Early life environmental factors associated with autism spectrum disorder symptoms in children at age 2 years: A birth cohort study

Mounting evidence finds that early life environmental factors increased the probability of autism spectrum disorder. We estimated prospective associations between early life environmental factors and autism spectrum disorder symptoms in children at the age of 2 years in a population-derived birth cohort, the Barwon Infant Study. Autism spectrum disorder symptoms at the age of 2 years strongly predicted autism spectrum disorder diagnosis by the age of 4 years (area under curve = 0.93; 95% CI (0.82, 1.00)). After adjusting for child’s sex and age at the time of behavioural assessment, markers of socioeconomic disadvantage, such as lower household income and lone parental status; maternal health factors, including younger maternal age, maternal pre-pregnancy body mass index, higher gestational weight gain and prenatal maternal stress; prenatal alcohol; environmental air pollutant exposures, including particulate matter < 2.5 µm at birth, child secondhand tobacco smoke exposure at 12 months, dampness/mould and home heating with oil, kerosene or diesel heaters at 2 years postnatal. Lower socioeconomic indexes for area, later birth order, higher maternal prenatal depression, and maternal smoking frequency had a dose-response relationship with autism spectrum disorder symptoms. Future studies on environmental factors and autism spectrum disorder should consider the reasons for the socioeconomic disparity and the combined impact of multiple environmental factors through common mechanistic pathways. Lay abstract Mounting evidence indicates the contribution of early life environmental factors in autism spectrum disorder. We aim to report the prospective associations between early life environmental factors and autism spectrum disorder symptoms in children at the age of 2 years in a population-derived birth cohort, the Barwon Infant Study. Autism spectrum disorder symptoms at the age of 2 years strongly predicted autism spectrum disorder diagnosis by the age of 4 years (area under curve = 0.93; 95% CI (0.82, 1.00)). After adjusting for child’s sex and age at the time of behavioural assessment, markers of socioeconomic disadvantage, such as lower household income and lone parental status; maternal health factors, including younger maternal age, maternal pre-pregnancy body mass index, higher gestational weight gain and prenatal maternal stress; maternal lifestyle factors, such as prenatal alcohol and environmental air pollutant exposures, including particulate matter < 2.5 μm at birth, child secondhand tobacco smoke at 12 months, dampness/mould and home heating with oil, kerosene or diesel heaters at 2 years postnatal. Lower socioeconomic indexes for area, later birth order, higher maternal prenatal depression and maternal smoking frequency had a dose-response relationship with autism spectrum disorder symptoms. Future studies on environmental factors and autism spectrum disorder should consider the reasons for the socioeconomic disparity and the combined impact of multiple environmental factors through common mechanistic pathways.

Cascade control of «smart home» heating

The article discusses the issues of implementing the conversion of input signals of «smart» sensors for automation of the heating system, an algorithm for calculating the parameters of measuring circuits with a nonlinear element and an operational amplifier is developed. The issues of modeling cascade control of residential building heating systems are investigated. The results of the analysis and selection of parameters of the cascade control system are presented. An algorithm implementing the operation of a virtual object is given. The structures of management of residential building objects are proposed. The method of calculating the adjustment of the controller for cascade control is given. For the heating system stand, the procedure for setting the parameters of the process of PID control of the coolant temperature is considered. The results confirming the achievability of the proposed structural changes are obtained. The results of experimental studies are presented.

PRACTICAL IMPLEMENTATION OF THE SMART HOME HEATING MANAGEMENT SYSTEM

The article deals with the issues of modeling and management of residential building heating systems. A heating system stand has been created for testing the proposed automation systems. The description of the hydraulic, electrical and software parts of the stand is given. To control the work of the stand, a controller implemented on the Arduino platform is proposed. The results of experi-mental studies are presented.

DYNAMICS OF THE TEMPERATURE SENSOR OF THE «SMART HOME» HEATING SYSTEM

The article deals with the issues of modeling the control of room heating. The dynamics of the object-the heating system of a residential building-is obtained. The equation of the dynamics of the temperature sensor is derived. Dynamic errors are determined by the dynamic characteristics of the temperature sensor. The dynamic error is determined for a stepwise change in the input signal.

