REVIEW OF THE INTERNATIONAL CLASSIFICATION OF RARE DISEASES

The article describes the principles of the international classification of rare diseases, proposed by the organization Orphanet. The supranosological nature of rare diseases predetermined the task of developing their new classification, which is more convenient for coding in the framework of their treatment than ICD-11, but coordinated with it. For these purposes, the international organi- zation Orphanet, formed in France in 1997, together with WHO, is developing an additional classification of rare diseases with the assignment of each noso- logical unit its own unique code based on the collection of information and the formation of its own database of their nomenclature. The Orphanet nomencla- ture includes the following elements: a unique Orpha disease code, a common or most common disease name, synonymous disease names, keywords often used to search for a given disease, if any, and the disease definition itself.

A study of aerial courtyard of super high-rise building based on optimisation of space structure

The independent super high-rise building weakens and reduces the cooperation of functional subsystems. Implanting aerial courtyards could improve the aerial environment of that corresponding floor and enable the plane courtyards to be stereoscopic. Constructing multiple aerial courtyard-centred functional clusters of higher floors can optimise the overall space structural relationship. The paper uses the space syntax theory to discuss how to construct holistically linked aerial courtyards in a super high-rise building and applies the Grasshopper-based space syntax arithmetic logical unit to analyse and calculate the aerial courtyard of super high-rise building in different space structure modes, and also proposes design optimisation strategies based on these analyses. The paper points out that by setting aerial courtyard between vertical transportation space and functional space, establishing a direct connection between adjacent aerial courtyards, arranging vertical transportation space dispersedly and so on, it is possible to promote vertical cooperative effect, enhance integration and intelligibility of entire space structure, and provide guidelines and foundation for the construction of vertical cities.

Performance Efficient Alu using Finfet

According to the prophecy of Moore, the concentration of transistors in an integrated circuit doubles every two years. But this is limited by the technologies used in the fabrication of integrated circuits, as the systems are scaled down. FinFET technology aims to combat this challenge. The construction of power efficient high speed Arithmetic & Logical Unit (ALU) using FinFET technology is proposed in this paper. Proposed FinFET based ALU is designed with arithmetic functions like high speed addition, multiplication and logical functions such as AND and XOR. Simulation results of the proposed power efficient high speed FinFET ALU proves to be better with a power saving of 80.5%. FinFET has the advantage of providing low power without compromising on the Performance. The power analysis for ALU is done using CADENCE-VIRTUOSO, which is known for its accuracy.

Temporal Performance Analysis of Enhanced 8 Bit RISC Architecture

In this paper, we have proposed the development of the Enhanced 8-bit RISC architecture and the temporal performance analysis of the enhanced architecture. The enhanced 8 bit RISC architecture is powered with the additional block called as Co-operative Arithmetic and Logical Unit (CALU). The 8 bit core is designed using FPGA as SPARTAN-6 XC65LX9-3TQG144. The purpose of designing is to integrate number of instructions with additional instructions, which are 16 bits with keeping all original instructions execution having 8 bit format. We have designed the enhanced of 8 bit processor for improvement in speed as well as to speedup of the execution cycle, so that improvement in clock cycles per second for execution of an instruction. The Enhanced RISC architecture is fully compatible with the original core along with old instruction set. The CALU is designed to enhance the multi-byte capabilities of the core. The performance improvement in terms of the clock cycle savings has been recorded. The performance enhancement of average 71% has been recorded by the Enhanced core. The Enhanced RISC core has been developed and simulated on Xilinx Vivado 2017.3.