A large gain variable range, high linearity, lownoise, low DC offset VGAs used in BD system

In this paper, a large gain variable range, high linearity, low noise, low DC offset VGAs with a simple gain-dB variable circuit are introduced. In the VGAs chain, the last and the first VGAs employ Bipolar transistors, to improve the linearity and noise characteristics. And the middle three stages VGAs employ MOS transistors. The whole circuitry is designed in 0.35um BiCMOS process, including variable gain amplifiers (VGAs) , fixed gain amplifiers , gain control and DC offset cancellation parts. The automatic gain control loop (AGC) provides a process independent gain variable range of 60dB (including 50dB gain-dB-linearity variable range), with a 200us loop lock time, the VGAs provide a 73dB largest gain, the THD is less than 1% at a 1V(P-P) output level; the equivalent output integral noise is 0.011v/√hz@20MHz bandwidth. The whole area is 1173um*494 um, and the power is 7.1mA at 3.3V signal supply voltage.

Patterns, Predictors, and Prognostic Value of Skeletal Muscle Mass Loss in Patients with Locally Advanced Head and Neck Cancer Undergoing Cisplatin-Based Chemoradiotherapy

Low skeletal muscle mass (SMM) is associated with toxicities and decreased survival in head and neck cancer (HNC). Chemoradiotherapy (CRT) may exaggerate loss of SMM. We investigated the changes in SMM, their predictors, and prognostic impact of SMM in patients treated with CRT between 2012 and 2018. Skeletal muscle area (SMA) segmentation was performed on pre- and post-CRT imaging. Observed changes in SMM were categorized into: (I) Stable, (II) moderate gain (III), moderate loss, (IV) large gain, and (V) large loss. In total, 235 HNC patients were included, of which 39% had stable SMM, 55% moderate loss, 13% moderate gain, 0.4% large loss, and 0.4% large gain of SMM. After CRT, SMA decreased compared to pre-CRT (31.6 cm2 versus 33.3 cm2, p < 0.01). The key predictor was a body mass index (BMI) of ≥30 kg/m2 (OR 3.6, 95% CI 1.4–9.3, p < 0.01). Low SMM at diagnosis (HR 2.1; 95% CI 1.1–4.1, p = 0.03) and an HPV-positive oropharyngeal tumor (HR 0.1; 95% CI 0.01–0.9, p = 0.04) were prognostic for overall survival. Changes in SMM were not prognostic for survival. Loss of SMM is highly prevalent after CRT and a high BMI before treatment may aid in identifying patients at risk.

LARGE GAIN METHOD IN THE PROBLEM OF SELF-ORGANIZATION OF CONTROL SYSTEMS OF STRUCTURALLY INDETERMINATE LINEAR PLANTS WITH SWITCHES. I

A method of constructing self-organizing tracking systems in the class of minimally phase linear plants operating under conditions of a priori uncertainty and structural switching is considered for the case when the main control circuit has a large gain coefficient. It is assumed that at an arbitrary point of time, the numerator and denominator of the plant transfer function can change by a jump within the previously known boundaries of their permissible values. To solve the problem of synthesizing a self-organizing plant control system with a relative degree greater than one, a dynamic corrector is used in the main contour of the system.