. When this is not possible, sometimes entirely new geophysical parameters can be estimated. An example is the flux of cold positive ions, constituting a major part of the mass outflow from planet Earth, using electric and magnetic field instruments on a spacecraft charged due to photoionization</p><p> </p>

Double-Probe Ultrasonic Detection Method for Cracks in Steel Structure

To investigate the feasibility analysis of ultrasonic detection methods applied in the fatigue crack characteristics of steel structures, the double-probe ultrasonic detection method was applied to the prefabricated crack specimens fabricated from of flat steel plate. The test features including length, width, depth, angle, and crack location were considered. Based on the calculation of geometric relationship and experimental results, a method for judging the crack tip position was developed. The formulae for determining the depth and angle of crack were not only established but also analyzed the detection accuracy of the double-probe penetration method. The feasibility of this method in weld crack detection was verified by a combination of the finite-element simulation and actual experiment. The results showed that the ratio of crack tip wave height to crack free wave height ωK is related to the K value (K value is one of the parameters of the angle probe, which is defined as the tangent value of angle β between the incident wave and an interface normal line), but the influence of crack depth and width can be ignored. Due to higher detection accuracy for crack depth and angle, a double-probe penetrating method could improve the detection accuracy for crack angle by nearly 5% more than the single probe pulse reflection method. Therefore, application of the double-probe penetrating method had a significant impact on accurate crack detection of rib-to-deck weld in the practical issue.