Valuing Warm Homes - Exploring New Zealanders' Home Heating Choices

<p>New Zealand homes have a record of being poorly heated and inadequately energy efficient. While policy makers increasingly recognise the many benefits associated with energy efficient warm homes, there is currently a lack of understanding of how New Zealanders make choices about space heating. This thesis takes a mixed method approach in order to 1) understand how New Zealanders value energy efficient heating and 2) further explore how people make decisions about home heating. Capturing the economic value of the range of benefits associated with home heating is investigated through analysing a contingent valuation study undertaken by the Housing, Heating and Health Study (University of Otago). Participants show 'willingness to pay' and related values below heater market prices. It is argued that there is some indication of split incentives issues and income constraint, and increased familiarisation with space heaters may increase willingness to pay. Evidence from focus group research suggests that while attitudes and norms are conducive to efficiently heated homes, other market and non-market factors impede pro-environmental choices. The widely recognised Kiwi stoicism of living in cold homes is not evidenced; choosing to go cold in the home may instead be rationalised as mitigating the environmental impacts associated with heating. This analysis sheds light on how intervention and how provision of information to fill the 'energy efficiency gap' could move outside the 'rational person' model of how New Zealanders make home heating choices.</p>

Valuing Warm Homes - Exploring New Zealanders' Home Heating Choices

<p>New Zealand homes have a record of being poorly heated and inadequately energy efficient. While policy makers increasingly recognise the many benefits associated with energy efficient warm homes, there is currently a lack of understanding of how New Zealanders make choices about space heating. This thesis takes a mixed method approach in order to 1) understand how New Zealanders value energy efficient heating and 2) further explore how people make decisions about home heating. Capturing the economic value of the range of benefits associated with home heating is investigated through analysing a contingent valuation study undertaken by the Housing, Heating and Health Study (University of Otago). Participants show 'willingness to pay' and related values below heater market prices. It is argued that there is some indication of split incentives issues and income constraint, and increased familiarisation with space heaters may increase willingness to pay. Evidence from focus group research suggests that while attitudes and norms are conducive to efficiently heated homes, other market and non-market factors impede pro-environmental choices. The widely recognised Kiwi stoicism of living in cold homes is not evidenced; choosing to go cold in the home may instead be rationalised as mitigating the environmental impacts associated with heating. This analysis sheds light on how intervention and how provision of information to fill the 'energy efficiency gap' could move outside the 'rational person' model of how New Zealanders make home heating choices.</p>

Carbon Monoxide Poisoning in Kuwait: A Five-Year, Retrospective, Epidemiological Study

Background: Carbon monoxide (CO) poisoning is a major public health concern and a common cause of death worldwide. However, to our knowledge, no studies have been conducted on CO poisoning exposure and mortality in Kuwait. Objectives: Using epidemiological and forensic data analysis, we investigated the prevalence and characteristics of CO poisoning-associated deaths in Kuwait over five years (2014–2018), using official police data. Methods: The Forensic Toxicology Laboratory analyzed 203 blood specimens of deceased individuals for potential CO poisoning during the study period. We obtained demographic information of the deceased and other information regarding the source of the CO, the type of death and the seasonal and geographical distribution of fatalities. The percentage of carboxyhemoglobin (COHb%) was assessed using a CO-oximeter. Results: CO poisoning was confirmed in ~29% (59 cases) of the analyzed specimens, of which CO poisoning was accidental in the majority of cases (~95%) and homicidal in the remaining of cases (~5%), with no reported suicides. The five-year cumulative mean of COHb% in the blood specimens of the 59 confirmed cases was ~63%. Most of the deceased were males (~68%). The mean age of male and female victims per year were similar (~23–38 years). Fatalities were more common (~44%) during the winter (December–February). Uncontrolled home fires and coal stoves contributed to the primary sources of CO poisoning at 61% and 22%, respectively. Recommendations: Based on our findings, we propose that the local government should mandate the installation of smoke alarms and CO detectors in residential settings and endorse health education, informing the local population about the causes of fire and potential for CO poisoning, with an emphasis on prevention. Practical measures that can be applied include proper installation and regular maintenance of home-heating appliances and appropriate ventilation. The present study could greatly benefit the government in directing efforts toward decreasing CO poisoning incidents in Kuwait in the future.