scholarly journals A path less travelled — Short review on ossifying fibroma and osseous dysplasia

2021 ◽  
Vol 11 (2) ◽  
pp. 90-95
Author(s):  
Deepali P Mohite ◽  
Devendra H Palve ◽  
Snehal R Udapure ◽  
Vinanti V Bodele ◽  
Mrunali D Jambhulkar ◽  
...  
Keyword(s):  
Fibrous Tissue ◽  
Short Review ◽  
World Health ◽  
Ossifying Fibroma ◽  
Osseous Lesion ◽  
Osseous Dysplasia ◽  
Cementifying Fibroma ◽  
Calcified Tissue ◽  
Health Organization ◽  
Slow Growing

Fibro-osseous lesions (FOL) are characterized by replacement of normal bone by fibrous tissue containing a newly formed mineralized product. The mineralized product may be ossification (sometimes cementum formation) or calcification of fibrous tissue by metaplasia. These lesions have similar radiographic and histopathologic features hence the term fibre- osseous lesion is not a diagnosis, rather a description of the presence of fibrous and calcified tissue. They may be developmental (fibrous dysplasia), reactive (cemento-osseous dysplasia) or neoplastic (ossifying/cementifying fibroma). This article presents the commonly used classification for fibro-osseous lesions and an insight into a few changes that have been introduced in the recent past with emphasis on Ossifying Fibroma and Osseous Dysplasia.Ossifying fibromas are considered as benign fibro-osseous neoplasms which are principally encountered within the jawbones. Cemento-osseous dysplasias are non-neoplastic fibro- osseous lesion. Since 1971, the World Health Organization classified cemental lesions into 4 distinct entities, as follows: Periapical Cemental Dysplasia, Benign Cementoblastoma (true cementoma), Cementifying Fibroma and Gigantiform Cementoma (GC). The term, gigantiform cementoma, may imply a solitary process but it is misleading because the condition typically presents as slow-growing, multifocal/multiquadrant and expansile lesions involving both jaws. WHO classified it in Osseous dysplasia and El-Mofty et al. under Ossifying fibroma.

scholarly journals Massive Juvenile Ossifying Fibroma of the Frontal Bone

2014 ◽  
Vol 7 (1) ◽  
pp. 36-39
Author(s):  
SS Bist ◽  
Sarita Mishra ◽  
Vinish Agrawal ◽  
Bhartandu Bharti ◽  
Himanshual Kala
Keyword(s):  
Lateral Displacement ◽  
Fibrous Tissue ◽  
Frontal Bone ◽  
Ossifying Fibroma ◽  
Lamellar Bone ◽  
Craniofacial Skeleton ◽  
Younger Patients ◽  
Osseous Lesion ◽  
Juvenile Ossifying Fibroma ◽  
Slow Growing

ABSTRACT Ossifying fibroma is a rare, benign fibro-osseous lesion composed of lamellar bone and fibrous tissue. It occurs as an osseous lesion in the craniofacial skeleton. Clinically, lesions are usually asymptomatic, slow-growing and well-circumscribed. However, in very few cases, particularly in younger patients these tumors have demonstrated an aggressive course of development. Surgical management via a wide local excision is a necessity since it is notorious for recurrence, especially paranasal sinuses lesions. Here, we describe a case of a 9-year- old male child who had left forehead swelling with painless, progressive proptosis and downward lateral displacement of the globe for approximately 8 months. Computed tomography showed a massive expansile lesion involving the left frontal bone. The mass was excised surgically via a Lynch Howarth approach and proved histopathologically to be a juvenile ossifying fibroma. The radiological interpretation will be discussed which is helpful for diagnosis and selecting appropriate surgical approach in growing child. How to cite this article Bist SS, Mishra S, Bharti B, Agrawal V, Kala H. Massive Juvenile Ossifying Fibroma of the Frontal Bone. Clin Rhinol An Int J 2014;7(1):36-39.

