This chapter in the Oxford Handbook of Emergency Medicine investigates wounds, fractures, and orthopaedics in the emergency department (ED). It reviews classification and assessment of skin wounds, puncture wounds, and foreign bodies, and discusses wound cleaning, closure, aftercare, infected wounds, bites and stings, tetanus, and needlestick injury. It explores fractures, including open (compound) fracture and dislocation (and subluxation), casts and their problems, and osteoporosis, as well as soft tissue injury, physiotherapy in the ED, and fracture clinic and alternatives. It describes different areas of fracture and injury in detail, including hand, thumb, scaphoid, and carpal injury, Colles’ fracture, Smith’s fracture, Barton’s and reverse Barton’s fracture, wrist injury, forearm fracture, elbow injury, humeral fracture, shoulder dislocation, clavicle injury, neck injury, facial wounds, pelvic fracture, hip dislocation, sacral and coccygeal fracture, femur fracture, knee injury, tibial and fibular shaft fracture, pretibial laceration, calf and Achilles tendon injury, ankle injury, foot fracture and dislocation, toe injury, low back pain, arthritis, and eponymous fractures.