Abstract
Objective: To investigate the relationship between Dental Porphyromonas Concentration and Esophageal Cancer in Guangdong, China. Methods: A total of 2031 research objects were included from 2016 and follow-up for 6 years, greater than 65 years old, all are from outpatient department with esophageal foreign body sense. Data are retrospectively analyzing in year 2021. There were 43 cases found to developed esophageal cancer, 7 of them are from exposure group, (high dental porphyromonas group) and 36 from control. Two groups of individuals were retrieved from the Guangdong Provincial Hospital database between year 2016 June to 2021 June. Age, gender, race and region are strictly matched. Both of case and the controls are processing through: a. Specimen collection, b. DNA extraction, c. High-throughput sequencing (screening stage), d. Quantitative determination of target bacteria in the samples of the experimental group by Q-PCR, e. Statistical analysis of experimental data. Two sample t-test are using to detect whether have difference on concentration of Dental Porphyromonas between cases and control group. SAS 15 windows version is used as analytic tools. Results: We found that the odds on having Esophageal Cancer from high dental porphyromonas group is 1.23 times greater than controls (OR=1.23). Also, mean of concentration on Dental Porphyromonas in Esophageal Cancer Group (Cases) are statistically higher than Healthy controls, with a mean of 0.0157 in cases versus 0.0025 in controls, which is 6.54 times higher in Esophageal Group, compare with control group, with P<0.001. Where Hot Tea Drinking Habit are found associated with Esophageal Cancer, with the Odds Ratio (OR) on 1.30, as well as current smoking on an 1.13 odds ratio. Conclusion: The cohort study had found some significant associations on high Dental Porphyromonas with Esophageal Cancer Patient, where this association still lacks of proof to be a determinate causal relationship. Further greater populational longitudinal studies are need to carry out to find out more causal association, as well as finding out Dental Porphyromonas relevant Social Determinant on Esophageal Cancer.