Adsorption is widely acknowledged as one of the best options that are available for the removal of contaminants from water. Contamination of water does not only create water scarcity, but it has the capacity to generate and transfer several environmental problems including threat to public health. This chapter reviewed calcium oxide nanoparticle (CaONP) as a noble metal oxide for the removal of contaminants from water. The review is concentrated in the general overview of water contamination, metal oxide nanoparticles, general application of CaONP, synthetic methods, characterization method, and applications. The chapter observed that little is done on the use of CaONP for the removal of contaminants from water except for dyes, some heavy metal ions, and few organic/inorganic compounds. It is also observed that CaONP can be applied as adsorbent and in photocatalytic degradation of dye. Suggestions are made on the possibility of utilizing local raw materials that are easily accessible, cheap, and environmental sources of raw materials for the synthesis of CaONP.