scholarly journals Dynamics of Human Immunodeficiency Virus-1 Genetic Diversification During Acute Infection

2020 ◽  
Vol 7 (10) ◽  
Author(s):  
Hongshuo Song ◽  
Meera Bose ◽  
Suteeraporn Pinyakorn ◽  
Eric Sanders-Buell ◽  
Anne Marie O’Sullivan ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Human Immunodeficiency Virus ◽  
Acute Infection ◽  
Viral Dynamics ◽  
Virus Envelope ◽  
Acute Infections ◽  
Human Immunodeficiency Virus Envelope ◽  
Immunodeficiency Virus ◽  
Host Genetic ◽  
Human Immunodeficiency Virus 1

Abstract We analyzed human immunodeficiency virus envelope diversity in 98 acute infections. The within-host genetic diversity, divergence from transmitted/founder (T/F) strain, and the observed frequency of multiple T/F infections increased with Fiebig stage. These data identify rapid viral dynamics during acute infection with implications for clinical trials conducted in this setting.

scholarly journals Human immunodeficiency virus 1. Predominance of a group-specific neutralizing epitope that persists despite genetic variation.

1989 ◽  
Vol 170 (5) ◽  
pp. 1681-1695 ◽  
Author(s):  
I Berkower ◽  
G E Smith ◽  
C Giri ◽  
D Murphy
Keyword(s):  
Genetic Diversity ◽  
Human Immunodeficiency Virus ◽  
Neutralizing Antibodies ◽  
Neutralizing Epitope ◽  
Vaccine Strategy ◽  
Disease Pathogenesis ◽  
Immunodeficiency Virus ◽  
High Degree ◽  
Hiv 1 ◽  
Human Immunodeficiency Virus 1

HIV-1 is known to show a high degree of genetic diversity, which may have major implications for disease pathogenesis and prevention. If every divergent isolate represented a distinct serotype, then effective vaccination might be impossible. However, using a sensitive new plaque-forming assay for HIV-1, we have found that most infected patients make neutralizing antibodies, predominantly to a group-specific epitope shared among three highly divergent isolates. This epitope persists among divergent isolates and rarely mutates, despite the rapid overall mutation rate of HIV-1, suggesting that it may participate in an essential viral function. These findings, plus the rarity of reinfections among these patients, suggest that HIV-1 may be more susceptible to a vaccine strategy based on a group-specific neutralizing epitope than was previously suspected.

Human immunodeficiency virus envelope glycoprotein 120 alters sleep and induces cytokine mRNA expression in rats

1996 ◽  
Vol 271 (2) ◽  
pp. 1-1 ◽  
Author(s):  
M. R. Opp ◽  
P. L. Rady ◽  
T. K. Hughes ◽  
P. Cadet ◽  
S. K. Tyring ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Mrna Expression ◽  
Envelope Glycoprotein ◽  
Cytokine Mrna ◽  
Virus Envelope ◽  
Cytokine Mrna Expression ◽  
Human Immunodeficiency Virus Envelope ◽  
Immunodeficiency Virus

Pages R963–R970: M. R. Opp, P. L. Rady, T. K. Hughes, Jr., P. Cadet, S. K. Tyring, and E. M. Smith. “Human immunodeficiency virus envelope glycoprotein 120 alters sleep and induces cytokine mRNA expression in rats.” On p. R968, Fig. 3 should appear as below. (See PDF)

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