Assessing the validity of a cross-platform retinal image segmentation tool in normal and diseased retina

Comparing automated retinal layer segmentation using proprietary software (Heidelberg Spectralis HRA + OCT) and cross-platform Optical Coherence Tomography (OCT) segmentation software (Orion). Image segmentations of normal and diseased (iAMD, DME) eyes were performed using both softwares and then compared to the ‘gold standard’ of manual segmentation. A qualitative assessment and quantitative (layer volume) comparison of segmentations were performed. Segmented images from the two softwares were graded by two masked graders and in cases with difference, a senior retina specialist made a final independent decisive grading. Cross-platform software was significantly better than the proprietary software in the segmentation of NFL and INL layers in Normal eyes. It generated significantly better segmentation only for NFL in iAMD and for INL and OPL layers in DME eyes. In normal eyes, all retinal layer volumes calculated by the two softwares were moderate-strongly correlated except OUTLY. In iAMD eyes, GCIPL, INL, ONL, INLY, TRV layer volumes were moderate-strongly correlated between softwares. In eyes with DME, all layer volume values were moderate-strongly correlated between softwares. Cross-platform software can be used reliably in research settings to study the retinal layers as it compares well against manual segmentation and the commonly used proprietary software for both normal and diseased eyes.

Factors influencing the adoption of free and open-source software for electronic records management by municipalities in Gauteng Province, South Africa

The South African cabinet adopted policy recommendations from the Government Information Technology Officer's Council pertaining to Free and Open-Source Software (FOSS). Even though the South African Cabinet has shown support for the use of FOSS through the enactment of a policy, the adoption of open source software in electronic records management seems to be slow. Proprietary software continues to be adopted and used by most public institutions, including local and provincial municipalities in South Africa. Therefore, this study aimed to investigate factors that may influence the adoption and use of FOSS for electronic records management by South African municipalities. The study adopted a qualitative research approach to collect data from 10 purposively selected municipalities in Gauteng. Data were analysed and presented thematically to address the research question. The findings of this study suggest that municipalities in Gauteng are not adopting FOSS for electronic records management as expected. This study established that top management support, reliability, affordability of the software, inadequate capability, contracts with proprietary software providers, organisational culture and organisational support are some of the factors that contributed to the low uptake when it comes to the adoption of Free and Open-Source Software by the municipalities.

chaste codegen: automatic CellML to C++ code generation with fixes for singularities and automatically generated Jacobians

Hundreds of different mathematical models have been proposed for describing electrophysiology of various cell types. These models are quite complex (nonlinear systems of typically tens of ODEs and sometimes hundreds of parameters) and software packages such as the Cancer, Heart and Soft Tissue Environment (Chaste) C++ library have been designed to run simulations with these models in isolation or coupled to form a tissue simulation. The complexity of many of these models makes sharing and translating them to new simulation environments difficult. CellML is an XML format that offers a solution to this problem and has been widely-adopted. This paper specifically describes the capabilities of chaste_codegen, a Python-based CellML to C++ converter based on the new cellmlmanip Python library for reading and manipulating CellML models. While chaste_codegen is a Python 3 redevelopment of a previous Python 2 tool (called PyCML) it has some additional new features that this paper describes. Most notably, chaste_codegen has the ability to generate analytic Jacobians without the use of proprietary software, and also to find singularities occurring in equations and automatically generate and apply linear approximations to prevent numerical problems at these points.

HBIM-GIS INTEGRATION WITH AN IFC-TO-SHAPEFILE APPROACH: THE PALAZZO TROTTI VIMERCATE PILOT CASE STUDY

The proprietary software investments in the data integration field are incrementing, and the progresses are visible in the possibility to directly open in a GIS environment a 3D software data format. Still, this is limited to the integration between the proprietary data formats and standards, ArcGIS environment shapefile multipatch and Revit 3D model, by using a proprietary software (ArcGIS). This study takes advantage of the lesson-learnt results in the proprietary data integration field, wanting to replicate a similar result using the IFC open standard, which is not directly openable by a GIS interface and needs to overcome a conversion that in most of the cases leads to semantic and geometric losses. So, an IFC-to-shapefile data conversion was performed, stressing (i) the way information is stored in the attribute table to query the geometries and perform geoprocessing, by (ii) implementing workarounds to keep the Revit instances’ shared parameters in the IFC file, (iii) meanwhile having a high Level of Detail of the HBIM. The research performed the IFC-to-shapefile data conversion through FME (Feature Manipulation Engine), benefitting of the flexibility of the shapefile format and of the IFC’ possibility to keep a high LOD in the export phase. Both allowed to properly query and manage the elements of an HBIM in a GIS (ArcGIS environment), and, using relational attributes table, retrieve the information contained in each Revit instance’ property panel, as the shared parameters that implement the BIM Level of Information (LOI).

Echoes Down the Years

This chapter examines the history of human-machine assemblages used to speak for the dead, comparing the practices of the nineteenth-century American Spiritualist movement with those of present-day transhumanist mind-uploading. In both cases, forms of mediated communication give the dead a continuing voice in society through a participatory performance involving the medium—a person whose consciousness is suspended in a state of trance, or a set of algorithms—the deceased, and an audience. Mediumship becomes a theater in which audiences both desire and interrogate the capabilities of necro-communication technology. The chapter attends to these technologies’ implied models of selfhood, which disaggregate mental content—software—from the vehicle of its expression—hardware—in the tradition of Cartesian dualism. The chapter argues that the technologies in question inevitably structure, in concerning ways, political notions of possessive individualism, which become commoditized in the shift from human-performed mediumship to selfhood instantiated in proprietary software products.