In medicine, there are very large numbers of models of different pathological processes. Thus, models of the evolution of pathologies, in particular, in the clinic of nervous diseases absent altogether. This work presents an example of mathematical modeling the development of pathology in the human body in the form of transition from postural tremor to periodic tremor Parkinson´s and further to a rigid form. The appearance of periodicity in the characteristics of the neuromuscular system corresponds to the pathological phenomenon, for example, Parkinson´s disease. The authors note the similarity of tapping in relatively healthy person with a tremor of a patient with Parkinson´s disease from the position of the phase portraits. At high excitations from the striatum in patients with Parkinson´s disease (in models is Ш=410 u.e.) in the cluster of the neuromuscular system comes rigid phase and in the effector system there is a severe form of parkinsonism, the muscles can no longer perform any movements. In this case the timebase activity of effector organs moves in a steady mode and takes some constant value. The simulation results suggest the high consistency of the obtained results with real signals recorded by the subjects in different conditions. For various indicators of the functional systems of the human body, it is necessary to find the coefficients b and ud directionally.