Promising Natural Products in New Drug Design, Development, and Therapy for Skin Disorders: An Overview of Scientific Evidence and Understanding Their Mechanism of Action

The lipoxazolidinone family of marine natural products, with an unusual 4-oxazolidinone heterocycle at their core, represents a new scaffold for antimicrobial discovery; however, questions regarding their mechanism of action and high lipophilicity have likely slowed follow-up studies. Herein, we report the first synthesis of lipoxazolidinone A, 15 structural analogs to explore its active pharmacophore, and initial resistance and mechanism of action studies. These results suggest that 4-oxazolidinones are valuable scaffolds for antimicrobial development and reveal simplified lead compounds for further optimization.

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Antitubercular Marine Natural Products

Current Medicinal Chemistry ◽

10.2174/0929867324666170113120221 ◽

2018 ◽

Vol 25 (20) ◽

pp. 2304-2328 ◽

Cited By ~ 4

Author(s):

Lishu Wang ◽

Jungfeng Wang ◽

Juan Liu ◽

Yonghong Liu

Keyword(s):

Natural Products ◽

Marine Natural Products ◽

Antitubercular Activity ◽

Marine Resources ◽

Drug Candidates ◽

New Drug ◽

Chemical Constitution

Due to the importance of nature as a source of new drug candidates, the purpose of this article is to emphasize the marine natural products, which exhibit antitubercular activity, published between January 2000 and May 2016, with 138 quotations to 250 compounds obtained from marine resources. These metabolites are organized by chemical constitution and named as simple alkyl lipids derivatives, aromatics derivatives, peptides, alkaloids, terpenoids, steroids, macrolides, and polycyclic polyketides.

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Remedying the Mitochondria to Cure Human Diseases by Natural Products

Oxidative Medicine and Cellular Longevity ◽

10.1155/2020/5232614 ◽

2020 ◽

Vol 2020 ◽

pp. 1-18

Author(s):

Jian-Kang Mu ◽

Yan-Qin Li ◽

Ting-Ting Shi ◽

Li-Ping Yu ◽

Ya-Qin Yang ◽

...

Keyword(s):

Natural Products ◽

Mitochondrial Dysfunction ◽

Mechanism Of Action ◽

Current Knowledge ◽

Human Diseases ◽

Mitochondrial Regulation ◽

The Relationship

Mitochondria are the ‘engine’ of cells. Mitochondrial dysfunction is an important mechanism in many human diseases. Many natural products could remedy the mitochondria to alleviate mitochondria-involved diseases. In this review, we summarized the current knowledge of the relationship between the mitochondria and human diseases and the regulation of natural products to the mitochondria. We proposed that the development of mitochondrial regulators/nutrients from natural products to remedy mitochondrial dysfunction represents an attractive strategy for a mitochondria-involved disorder therapy. Moreover, investigating the mitochondrial regulation of natural products can potentiate the in-depth comprehension of the mechanism of action of natural products.

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Graphics computer-aided receptor mapping as a predictive tool for drug design: development of potent, selective, and stereospecific ligands for the 5-HT1A receptor

Journal of Medicinal Chemistry ◽

10.1021/jm00401a007 ◽

1988 ◽

Vol 31 (6) ◽

pp. 1087-1093 ◽

Cited By ~ 135

Author(s):

Marcel F. Hibert ◽

Maurice W. Gittos ◽

Derek N. Middlemiss ◽

Anis K. Mir ◽

John R. Fozard

Keyword(s):

Drug Design ◽

Design Development ◽

Predictive Tool ◽

Receptor Mapping ◽

Computer Aided

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Medicinal Plants and Natural Products, More Effective and Safer Pharmacological Treatment for the Management of Obesity

Current Drug Metabolism ◽

10.2174/1389200222666210729114456 ◽

2021 ◽

Vol 22 ◽

Author(s):

Harsha Negi ◽

Meenakshi Gupta ◽

Ramanpreet Walia ◽

Moayad Khataibeh ◽

Maryam Sarwat

Keyword(s):

Natural Products ◽

Weight Gain ◽

Side Effects ◽

Medicinal Plants ◽

Mechanism Of Action ◽

Pancreatic Lipase ◽

Herbal Products ◽

Prevalence Of Obesity ◽

Herbal Plants ◽

New Compounds

: Obesity is a major lifestyle disorder and it is correlated with several ailments. The prevalence of obesity has elevated over the years and it has become a global health problem. The drugs presently used for managing obesity have several side-effects associated with them such as diarrhoea, leakage of oily stools, etc. On the contrary, herbal plants and natural products are considered safe for use because they have lesser side effects. New compounds isolated from medicinal plants are screened and identified to determine their effectiveness and potential in preventing abnormal weight gain. In this review, the medicinal plants and natural materials were surveyed across the literature to cover those that have potential for managing and controlling weight gain, and their mechanism of action, active component, and experimental methodologies are also included. These herbal products can be developed as formulations for therapeutic use in obesity. The herbal plants mentioned in the review are classified based on their mechanism of action: inhibition of pancreatic lipase and appetite suppression activities. The ability to inhibit pancreatic lipase enzyme has been used to determine the effectiveness of herbal products for the prevention of abnormal weight gain because of its action on dietary fat and suppression of appetite. This review is an attempt to summarize the herbal plants and natural products that can be used to develop formulations effective in controlling weight gain and obesity.

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