A short review on important drugs under clinical trial against Covid-19

2020 ◽  
Vol 21 ◽  
Author(s):  
Namita Misra
Keyword(s):  
Respiratory Illness ◽  
Short Review ◽  
World Health ◽  
Upper Respiratory Tract ◽  
Suspected Infection ◽  
Medicinal Treatment ◽  
Travel Restrictions ◽  
Personal Level ◽  
Health Organization ◽  
Tract Infections

: Corona virus spreads from one to other person, either by touching the hands or by touching the surface contaminated with this virus, and then touching the nose or mouth. Covid-19 infected human symptoms are like any pneumonia symptoms, dry cough and high fever. Upper respiratory tract infections symptoms and sore throat are rare. First notified in china dated 12th December 2019 as a respiratory illness. In addition to travel restrictions and quarantine measures everyone should follow the World Health Organization advice guidelines on the management of humans infected with known or suspected infection with SARS-CoV-2 virus at the personal level. The development of vaccine or medicines for the same are under progress and this short review will summarize the most potential candidates such as Remdesivir, Lopinavir and Ritonavir, Chloroquine, Hydroxychloroquine, Hydroxychloroquine with Azithromycin, Favipiravir, Umifenovir, and Ribavirin for its medicinal treatment.

Central ossifying fibroma of mandible

2020 ◽  
Vol 13 (12) ◽  
pp. e239286
Author(s):  
Kumar Nilesh ◽  
Prashant Punde ◽  
Nitin Shivajirao Patil ◽  
Amol Gautam
Keyword(s):  
Fibrous Tissue ◽  
Three Dimensional ◽  
Facial Asymmetry ◽  
Ossifying Fibroma ◽  
Mandible Reconstruction ◽  
Three Dimensional Printing ◽  
Osseous Lesion ◽  
Large Size ◽  
Dimensional Printing

Ossifying fibroma (OF) is a rare, benign, fibro-osseous lesion of the jawbone characterised by replacement of the normal bone with fibrous tissue. The fibrous tissue shows varying amount of calcified structures resembling bone and/or cementum. The central variant of OF is rare, and shows predilection for mandible among the jawbone. Although it is classified as fibro-osseous lesion, it clinically behaves as a benign tumour and can grow to large size, causing bony swelling and facial asymmetry. This paper reports a case of large central OF of mandible in a 40-year-old male patient. The lesion was treated by segmental resection of mandible. Reconstruction of the surgical defect was done using avascular fibula bone graft. Role of three-dimensional printing of jaw and its benefits in surgical planning and reconstruction are also highlighted.

Nonkeratinizing Nasopharyngeal Carcinoma, Undifferentiated Type With Trisomy 2: A Case Report and Short Review of Cytogenetic and Molecular Literature

2020 ◽  
Vol 23 (6) ◽  
pp. 448-452
Author(s):  
Francesco Pontoriero ◽  
Ayaka M Silverman ◽  
Judy M Pascasio ◽  
Renu Bajaj
Keyword(s):  
Case Report ◽  
Nasopharyngeal Carcinoma ◽  
Xenograft Model ◽  
Short Review ◽  
Undifferentiated Carcinoma ◽  
World Health ◽  
Surface Epithelium ◽  
Barr Virus ◽  
Cytogenetic Aberration ◽  
Health Organization

Carcinoma originating from the surface epithelium of the nasopharynx is classified by the World Health Organization (WHO) as nasopharyngeal carcinoma (NPC) and has 3 main types: keratinizing squamous cell carcinoma (WHO type 1) and nonkeratinizing carcinoma, differentiated (WHO type II), and undifferentiated (WHO type III). Nonkeratinizing NPC is strongly associated with prior Epstein–Barr virus (EBV) infection. These tumors may be divided into differentiated and undifferentiated carcinoma. Histologically, the tumor is characterized by syncytia of large malignant cells with vesicular nuclei, conspicuous nucleoli, and easily observed mitotic figures. We report a case of a 14-year-old boy diagnosed with EBV and human papillomavirus (HPV)-positive NPC (WHO type 3) with cytogenetics showing the presence of mosaic trisomy 2. This case report brings to light a rare cytogenetic aberration to our knowledge only reported once before in the literature in a xenograft model.

scholarly journals An Overview of SARS-CoV-2 and Animal Infection

2020 ◽  
Vol 7 ◽  
Author(s):  
Mohamed A. A. Mahdy ◽  
Waleed Younis ◽  
Zamzam Ewaida
Keyword(s):  
Intermediate Host ◽  
Animal Species ◽  
Experimental Studies ◽  
Short Review ◽  
World Health ◽  
Wholesale Market ◽  
Animal Infection ◽  
Rapid Spread ◽  
Novel Coronavirus ◽  
Health Organization

