Multi T1-weighted contrast imaging and T1 mapping with Compressed sensing FLAWS at 3T

The Fluid And White matter Suppression (FLAWS) MRI sequence allows for the acquisition of multiple T1-weighted contrasts in a single sequence acquisition. However, its acquisition time is prohibitive for use in clinical practice when the k-space is linearly downsampled and reconstructed using the Generalized Autocalibrating Partially Parallel Acquisition (GRAPPA) technique. This study proposes a FLAWS sequence optimization tailored to allow for the acquisition of FLAWS images with a Cartesian phyllotaxis k-space undersampling and compressed sensing (CS) reconstruction at 3T. The CS FLAWS sequence parameters were determined using a method previously employed to optimize FLAWS imaging at 1.5T and 7T. In-vivo experiments show that the proposed CS FLAWS optimization allows to reduce the FLAWS sequence acquisition time from 8 mins to 6 mins without decreasing the FLAWS image quality. In addition, this study demonstrates for the first time that T1-weighted imaging with low B1 sensitivity and T1 mapping can be performed with the FLAWS sequence at 3T for both GRAPPA and CS reconstructions. The FLAWS T1 mapping was validated using in-silico, in-vitro and in-vivo experiments with comparison against the inversion recovery turbo spin echo and MP2RAGE T1 mappings. These new results suggest that the recent advances in FLAWS imaging allow to combine the MP2RAGE imaging benefits (T1-weigthed imaging with low B1 sensitivity and T1 mapping) and with the previous version of FLAWS imaging benefits (multi T1-weighted contrast imaging) in a single 6 mins sequence acquisition.

Quantitative Analysis of Shallow Earthquake Sequences and Regional Earthquake Behavior: Implications for Earthquake Forecasting

<p>This study is a quantitative investigation and characterization of earthquake sequences in the Central Volcanic Region (CVR) of New Zealand, and several regions in New Zealand and Southern California. We introduce CURATE, a new declustering algorithm that uses rate as the primary indicator of an earthquake sequence, and we show it has appreciable utility for analyzing seismicity. The algorithm is applied to the CVR and other regions around New Zealand. These regions are also compared with the Southern California earthquake catalogue. There is a variety of behavior within these regions, with areas that experience larger mainshock-aftershock (MS-AS) sequences having distinctly different general sequence parameters than those of more swarm dominated regions. The analysis of the declustered catalog shows that Lake Taupo and at least three other North Island regions have correlated variations in rate over periods of ~5 years. These increases in rate are not due to individual large sequences, but are instead caused by a general increase in earthquake and sequence occurrence. The most obvious increase in rate across the four North Island subsets follows the 1995-1996 magmatic eruption at Ruapehu volcano. The fact that these increases are geographically widespread and occur over years at a time suggests that the variations may reflect changes in the subduction system or a broad tectonic process. We examine basic sequence parameters of swarms and MS-AS sequences to provide better information for earthquake forecasting models. Like MS-AS sequences, swarm sequences contain a large amount of decay (decreasing rate) throughout their duration. We have tested this decay and found that 89% of MS-AS sequences and 55% of swarm sequences are better fit with an Omori's law decay than a linear rate. This result will be important to future efforts to forecast lower magnitude ranges or swarm prone areas like the CVR. To look at what types of process may drive individual sequences and may be associated with the rate changes, we examined a series of swarms that occurred to the South of Lake Taupo in 2009. We relocated these earthquakes using double-difference method, hypoDD, to obtain more accurate relative locations and depths. These swarms occur in an area about 20x20 km. They do not show systematic migration between sequences. The last swarm in the series is located in the most resistive area of the Tokaanu geothermal region and had two M =4.4 earthquakes within just four hours of each other. The earthquakes in this swarm have an accelerating rate of occurrence leading up to the first M = 4.4 earthquakes, which migrate upward in depth. The locations of earthquakes following the M = 4.4 event expand away from it at a rate consistent with fluid diffusion. Our statistical investigation of triggering due to large global (M ≥ 7) and regional earthquakes (M ≥ 6) concludes that more detailed (waveform level) investigation of individual sequences will be necessary to conclusively identify triggering, but sequence catalogs may be useful in identifying potential targets for those investigations. We also analyzed the probability that a series of swarms in the central Southern Alps were triggered by the 2009 Dusky Sound Mw = 7.8 and the 2010 Darfield Mw = 7.1 earthquake. There is less than a one-percent chance that the observed sequences occurred randomly in time. The triggered swarms do not show a significant difference to the swarms occurring in that region at other times in the 1.5-year catalog. Waveform cross-correlation was performed on this central Southern Alps earthquake catalog by a fellow PhD student Carolin Boese, and reveals that individual swarms are often composed of a single waveform family or multiple waveform families in addition to earthquakes that did not show waveform similarities. The existence of earthquakes that do not share waveform similarity in the same swarm (2.5 km radius) as a waveform family indicates that similar waveform groups may be unique in their location, but do not necessarily necessitate a unique trigger or driver. In addition to these triggered swarms in the Southern Alps we have also identified two swarms that are potentially triggered by slow-slip earthquakes along the Hikurangi margin in 2009 and 2010. The sequence catalogs generated by the CURATE method may be an ideal tool for searching for earthquake sequences triggered by slow-slip.</p>

