This chapter focuses on past emerging viruses. For our ancestors, it was their change in lifestyle from hunter-gatherer to farmer some 10,000 years ago that triggered an onslaught of new, emerging infectious diseases. The switch from the nomadic life to living in fixed communities, along with the change from hunting animals to their domestication, encouraged spillover of new viruses as well as other types of microbes. As such, the early farmers’ emerging viruses jumped from the animals they domesticated, while the cramped conditions of life in villages, and later towns, gave these viruses the opportunity to thrive in their new human host. This was the beginning of many of our acute childhood infections, so-called crowd diseases. The chapter looks at how these ancient afflictions have evolved over the intervening 10,000 years with a view to understanding how diseases like COVID-19 might evolve over time. It considers smallpox and measles, which are both highly infectious, lethal, airborne viruses, as well as polio, which is spread by faecal–oral contamination.