A novel coronavirus has been reported as the causative pathogen of the Coronavirus disease 2019 (COVID-19) outbreak in Wuhan city, China in December 2019. Due to the rapid spread of the virus worldwide, it has been announced as a pandemic by the World Health Organization (WHO). Hospitalized patients in Wuhan were associated with the Huanan seafood wholesale market where live animals, such as poultry, bats, snakes, frogs, rabbits, marmots, and hedgehogs are sold in that market which suggests a possible zoonotic infection. It was suggested that bat is the natural host of SARS-CoV-2, but the intermediate host is still unclear. It is essential to identify the potential intermediate host to interrupt the transmission chain of the virus. Pangolin is a highly suspected candidate as an intermediate host for SARS-CoV-2. Recently, SARS-CoV-2 infection has been reported in cats, dogs, tigers, and lions. More recently SARS-CoV-2 infection affected minks severely and zoonotic transfer with a variant SARS-CoV-2 strain evidenced in Denmark, Netherlands, USA, and Spain suggesting animal-to-human and animal-to-animal transmission within mink farms. Furthermore, experimental studies documented the susceptibility of different animal species to SARS-CoV-2, such as mice, golden hamsters, cats, ferrets, non-human primates, and treeshrews. It is also essential to know the possibility of infection for other animal species. This short review aims to provide an overview on the relation between severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and animals.

Meningiomas

2018 ◽  
Author(s):  
K. E. Hovinga ◽  
Y. Esquenazi ◽  
P. H. Gutin
Keyword(s):  
Treatment Strategies ◽  
Brain Structures ◽  
World Health ◽  
Spinal Tumors ◽  
Central Nervous System Tumors ◽  
Clinical Scenarios ◽  
The World ◽  
Specific Factors ◽  
Health Organization ◽  
Slow Growing

Meningiomas are the most common primary central nervous system tumors and account for about one third of all primary brain and spinal tumors. They are classified according to the World Health Organization into 3 groups (I–III). Treatment strategies range from observation, surgery, and/or a radiation therapy. Many meningiomas are slow growing and discovered incidentally. Symptoms can vary widely, depending on the location. Patient’s specific factors and the location of the meningioma in relation to critical brain structures are all important factors in determining the optimal treatment. This chapter presents common clinical scenarios of meningioma. Differential diagnosis, perioperative workup, surgical nuances, and postoperative complications are discussed.

scholarly journals Imaging in the Diagnosis of Cemento-Ossifying Fibroma: A Case Series

2012 ◽  
Vol 2 ◽  
pp. 52 ◽  
Author(s):  
R Mithra ◽  
Pavitra Baskaran ◽  
M Sathyakumar
Keyword(s):  
Treatment Planning ◽  
Fibrous Dysplasia ◽  
Case Series ◽  
Disease Process ◽  
Ossifying Fibroma ◽  
Imaging Findings ◽  
The Third ◽  
Osseous Lesion ◽  
Essential Tool ◽  
Slow Growing

Cemento-ossifying fibroma is a benign fibro-osseous lesion belonging to the same category as fibrous dysplasia and cementifying dysplasia. These are slow-growing lesions that are seen in the third and fourth decades of life. Both the ossifying fibroma and cemento-ossifying fibroma represent two extremes of the same disease process since histologically both contain bone and cementum. However, the term cemento-ossifying fibroma is justified on the basis of clinical and radiological correlation. Radiographs have become an essential tool in the diagnosis of lesions in the jaw, where the anatomy is complex. Nowadays, CT provides information for diagnosis as well as treatment planning. In this case series, we report three cases of cemento-ossifying fibroma that were histologically confirmed and discuss the imaging findings.

scholarly journals Adenomatoid Odontogenic Tumour - The Master of Disguise

2021 ◽  
Vol 10 (11) ◽  
pp. 835-838
Author(s):  
Shreyas N. Shah ◽  
Falguni Patel ◽  
Vandana Shah
Keyword(s):  
World Health ◽  
Odontogenic Tumour ◽  
Odontogenic Tumours ◽  
Facial Defect ◽  
Odontogenic Epithelium ◽  
Histological Variants ◽  
Epithelial Tumour ◽  
Adenomatoid Odontogenic Tumour ◽  
Health Organization ◽  
Slow Growing