Quantitative Analysis of Shallow Earthquake Sequences and Regional Earthquake Behavior: Implications for Earthquake Forecasting

<p>This study is a quantitative investigation and characterization of earthquake sequences in the Central Volcanic Region (CVR) of New Zealand, and several regions in New Zealand and Southern California. We introduce CURATE, a new declustering algorithm that uses rate as the primary indicator of an earthquake sequence, and we show it has appreciable utility for analyzing seismicity. The algorithm is applied to the CVR and other regions around New Zealand. These regions are also compared with the Southern California earthquake catalogue. There is a variety of behavior within these regions, with areas that experience larger mainshock-aftershock (MS-AS) sequences having distinctly different general sequence parameters than those of more swarm dominated regions. The analysis of the declustered catalog shows that Lake Taupo and at least three other North Island regions have correlated variations in rate over periods of ~5 years. These increases in rate are not due to individual large sequences, but are instead caused by a general increase in earthquake and sequence occurrence. The most obvious increase in rate across the four North Island subsets follows the 1995-1996 magmatic eruption at Ruapehu volcano. The fact that these increases are geographically widespread and occur over years at a time suggests that the variations may reflect changes in the subduction system or a broad tectonic process. We examine basic sequence parameters of swarms and MS-AS sequences to provide better information for earthquake forecasting models. Like MS-AS sequences, swarm sequences contain a large amount of decay (decreasing rate) throughout their duration. We have tested this decay and found that 89% of MS-AS sequences and 55% of swarm sequences are better fit with an Omori's law decay than a linear rate. This result will be important to future efforts to forecast lower magnitude ranges or swarm prone areas like the CVR. To look at what types of process may drive individual sequences and may be associated with the rate changes, we examined a series of swarms that occurred to the South of Lake Taupo in 2009. We relocated these earthquakes using double-difference method, hypoDD, to obtain more accurate relative locations and depths. These swarms occur in an area about 20x20 km. They do not show systematic migration between sequences. The last swarm in the series is located in the most resistive area of the Tokaanu geothermal region and had two M =4.4 earthquakes within just four hours of each other. The earthquakes in this swarm have an accelerating rate of occurrence leading up to the first M = 4.4 earthquakes, which migrate upward in depth. The locations of earthquakes following the M = 4.4 event expand away from it at a rate consistent with fluid diffusion. Our statistical investigation of triggering due to large global (M ≥ 7) and regional earthquakes (M ≥ 6) concludes that more detailed (waveform level) investigation of individual sequences will be necessary to conclusively identify triggering, but sequence catalogs may be useful in identifying potential targets for those investigations. We also analyzed the probability that a series of swarms in the central Southern Alps were triggered by the 2009 Dusky Sound Mw = 7.8 and the 2010 Darfield Mw = 7.1 earthquake. There is less than a one-percent chance that the observed sequences occurred randomly in time. The triggered swarms do not show a significant difference to the swarms occurring in that region at other times in the 1.5-year catalog. Waveform cross-correlation was performed on this central Southern Alps earthquake catalog by a fellow PhD student Carolin Boese, and reveals that individual swarms are often composed of a single waveform family or multiple waveform families in addition to earthquakes that did not show waveform similarities. The existence of earthquakes that do not share waveform similarity in the same swarm (2.5 km radius) as a waveform family indicates that similar waveform groups may be unique in their location, but do not necessarily necessitate a unique trigger or driver. In addition to these triggered swarms in the Southern Alps we have also identified two swarms that are potentially triggered by slow-slip earthquakes along the Hikurangi margin in 2009 and 2010. The sequence catalogs generated by the CURATE method may be an ideal tool for searching for earthquake sequences triggered by slow-slip.</p>

