Steering Mast Cells or Their Mediators as a Prospective Novel Therapeutic Approach for the Treatment of Hematological Malignancies

Tumor cells require signaling and close interaction with their microenvironment for their survival and proliferation. In the recent years, Mast cells have earned a greater importance for their presence and role in cancers. It is known that mast cells are attracted towards tumor microenvironment by secreted soluble chemotactic factors. Mast cells seem to exert a pro-tumorigenic role in hematological malignancies with a few exceptions where they showed anti-cancerous role. This dual role of mast cells in tumor growth and survival may be dependent on the intrinsic characteristics of the particular tumor, differences in tumor microenvironment according to tumor type, and the interactions and heterogeneity of mediators released by mast cells in the tumor microenvironment. In many studies, Mast cells and their mediators have been shown to affect tumor survival and growth, prognosis, inflammation, tumor vascularization and angiogenesis. Modulating mast cell accumulation, viability, activity and mediator release patterns may thus be important in controlling these malignancies. In this review, we emphasize on the role of mast cells in lymphoid malignancies and discuss strategies for targeting and steering mast cells or their mediators as a potential therapeutic approach for the treatment of these malignancies.

To the methods for actualization of main stands parameters of hardwood tree species of Ukraine

Continuous forest inventory, as one of the methods of forest management of the country, in contrast to the basic inventory, has a number of advantages, which primarily provide the opportunity to obtain the most complete and reliable information about the current state of the forest, as it provides annual updates of main stands parameters of forest found on Ukraine. Hardwood tree species (oak, ash, beech, hornbeam, etc.) occupy a special place among all that grow in Ukraine and occupy almost 44 % of the forest area covered with forest vegetation. According to the latest state forest inventory as of 01.01.2011, hardwood tree species are dominated by oak stands - 62.6 % of the area of all hardwood tree species, forest beech - 20.2 %, hornbeam - 3.2 % and ash ordinary, forming mainly mixed stands with oak. A systematic approach to the effective solution of the problem of continuous forest inventory requires the development of objective methods and mathematical models for updating the main stands parameters of forests. In Ukraine, for actualization main stands parameters, two methods have been developed to forecast their growth. The first is based on modeling the percentage of current increment by average height and wood stock, the second - on the developed dynamic site index curves and yield tables for modal stands. The aim of the work is to improve the methodological approaches to modeling the growth prognosis of the main stands parameters by the second method. To achieve these goals used the method of nonlinear regression using IBM SPSS Statistics. As a result of the conducted researches it was offered to model a new unified ratio of the stands parameter a year ahead to the same stands parameter now multiplied by the age of the stand to model the growth prognosis for all stands parameters. This made it possible during the simulation to describe the changes in growth by the main stands parameters with almost absolute accuracy (the coefficient of determination of the obtained models is 1.0). The equation obtained for growth prognosis has the same form for stands of all tree species, of different origin, composition and site index classes.

A Concise Review on Targeted Therapy for Oral Cancer

Oral Cancer has become a center of attraction in the world, causing health problems. Carcinoma that involves the lip, tongue, mouth surface, palate, and throat is also serious if not diagnosed and treated. Current treatment strategies involve surgical removal, using chemotherapeutic drugs and radiation therapy. The event of targeted therapy aid in medicine together with oral cancers is that the basic dependence of neoplasm cells on biological pathways which might be coupled to medicine that inhibit those pathways. The resistance of tumor cells to anticancer drugs is a known method which is investigated experimentally at the molecular level. Immunotherapeutic agent resistance is thought to affect the efficacy of anticancer remedies. The induced or intrinsic drug resistance has a strong effect on the survival and cancer growth prognosis by suppression of cancer-associated cell signaling pathways of cancer patients. Targeted therapy also has a significant inhibitory ability, thus demonstrating the high quality of treatment. Hence this concise review discusses the implementation of molecular targeted therapy in the treatment of oral cancer.