Epsilon-Efficiency in a Dynamic Partnership with Adverse Selection and Moral Hazard

For a dynamic partnership with adverse selection and moral hazard, we design a direct profit division mechanism that satisfies ϵ-efficiency, periodic Bayesian incentive compatibility, interim individual rationality, and ex-post budget balance. In addition, we design a voting mechanism that implements the profit division rule associated with this direct mechanism in perfect Bayesian equilibrium. For establishing these possibility results, we assume that the partnership exhibits intertemporal complementarities instead of contemporaneous complementarities; equivalently, an agent’s current effort affects other agents’ future optimal efforts instead of current optimal efforts. This modelling assumption fits a wide range of economic settings.

The Dynamic Partnership of Polycomb and Trithorax in Brain Development and Diseases

Epigenetic mechanisms, including DNA and histone modifications, are pivotal for normal brain development and functions by modulating spatial and temporal gene expression. Dysregulation of the epigenetic machinery can serve as a causal role in numerous brain disorders. Proper mammalian brain development and functions depend on the precise expression of neuronal-specific genes, transcription factors and epigenetic modifications. Antagonistic polycomb and trithorax proteins form multimeric complexes and play important roles in these processes by epigenetically controlling gene repression or activation through various molecular mechanisms. Aberrant expression or disruption of either protein group can contribute to neurodegenerative diseases. This review focus on the current progress of Polycomb and Trithorax complexes in brain development and disease, and provides a future outlook of the field.

Cultural Competence and Beyond: Working Across Cultures in Culturally Dynamic Partnerships

The processes of globalisation are increasing cross-cultural interactions at exponentially faster rates and in increasingly complex ways. While these interactions can lead to much greater opportunities for positive change in all aspects of human life, they can also lead to conflict between cultures, whether overt or covert. In this article, cultural competence, a very popular framework for working across cultures, is critically examined and some of the major issues with using this framework are explored. An alternative to this framework, ‘culturally dynamic partnership’, is presented as being a more equitable and inclusive way of working across cultures. This framework builds on the strengths of earlier frameworks and presents a way of moving forwards that empowers all the participants in collaborative partnerships.

Suppression of Sertoli cell tumour development during the first wave of spermatogenesis in inhibin α-deficient mice

A dynamic partnership between follicle-stimulating hormone (FSH) and activin is required for normal Sertoli cell development and fertility. Disruptions to this partnership trigger Sertoli cells to deviate from their normal developmental pathway, as observed in inhibin α-knockout (Inha-KO) mice, which feature Sertoli cell tumours in adulthood. Here, we identified the developmental windows by which adult Sertoli cell tumourigenesis is most FSH sensitive. FSH was suppressed for 7 days in Inha-KO mice and wild-type littermates during the 1st, 2nd or 4th week after birth and culled in the 5th week to assess the effect on adult Sertoli cell development. Tumour growth was profoundly reduced in adult Inha-KO mice in response to FSH suppression during Weeks 1 and 2, but not Week 4. Proliferative Sertoli cells were markedly reduced in adult Inha-KO mice following FSH suppression during Weeks 1, 2 or 4, resulting in levels similar to those in wild-type mice, with greatest effect observed at the 2 week time point. Apoptotic Sertoli cells increased in adult Inha-KO mice after FSH suppression during Week 4. In conclusion, acute FSH suppression during the 1st or 2nd week after birth in Inha-KO mice profoundly suppresses Sertoli cell tumour progression, probably by inhibiting proliferation in the adult, with early postnatal Sertoli cells being most sensitive to FSH action.

HARMONISASI UNDANG-UNDANG DASAR 1945 DENGAN KETENTUAN INTERNASIONAL TENTANG MASYARAKAT EKONOMI ASEAN 2015 (Asean Economic Community/AEC 2015)

One form of regional cooperation is followed by Indonesia with his participation as a member of ASEAN (Association of South East Asian Nations) which was established on the basis of the Bangkok Declaration, on 8 August 1967. By the 21st century, ASEAN agreed to develop an integrated regional by forming a community of nations in Southeast Asia open, peaceful, stable and prosperous, mutual care, tied together in a dynamic partnership in 2020. Expectations are outlined in the ASEAN vision 2020 in Kuala Lumpur in 1997. To realize these expectations ratify ASEAN Bali Concord II at the 9th ASEAN Summit in Bali in 2003 which approved the establishment of an ASEAN Community (ASEAN Community) and the target is accelerated into 2015. The result shows there is disharmony between 1945 to the international provisions of the AEC 2015 in which the rules on economic issues and social welfare in 1945 are listed in Chapter XIV National Economy and social welfare, Article 33 (1), (2), (3) and (4), while based on the AEC 2015 blueprint contains four pillar framework or MEA. Disharmony both conditions contained in 4 (four) things into focus, namely the harmonization of aspects of the legal principle, an agreement on the authority, goal setting and alignment settings on the environment and surrounding communities.Keywords: Disharmony, the Constitution 1945, Asean Economic Community