Evaluation of patient and healthcare provider (HCP) knowledge, attitudes, and behavior for safety and use of pexidartinib.

e23580 Background: Pexidartinib, a kinase inhibitor, is approved for treatment of adult patients with symptomatic tenosynovial giant cell tumor (TGCT) associated with severe morbidity or functional limitations and not amenable to improvement with surgery. Due to risk of serious and potentially fatal liver injury, pexidartinib is available via a Risk Evaluation and Mitigation Strategy (REMS) Program. A requirement of the REMS is to conduct a qualitative evaluation of stakeholder Knowledge, Attitudes, and Behavior (KAB) of risks via surveys. The objective of the qualitative evaluation is to review key risk message questions with respect to understanding, relevance, clarity and provide recommendations on alternative language, phrasing, and structure. Methods: Anonymized, one-on-one 45–60-min phone interviews with patients and HCPs were conducted by UBC. Patients ≥18 y, diagnosed with TGCT (prioritized) or metastasis/sarcoma of the connective tissue, with different levels of education and fluent reading/speaking English were included. To participate, HCPs were required to treat patients with TGCT (prioritized) or metastasis/sarcoma of the connective tissue, treat patients ≥75% of their time, and clearly read/speak English. Participants were required to complete an Interview Release Form (IRF) and confirm access to a computer/tablet. Participants had little/no familiarity with pexidartinib materials. All interviews followed a standard process, used a pre-scripted guide on general instructions, confidentiality, safety event reporting, rapport building and assessment of health literacy (patients only). Feedback regarding understanding, relevance, and clarity were used to recommend potential alternate language/phrasing. To receive compensation participants were required to execute/return the IRF. Results: Twelve patients were interviewed, majority 67% had TGCT; mean age 52 y; 58% female; 42% reported some college/associates degree. 12 HCPs were interviewed, 67% treated patients with TGCT; 100% male; mean years practicing 22; all spent 75% or more time seeing patients; primary specialty Orthopedics. Areas of confusion/misunderstanding were reported, and questions were then revised. Patient findings: complexity and wordiness; HCP findings: repetition/difficulty reading, and some terminology was not self-explanatory. Conclusions: Feedback from HCPs and patients was received to improve the key risk messages of the KAB. Qualitative research is recommended to improve comprehension and data quality collected.

Evaluating Barriers to and Opportunities for Higher Education in the Hispanic Community

Although the Hispanic population in the United States is growing faster than any other ethnic group, college graduation rates, especially above the associates degree level, remain low, too low for the United States to remain academically and economically competitive in the years to come. Hispanics, on the whole, remain poorer and less educated than other ethnic groups, which could have significant economic impact on the United States, if left un-remediated, as their numbers continue to rise. Some of the questions and issues to be addressed in considering this gap in educating this population include cultural or financial barriers to attending college, bias in K-12 education and college recruitment strategies, retention and graduation issues specific to Hispanics, and high school and community college preparation of immigrant and other Hispanic students for transferring to four-year institutions.

Policy Analysis: BSN in 10

An on-going cry for decades from nurse leaders is a standardization of entry level education for Registered Nurses (RNs). The Institute of Medicine (IOM) report in 2010 spurred the requirement for an increased pool of bachelor’s prepared RNs by the year 2020 [1]. In a partnership with the Robert Wood Johnson Foundation (RWJF), the call was made by the IOM to augment the percentage of RNs with a baccalaureate degree to 80% [1, 2]. To align with the IOM recommendation, many states are in the process of developing “BSN in 10” legislation, however, New York State (NYS) was the first state to put this into law as Senate Bill S6768 [3]. This type of legislation mandates RNs with a diploma or associates degree to complete a bachelor’s program within ten years of obtaining their initial license. This paper will address the need for highly educated nurses and policy developed called “BSN in 10”, background into the Bachelor of Science in Nursing (BSN), developed policy, the stakeholders, driving political theory, and funding.

Index and Evaluation of Radar Anti-Jamming Ability Based on Improved Grey Correlation

. Greater demands are imposed on the radar anti-jamming ability by the modern warfare. How to objectively test this ability has been an important problem demanding p romp t solution by both the radar developer and the user. This paper presents a jamming evaluation system based on improved grey correlation method. First it calculates the correlation of each index of the system by using the Delphi method for processing the expert scoring, which is taken as a result of the importance of each index score, then it associates degree and importance of each index, and filter out the initial indicators; Finally, through the analysis of the correlation between the primary indicators, an effective indicator system is given. By the real data sets, the experimental results show that the improved grey correlation analysis method is superior to principal component analysis.

Form Follows Function

Role, often designated by a given title, e.g., manager, has been one of the most common means of defining occupational health nursing practice. A function based model provides an opportunity to reframe the occupational health nurse as a member of the management team. This descriptive study characterized the functions of a random sample (40%) of members of the American Association of Occupational Health Nurses from eight Midwestern states (463) in 1994. With a 78% response rate, the most frequently performed function for all respondents was “evaluate status of employees returning to work after absence” (68%). The relative frequencies for functions performed by the associates degree nurses were very similar to those for diploma nurses (r=.889 based on a perfect relationship value of 1). Subjects with baccalaureates in nursing performed more educational programming than subjects with non-nursing baccalaureates who performed more frequently in a policy area. Type of masters preparation represented different functional activities. The department to which the respondent reported affected functions. Reviewing function by salary level revealed a linear relationship with certain functions by frequency. To facilitate the investigation of the role construct based on functions, the researchers conducted a principle components analysis of the data. Four principle components were found representing groups of functions that tended to be performed by the same sets of respondents. The functions in each component tended to cluster around common skills as defined by Hersey (1988).