The Significance of Echo Time in fMRI BOLD Contrast: A Clinical Study during Motor and Visual Activation Tasks at 1.5 T

Blood Oxygen Level Dependent (BOLD) is a commonly-used MR imaging technique in studying brain function. The BOLD signal can be strongly affected by specific sequence parameters, especially in small field strengths. Previous small-scale studies have investigated the effect of TE on BOLD contrast. This study evaluates the dependence of fMRI results on echo time (TE) during concurrent activation of the visual and motor cortex at 1.5 T in a larger sample of 21 healthy volunteers. The experiment was repeated using two different TE values (50 and 70 ms) in counterbalanced order. Furthermore, T2* measurements of the gray matter were performed. Results indicated that both peak beta value and number of voxels were significantly higher using TE = 70 than TE = 50 ms in primary motor, primary somatosensory and supplementary motor cortices (p < 0.007). In addition, the amplitude of activation in visual cortices and the dorsal premotor area was also higher using TE = 70 ms (p < 0.001). Gray matter T2* of the corresponding areas did not vary significantly. In conclusion, the optimal TE value (among the two studied) for visual and motor activity is 70 ms affecting both the amplitude and extent of regional hemodynamic activation.

Study of Partial-Phase Steady-State Operation Modes of Phase-Shift Transformer with Hexagonal Circuit and Regulating Autotransformer

The scope of the work was the study of the phase failure operating for the new FACT’s type phase-shifting device, intended for the flexible connection of AC power systems. The mathamatical model has been developed for conducting this study. The device contains the main phase-shifting transformer based on hexagon circuit with additional regulating autotransformer, this creates the possibility of circular regulation of phase shift angle between connected systems. The model includes two 6-winding three-legs transformers, for which two sets of parameters can be independently set based on the data for the short circuit and no-load modes. The data for the direct sequence parameters is usually provided by the transformer manufacturers, and the data for the zero sequence parameters could be obtained upon additional request. As a result of modeling, the vectors of the voltages and currents were obtained in all windings in the investigated modes with supply source phase failure. This makes it possible to analyze the admissibility of such modes and estimate the need for taking special measures of protection against them. It is shown that the voltages on the windings of the main transformer insignificantly depend on the connection mode of the regulating autotransformer, while the pattern of currents distribution in the windings of the main and regulating transformers to a large extent is determined by said connection mode of the autotransformer. The presence of perceptible zero-sequence current flowing through the grounded neutrals of the power supply source and load is noticed. This fact is connected with the release of insignificant magnetic flux from the magnetic circuit in the surrounding space

Standardisation of prostate multiparametric MRI across a hospital network: a London experience

