Malondialdehyde Meningkatkan Tingkat Antigen Khusus Prostat di Antara Pekerja Bengkel Mobil

Cadmium (Cd) is one of the environmental factors that can cause prostate cancer. Cadmium can induces metallothionein (MT) in several tissues that functions to carry out an intracellular detoxification procession by binding to Cd. Exposure of Cd can cause an increase in reactive oxygen species which will cause lipid peroxidation with the end product being malondialdehyde (MDA). The research aims to determine the correlation between MT, MDA and prostate specific antigen (PSA) among auto body repair workers. The study used a cross sectional design involving 32 auto body repair workers and their ages ranged from 18 to 66 years. Measurement of MT, MDA and PSA using the ELISA method. We performed a multiple regression analysis to evaluate the relationships between MT, MDA with PSA for age and other covariates. The mean age of subjects was 38.88 ± 12.82 years. The mean levels of MT was 2.84 ± 1.18 ng/dL, MDA was 8.22 ± 20.06 ng / dL and PSA was 0.86 ± 1.79 ng / dL. The study found that MT (β = 0,232; 95% C.I. 0,202 – 0,503; p= <0,001) and MDA (β = 0.827; 95% CI. 0.065 – 0,083; p=<0,001) significantly predicted PSA. MDA (β = 0.827) has stronger relationship with PSA compared to MT (β =0.232). This results confirmed the role of MT and MDA on PSA synthesis. Metallothionein induce the process of lipid peroxidation with the end product being malondialdehyde (MDA) and increase PSA. Keywords : auto body repair workers, metallothionein, malondialdehyde, prostate Abstrak Kadmium (Cd) merupakan salah satu faktor lingkungan yang dapat menyebabkan kanker porstat. Kadmium dapat menginduksi metalotionin (MT) di beberapa jaringan yang akan berikatan dengan Cd untuk proses detoksifikasi. Pajanan Cd dapat meningkatkan ROS yang akan meyebabkan terjadinya peroksidase lipid dengan hasil akhir malondialdehid (MDA). Penelitian bertujuan untuk mengetahui hubungan antara MT, MDA dan PSA pada pekerja bengkel mobil. Penelitian menggunakan disain kros seksional dengan subyek sebanyak 32 pekerja bengkel mobil yang berusia 18 hingga 66 tahun. Pengukuran MT, MDA dan PSA menggunakan metode ELISA. Analisis statistik menggunakan analisis regresi berganda. Rata-rata usia subyek adalah 38.88 ± 12.82 tahun. Rata-rata kadar MT 2.84 ± 1.18 ng/dL, MDA 8.22 ± 20.06 ng / dL dan PSA 0.86 ± 1.79 ng / dL. Hasil uji didapatkan MT (β = 0,232; 95% C.I. 0,202 – 0,503; p= <0,001) dan MDA (β = 0.827; 95% CI. 0.065 – 0,083; p=<0,001) berpengaruh terhadap PSA secara signifikan. MDA (β = 0.827) mempunyai hubungan dengan PSA yang lebih kuat dibanding MT (β =0.232). Hasil penelitian mengkonfirmasi adanya peran MT dan MDA pada sintesis PSA. MT menginduksi proses peroksidase lipid dengan produk akhir MDA dan meningkatkan kadar PSA. Kata kunci : pekerja bengkel mobil, metalotionin, malondialdehid, prostat

Malondialdehyde Meningkatkan Tingkat Antigen Khusus Prostat di Antara Pekerja Bengkel Mobil