Adenomatoid odontogenic tumour, truly coined as one of the masters of disguise of orofacial pathologies, was first reported in the literature by Steen Lands.1 Philipson and Brin used the terminology adenomatoid odontogenic tumour for this pathology with its commonly accepted abbreviation AOT.2 Later on, adenomatoid odontogenic tumour (AOT) name was accepted by the World Health Organization (WHO) in 1971. In 2005, WHO revealed the histological variants of the adenomatoid odontogenic tumour and classified it as a tumour comprised of odontogenic epithelium showing various patterns in histopathologic view within a mature connective tissue stroma.3 It is seldom noticed neoplasm which comprises only 3 % of all the odontogenic tumours. It was commonly found in the maxilla with female predilection and mostly in association with impacted canines.4-6 Adenomatoid odontogenic tumour is an odontogenic epithelial tumour usually seen in females in their second decade of life. The tumour is slow growing in nature which eventually results in painless expansion of jaw. The maxilla is commonly affected than mandible. Being benign in nature, most of the AOT cases usually got treated with conservative surgical enucleation but the greater size of tumour can leave behind an oro-facial defect. To prevent such type of incident, it is important to diagnose them early and treat accordingly. Herewith, we are presenting a case report of adenomatoid odontogenic tumour of mandible in a male patient.

scholarly journals Central Giant Cell Granuloma

2019 ◽  
Vol 2 (1) ◽  
pp. 01-04
Author(s):  
Nilotpol Kashyap ◽  
Manisha Upadhyay ◽  
Rupam Tripathi ◽  
Pallavi Pawar ◽  
Ranjeet Kumar Prasad Sah ◽  
...  
Keyword(s):  
Giant Cell ◽  
Fibrous Tissue ◽  
Giant Cells ◽  
World Health ◽  
Giant Cell Granuloma ◽  
Central Giant Cell Granuloma ◽  
Bony Lesion ◽  
Benign Tumours ◽  
Health Organization ◽  
Intraosseous Lesion

Central giant cell granuloma (central giant cell granuloma) is an uncommon benign bony lesion that occurs in the mandible and maxilla and accounts for approximately 7% of all benign tumours of the jaws [1]. The World Health Organization (WHO) has defined central giant cell granuloma as an intraosseous lesion consisting of cellular fibrous tissue that contains multiple foci of haemorrhage, aggregations of multinucleated giant cells and occasional trabeculae of woven bone [2]. Central giant cell granuloma occurs predominantly in children or young adults, with approximately 75%of cases presenting before 30 years of age although presentation can occur at any age [3]. Females are affected more frequently than males, with a ratio of 2:1

scholarly journals Central ossifying fibroma, periapical cemento-osseous dysplasia and complex odontoma occurring in the same jaw

2011 ◽  
Vol 1 (2) ◽  
pp. 36 ◽  
Author(s):  
Farzaneh Agha Hosseini ◽  
Elham Moslemi
Keyword(s):  
Case Reports ◽  
Ossifying Fibroma ◽  
Pulp Tissue ◽  
Osseous Lesion ◽  
Osseous Dysplasia ◽  
Complex Odontoma ◽  
School Of Dentistry ◽  
One Year ◽  
The Right ◽  
The Relationship

Central ossifying fibroma is a rare, benign fibro-osseous lesion that arises from the periodontal ligament. Periapical cemento-osseous dysplasia is another variant of fibro-osseous lesion which occurs in the anterior region of the mandible of females. Odontoma is a benign odontogenic tumor that contains enamel, dentine cement and pulp tissue. A 46-year-old woman was referred to the Department of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, with two nonpainful swellings on both sides of the mandible, which had been slowly growing over a period of one year. Our differential diagnosis was florid cemento-osseous dysplasia, focal cemento-osseous dysplasia for the right side, complex odontoma for the left side and periapical cement-osseous dysplasia for the anterior side. The historical feature revealed ossifying fibroma, complex odontoma and periapical cemento-osseous dysplasia. The occurrence of these three lesions in the same jaw has been rarely reported in the literature. The relationship between the occurrence of these three lesions is not obvious it could be coincidental. It seems that more case reports are needed to establish the relationship between them.

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