Calibration Of The Short Irradiation Facility For k0 - NAA Implementation At The IEA-R1 Reactor

The short irradiation facility of the IEA-R1 nuclear research reactor at IPEN, São Paulo, Brazil, has been used for short irradiation of samples for the purpose of determining the concentration of elements of these samples through the use of the instrumental neutron activation analysis technique. With the aim of implementing the k0-NAA method at the Neutron Activation Analysis Laboratory (LAN), the reactor parameters a and f were obtained using the bare triple method. In this method, a set of three neutron flux monitors were irradiated without Cd-cover. The efficiency curve of the gamma-ray spectrometer used was determined by measuring calibrated radioactive sources at the commonly used counting geometries. The results for the parameters a and f were respectively 0.0384±0.0016 and 35.67±0.26. This value of f shows that the neutrons in the irradiation position are well thermalized.The variation of these parameters was studied with time and the reproducibility was verified.

Highly Effective Inactivation of SARS-CoV-2 by Conjugated Polymers and Oligomers

ABSTRACTThe current Covid-19 Pandemic caused by the highly contagious SARS-CoV-2 virus has proven extremely difficult to prevent or control. Currently there are few treatment options and very few long-lasting disinfectants available to prevent the spread. While masks and protective clothing and “social distancing” may offer some protection, their use has not always halted or slowed the spread. Several vaccines are currently undergoing testing; however there is still a critical need to provide new methods for inactivating the virus before it can spread and infect humans. In the present study we examined the inactivation of SARS-CoV-2 by synthetic conjugated polymers and oligomers developed in our laboratories as antimicrobials for bacteria, fungi and non-enveloped viruses. Our results show that we can obtain highly effective light induced inactivation with several of these oligomers and polymers including irradiation with near-UV and visible light. With both the oligomers and polymers, we can reach several logs of inactivation with relatively short irradiation times. Our results suggest several applications involving the incorporation of these materials in wipes, sprays, masks and clothing and other Personal Protection Equipment (PPE) that can be useful in preventing infections and the spreading of this deadly virus and future outbreaks from similar viruses.

A Caged E3 Ligase Ligand for PROTAC-Mediated Protein Degradation with Light

A caging group has been appended to a widely used Von Hippel Lindau (VHL) E3 ligase ligand for targeted protein degradation with PROTACs. Proteolysis is triggered only after a short irradiation time allowing spatiotemporal control of the protein’s fate.

A Caged E3 Ligase Ligand for PROTAC-Mediated Protein Degradation with Light

A caging group has been appended to a widely used Von Hippel Lindau (VHL) E3 ligase ligand for targeted protein degradation with PROTACs. Proteolysis is triggered only after a short irradiation time allowing spatiotemporal control of the protein’s fate.

A Caged E3 Ligase Ligand for PROTAC-Mediated Protein Degradation with Light

A caging group has been appended to a widely used Von Hippel Lindau (VHL) E3 ligase ligand for targeted protein degradation with PROTACs. Proteolysis is triggered only after a short irradiation time allowing spatiotemporal control of the protein’s fate.