Cadmium (Cd) is one of the environmental factors that can cause prostate cancer. Cadmium can induces metallothionein (MT) in several tissues that functions to carry out an intracellular detoxification procession by binding to Cd. Exposure of Cd can cause an increase in reactive oxygen species which will cause lipid peroxidation with the end product being malondialdehyde (MDA). The research aims to determine the correlation between MT, MDA and prostate specific antigen (PSA) among auto body repair workers. The study used a cross sectional design involving 32 auto body repair workers and their ages ranged from 18 to 66 years. Measurement of MT, MDA and PSA using the ELISA method. We performed a multiple regression analysis to evaluate the relationships between MT, MDA with PSA for age and other covariates. The mean age of subjects was 38.88 ± 12.82 years. The mean levels of MT was 2.84 ± 1.18 ng/dL, MDA was 8.22 ± 20.06 ng / dL and PSA was 0.86 ± 1.79 ng / dL. The study found that MT (β = 0,232; 95% C.I. 0,202 – 0,503; p= <0,001) and MDA (β = 0.827; 95% CI. 0.065 – 0,083; p=<0,001) significantly predicted PSA. MDA (β = 0.827) has stronger relationship with PSA compared to MT (β =0.232). This results confirmed the role of MT and MDA on PSA synthesis. Metallothionein induce the process of lipid peroxidation with the end product being malondialdehyde (MDA) and increase PSA. Keywords : auto body repair workers, metallothionein, malondialdehyde, prostate Abstrak Kadmium (Cd) merupakan salah satu faktor lingkungan yang dapat menyebabkan kanker porstat. Kadmium dapat menginduksi metalotionin (MT) di beberapa jaringan yang akan berikatan dengan Cd untuk proses detoksifikasi. Pajanan Cd dapat meningkatkan ROS yang akan meyebabkan terjadinya peroksidase lipid dengan hasil akhir malondialdehid (MDA). Penelitian bertujuan untuk mengetahui hubungan antara MT, MDA dan PSA pada pekerja bengkel mobil. Penelitian menggunakan disain kros seksional dengan subyek sebanyak 32 pekerja bengkel mobil yang berusia 18 hingga 66 tahun. Pengukuran MT, MDA dan PSA menggunakan metode ELISA. Analisis statistik menggunakan analisis regresi berganda. Rata-rata usia subyek adalah 38.88 ± 12.82 tahun. Rata-rata kadar MT 2.84 ± 1.18 ng/dL, MDA 8.22 ± 20.06 ng / dL dan PSA 0.86 ± 1.79 ng / dL. Hasil uji didapatkan MT (β = 0,232; 95% C.I. 0,202 – 0,503; p= <0,001) dan MDA (β = 0.827; 95% CI. 0.065 – 0,083; p=<0,001) berpengaruh terhadap PSA secara signifikan. MDA (β = 0.827) mempunyai hubungan dengan PSA yang lebih kuat dibanding MT (β =0.232). Hasil penelitian mengkonfirmasi adanya peran MT dan MDA pada sintesis PSA. MT menginduksi proses peroksidase lipid dengan produk akhir MDA dan meningkatkan kadar PSA. Kata kunci : pekerja bengkel mobil, metalotionin, malondialdehid, prostat

Monitoring and Analysis of Auto Body Precision Based on Big Data

In this paper, a Hadoop-based big data system for auto body precision is established. The system unifies the elements that affect auto body precision into a big data platform, which is more efficient than traditional management methods. Using big data analysis, we devised algorithms to improve the efficiency and accuracy of body precision monitoring. Furthermore, we developed techniques to analyze complex dimension deviation problems using a correlation analysis method, principal component analysis (PCA), and improved PCA method. We further established failure modes and devised monitoring and diagnosis models based on time series analysis.

Influence of Business Competitiveness on SMEs Performance

Small and medium enterprises (SMEs) play a pivotal role in fostering socioeconomic development especially in developing countries. They create employment opportunities, empower communities, and make positive contributions towards GDP. The objective of this study is to understand the influence of business competitiveness on SMEs performance through a case study of auto body repairs SME enterprise in Namibia referred to as ABR for confidentiality. The methodology is mixed methods with in depth literature review, and detailed multiple case studies on eleven medium sized auto-body repair enterprises. The analysis is through strategy tools supported by secondary and published data and reports. The findings reflect that although ABR has a sound credit rating with local financial institutions and there are opportunities for growth, ABR also needs to invest in equipment to become more competitive and strengthen its market.