Theoretically, the digital economy (DE) is the core of the modern networked economic system, and in practice – a growing sector of national and world economies. The essential features of IT as a new phenomenon in the socio-economic system are complemented on an interdisciplinary basis by the epistemology of information and computer sciences, electronic technologies and platforms. This refers to the widespread use of margins (marginal costs, marginal capital, marginal labour, etc.) and concepts such as institutions, trust, risk, security, etc. The purpose of the study is to investigate the trends of economic digitalisation, theoretical and methodological changes and applied vision of economic processes. Analysis, comparison, and generalisation were used in the study. The study considers the current trends of digitalisation of the economy, which cause significant theoretical and methodological changes and a new applied vision of economic processes. In the current conditions, the actual economic laws of IT are determined by the prevailing concepts and doctrines – neoclassical and neo-institutional. It was concluded that the synergistic synthesis of the categorical framework of the economic mainstream and computer sciences allows for the development of complexity economics, which is characterised by fundamentally new dimensions and parameters.