Objectives National guidelines recommend prostate multiparametric (mp) MRI in men with suspected prostate cancer before biopsy. In this study, we explore prostate mpMRI protocols across 14 London hospitals and determine whether standardisation improves diagnostic quality. Methods An MRI physicist facilitated mpMRI set-up across several regional hospitals, working together with experienced uroradiologists who judged diagnostic quality. Radiologists from the 14 hospitals participated in the assessment and optimisation of prostate mpMRI image quality, assessed according to both PiRADSv2 recommendations and on the ability to “rule in” and/or “rule out” prostate cancer. Image quality and sequence parameters of representative mpMRI scans were evaluated across 23 MR scanners. Optimisation visits were performed to improve image quality, and 2 radiologists scored the image quality pre- and post-optimisation. Results 20/23 mpMRI protocols, consisting of 111 sequences, were optimised by modifying their sequence parameters. Pre-optimisation, only 15% of T2W images were non-diagnostic, whereas 40% of ADC maps, 50% of high b-value DWI and 41% of DCE-MRI were considered non-diagnostic. Post-optimisation, the scores were increased with 80% of ADC maps, 74% of high b-value DWI and 88% of DCE-MRI to be partially or fully diagnostic. T2W sequences were not optimised, due to their higher baseline quality scores. Conclusions Targeted intervention at a regional level can improve the diagnostic quality of prostate mpMRI protocols, with implications for improving prostate cancer detection rates and targeted biopsies.

Three-phase distribution transformer connections modeling based on matrix operation method by phase-coordinates

This paper proposes a matrix operation method for modeling the three-phase transformer by phase-coordinates. Based on decoupling theory, the 12 × 12 dimension primitive admittance matrix is obtained at first employing the coupling configuration of the windings. Under the condition of asymmetric magnetic circuits, according to the boundary conditions for transformer connections, the transformers in different connections enable to be modeling by the matrix operation method from the primitive admittance matrix. Another purpose of this paper is to explain the differences of the phase-coordinates and the positive sequence parameters in the impedances of the transformers. The numerical testing results in IEEE-4 system show that the proposed method is valid and efficient.

Comparison of phase-resolved functional lung (PREFUL) MRI derived perfusion and ventilation parameters at 1.5T and 3T in healthy volunteers

Purpose The purpose of this study is to evaluate the influence of different field strengths on perfusion and ventilation parameters, SNR and CNR derived by PREFUL MRI using predefined sequence parameters. Methods Data sets of free breathing 2d FLASH lung MRI were acquired from 15 healthy subjects at 1.5T and 3T (Magnetom Avanto and Skyra, Siemens Healthcare, Erlangen, Germany) with a maximum period of 3 days in between. The processed functional parameters regional ventilation (RVent), perfusion (Q), quantified perfusion (QQuant), perfusion defect percentage (QDP), ventilation defect percentage (VDP) and ventilation-perfusion match (VQM) were compared for systematic differences. Signal- and contrast-to-noise ratio (SNR and CNR) of both acquisitions were analyzed. Results RVent, Q, VDP, SNR and CNR presented no significant differences between 1.5T and 3T. QQuant (1.5T vs. 3T, P = 0.04), and QDP (1.5T vs. 3T, P≤0.01) decreased significantly at 3T. Consequently, VQM increased significantly (1.5T vs. 3T, P≤0.01). Skewness and kurtosis of the Q-values increased significantly at 3T (P≤0.01). The mean Sørensen-Dice coefficients between both series were 0.91 for QDP and 0.94 for VDP. The Bland-Altman analysis of both series showed mean differences of 4.29% for QDP, 1.23% for VDP and -5.15% for VQM. Using the above-mentioned parameters for three-day repeatability at two different scanners and field strengths, the retrospective power calculation showed, that a sample size of 15 can detect differences of 3.7% for QDP, of 2.9% for VDP and differences of 2.6% for VQM. Conclusion Significant differences in QDP may be related to field inhomogeneities, which is expressed by increasing skewness and kurtosis at 3T. QQuant reveals only poor reproducibility between 1.5T and 3T. RVent, Q, VDP, SNR and CNR were not altered significantly at the used sequence parameters. Healthy participants with minimal defects present high spatial agreement of QDP and VDP.