SUN-369 Different Association of Dietary Fat Intake with Femoral Neck Strength According to Gender: A Nationwide Population-Based Study

Purpose: Despite the general belief that higher fat intake may be harmful for bone health, its impact on bone strength has not been thoroughly studied. Methods: We conducted a population-based cross-sectional study derived from the Korea National Health and Nutrition Examination Surveys, including 2,590 participants. Composite indices of femoral neck strength, such as the compression strength index (CSI), bending strength index (BSI), and impact strength index (ISI), were generated by combining bone mineral density, body mass, and height with the femoral axis length and width. Results: Dietary fat intake (%) was inversely related to CSI and ISI in men, but not in women. Men in the highest three fat intake quintiles had lower CSI, BSI, and/or ISI than those in the lowest quintile (P=0.003–0.024). In women, compared with participants in the third fat intake quintile, those in the other four quintiles had lower CSI, BSI, and/or ISI (P=0.004–0.049). When the participants were allocated to three groups according to the dietary reference intake of fat in Koreans [low (<15%), moderate (15–30%), or high (≥30%)], men with a moderate or high fat intake had significantly lower ISIs than those with a low fat intake (P=0.046 and 0.039, respectively). By contrast, compared with women consuming a moderate amount of fat, those with a high intake had lower CSI, BSI, and ISI (P = 0.025–0.047). Conclusion: These findings suggest that higher fat intake in men and low or high fat intake in women may contribute to deteriorations in bone strength.