Central America, made up of Honduras, El Salvador, Nicaragua, Costa Rica, and Panama, has long been a place without. Without, or beyond, the bounds of Mesoamerica and the Andes, its inhabitants have been traditionally seen as recipients of innovations, such as hierarchically structured political formations, not their creators. Consequently, the region’s cultures were defined by what they were not, Mesoamerican or Andean, and what they lacked, large cities, massive public works, imposing public art. There was little to draw the attention of researchers to Central America once the boundaries of its eye-catching neighbors were drawn. Its history presumably determined by the diffusion of ideas and practices from neighboring core states, Central America slipped into archaeological obscurity. It remains unclear whether the region constitutes a distinct culture area. This doleful account of perpetual marginality has changed as research has intensified throughout the zone since the late 1960s. Increased recognition among archaeologists that cultural boundaries are porous and that developments in one locale cannot be understood apart from events happening elsewhere helped to spur an interest in Central America’s ancient peoples. Originally motivated by a desire to clarify the reach and impact of Mesoamerican societies, research agendas are shifting across the isthmus. The varied histories of Central America’s many prehistoric and early historic cultures are now stressed along with the ways they were shaped as their members negotiated relations with people and things across interaction networks operating at scales ranging from within sites to those relations that spanned several thousand miles. The sources cited in this article draw from research conducted within what are generally treated as three geographic segments of Central America: The Southeast Lowland Maya Zone (including the monumental capitals of Copán and Quirigua); Southeast Mesoamerica (western Honduras and El Salvador), whose populations apparently maintained relatively close ties with the Maya lowlands for various periods; and Lower Central America (eastern Honduras and eastern El Salvador south through Panama), whose people largely spoke languages of the macro-Chibchan group and were weakly or indirectly involved with Mesoamerica and the Andes. These distinctions are units of convenience that continue to impact research intensities, questions, and interpretations to varying degrees. Archaeological investigations have also been affected by the civil and military disruptions from which many of the area’s populations continue to suffer. Archaeological research has been one casualty— certainly not the most important—of these events.