(E)-1-(3-Benzoyl-4-phenyl-1H-pyrrol-1-yl)-3-phenylprop-2-en-1-one

Over the last decade, there has been an increasing effort to fight inflammatory conditions establishing new multitarget approaches. Chronic inflammation is implicated in many multifactorial diseases, constituting a great economic burden and a chronic health problem. In an attempt to develop new potent multifunctional anti-inflammatory agents, a cinnamic-pyrrole hybrid (6) was synthesized and screened for its antioxidant and anti-Lipoxygenase potential. The new compound, in comparison with its pyrrole precursor (4), showed improved biological activities. In silico calculations were performed to predict its drug-likeness. The examined derivative is considered orally bioavailable according to Lipinski’s rule of five. Compound 6 could be used as a lead for the synthesis of more effective hybrids.

Women’s Awareness and Associated Factors on Preconception Folic Acid Supplementation in Adet, Northwestern Ethiopia, 2016: Implication of Reproductive Health

Introduction. Preconception folic acid supplementation is the provision of folate for reproductive age group women who have a plan to be pregnant. According to different studies, in African countries, there is poor utilization of preconception folic supplementation. So this study aimed at assessing women’s awareness on preconception care and its associated factors in Adet, Northwestern Ethiopia. Methods. A community-based cross-sectional study was conducted from March 1 to April 1, 2016, among 422 reproductive age group women. Systematic random sampling was used to get the study unit, and the data were collected using pretested structured questionnaire via face-to-face interview. The collected data were entered, cleaned, checked using EpiData version 3.1, and finally analyzed using SPSS version 20. Descriptive summary of the data was presented in terms of percentage and frequency. Binary and multiple logistic regressions were used in order to identify predictors using odds ratio at 95% confidence interval. Result. In this study, a total of 422 reproductive age group women participated with a response rate of 100%. Of a total of 422 participants, 67 (15.9%) of the women had good awareness on preconception folic acid supplementation. Women’s awareness on preconception folic acid supplementation was affected by having a chronic health problem, monthly household income, educational status, and a history of family planning use. Women who were educated (AOR 4.77, CI 1.85–6.98), had a history of family planning use (AOR 3.89, CI 1.77–8.55), had a chronic health problem (AOR 3.47, CI 2.68–5.98), and had a better monthly income (AOR 2.6, CI 2.05–6.76) had good awareness than their counterparts. Conclusion and Recommendation. This study concluded that women’s awareness on preconception folic acid supplementation was low. This finding suggests that there is a need to give emphasis and deliver health education about preconception folic acid supplementation for women.

Mathematical Model for Forecasting the Influence of Atmospheric Pollution on Population Morbidity in Stara Zagora Municipality (Bulgaria)

AIM: This paper aims to create a mathematical model for forecasting the morbidity of the population in the Republic of Bulgaria and the Stara Zagora Municipality in particular as a consequence of the atmospheric pollution.SUBJECTS AND METHODS: This model is based on a formula which determines the correlation between the average annual concentrations of atmospheric pollutants SO2, PM10, Pb aerosols, NO2 and H2S) and the morbidity of the population based on the number of people who visited their GPs in a relation with a chronic health problem or emergency condition and the number of hospitalisations in two age groups (newborn to 17 years olds and 18 and older) as well as for the entire population in the period 2009-2013, making it possible to predict morbidity levels.RESULTS: The expected morbidity level predictions based on the number of people who visited their GPs in Municipality are lower, while hospitalisation level predictions are higher. This model has been created and tested and is applicable in all residential areas.CONCLUSIONS: A new, very sensitive, mathematical model has been created and tested (average margin of error from 0.61% to 2.59%) and is applicable in all residential areas.

Exercise, physical activity, eating and weight disorders

Obesity is a highly visible yet neglected chronic health problem affecting developed and developing nations, particularly nations undergoing nutritional transition. The term ‘globesity’ has been coined to describe this international phenomenon, which primarily results from persistent energy imbalance typically characterized as reduced energy expenditure relative to energy intake. Conversely, disordered eating characterized by low energy intake, which is often paired with high levels of energy expenditure, are features of the opposite extreme to obesity and can manifest as eating disorders like anorexia nervosa or bulimia nervosa. Identification, treatment, and management of young people along the spectrum from frank eating disorders represents a persistent and growing health challenge. This chapter provides an overview of the range of factors contributing to inappropriate eating and activity disorders in childhood and adolescence, and how these problems might be managed.