<p>Fractured and karstified carbonate rocks are important targets for the hydrocarbon exploration industry as they usually represent very productive reservoirs. Most of the karst features in carbonate reservoirs are the result of rising fluid flow in deeply buried settings (i.e., hypogenic karst), whose origin and solutional efficiency are not connected to surface processes. Hypogenic conduits are often intercepted by drilling during hydrocarbon exploration, and their occurrence is sometimes associated with high-permeability horizons characterized by intense silicification. Silicification is a common diagenetic process in sedimentary basins, in which Si-rich fluids modify textures, mineralogy, and petrophysical properties of the host rock. &#160;</p><p>We present the preliminary results of a multidisciplinary study performed in a cave developed within a mixed carbonate-siliciclastic succession of the Salitre Formation, in Northeastern Brazil (Calixto Cave). This cave offers the opportunity to study an accessible and extensive (more than 1 km long) conduit system associated with silicification. We performed a detailed stratigraphic and structural characterization of the sedimentary sequence in the cave, identifying different SiO<sub>2</sub> facies and textural associations. Furthermore, we described cave geometry and pattern by topographic and morphometric observations using terrestrial laser scanner 3D models. Petrographic observations at the optical microscope were complemented with porosity-permeability analyses on rock plugs, XRD, XRF, and SEM-EDX analyses to highlight composition and petrophysical properties of the different lithostratigraphic units in the cave.</p><p>We found that silicification and mechanical stratigraphy determined the formation of high-permeability and seal units, whose distribution was fundamental for controlling paleo-flow pathways, karstification, and the spatial-morphological organization of the resultant conduit system. Cave morphologies, evidence of silica dissolution, crystalline quartz deposits and their associated paragenesis suggest that the speleogenetic phase contributing to the main karst formation happened in deeply buried hypogenic conditions, involving rising alkaline fluids probably of hydrothermal origin.</p>