Objective: Examining the incidence of X-monosomy among chromosomal aneuploidies with relation to cosmic background radiation. Method: We have processed the results of prenatal chromosome investigations performed in the 26-year period between 1990 and 2015. In the current study, we have paid special attention to abnormalities affecting the fetal sex chromosomes. The incidence of X-monosomy among sex chromosomal aneuploidies was studied in view of the intensity of cosmic background radiation. Results: In the 26-year period total of 43,272 fetal chromosomal investigations were carried out at our Department. In that period, sex chromosomal abnormality was detected in 230 cases (0.53 %), 92 of which (0.21 %) turned out to be X-monosomies. An uneven incidence ratio of X-monosomy could be observed as producing a wave line. As compared to nearby years, a peak was noted in 1997 (17 cases), somewhat smaller peak involving six cases was observed in 2002, likewise, 2008 yielded another small peak with five cases. Similar curves were obtained when mosaic and non-mosaic forms were studied separately. Based on the above, we looked for a mutagenic effect that could have been present in an explicit form around about the year 1997 and be associated with the higher incidence of X-monosomy in that period. An increase in the intensity of cosmic radiation could be one of those effects. The extremely high rate of chromosomal aberrations in 1997 coincided with the local minimum of the solar flares, therefore solar radiation could not be blamed for those aberrations. At the same time, however is suggestive of a causal relationship between the increase in galactic cosmic background radiation flux and higher incidence of X-monosomy around about 1997. Conclusions: Examining the incidence of sex chromosome aberrations, with special regard to X-monosomy, we have concluded the latter occurred more frequently during higher cosmic background radiation.