This chapter is an overview of the regulation of healthcare in Europe. It demonstrates that regulatory mechanisms in Europe are not straightforward given the complexity of healthcare systems, the balancing of interests involved, the need to avoid political agendas taking priority over the public interest, and the financial and bureaucratic cost of compliance. Right-touch regulation in all sectors tries to strike an appropriate and proportionate balance between liberty and safety, between freedom to innovate and public protection, but the stakes are perhaps higher in healthcare than in other areas due to the potential consequences involved. However, the chapter shows how the increasing level of participation of public interest or lay representatives on regulatory boards and statutory authorities may go some way to providing the public with assurance of the independence of these bodies and their prioritisation of patient safety above all else, but much also depends on the statutory framework underpinning the work of these bodies and the extent to which they are mandated to be rigorous, independent, effective champions of the public interest. Much work has been done in this context, but, as the chapter shows, there remains much more to do.