Lorentz Scanning Electron/Ion Microscopy

We have developed an observation and measurement method for spatial electromagnetic fields by using scanning electron/ion microscopes, combined with electron holography reconstruction technique. A cross-grating was installed below the specimen, and the specimens were observed under the infocus condition, and the grating was simultaneously observed under the defocus condition. Electromagnetic fields around the specimen were estimated from grating-image distortions. This method is effective for low and middle magnification and resolution ranges; furthermore, this method can in principle be realizable in any electron/ion beam instruments because it is based on the Lorentz force model for charged particle beams. Mini Abstract We have developed a visualization technique for spatial electromagnetic fields by using scanning electron/ion microscopes, combined with electron holography reconstruction technique. A specimen and a cross-grating installed below the specimen were observed simultaneously. The distorted grating image caused by electromagnetic fields around the specimen were quantitatively measured and visualized.

Biological Rationale and Clinical Evidence of Carbon Ion Radiation Therapy for Adenoid Cystic Carcinoma: A Narrative Review

Adenoid cystic carcinoma (ACC) is a rare, basaloid, epithelial tumor, arising mostly from salivary glands. Radiation therapy can be employed as a single modality for unresectable tumors, in an adjuvant setting after uncomplete resection, in case of high-risk pathological features, or for recurrent tumors. Due to ACC intrinsic radioresistance, high linear energy transfer (LET) radiotherapy techniques have been evaluated for ACC irradiation: while fast neutron therapy has now been abandoned due to toxicity concerns, charged particle beams such as protons and carbon ions are at present the beams used for hadron therapy. Carbon ion radiation therapy (CIRT) is currently increasingly used for ACC irradiation. The aim of this review is to describe the immunological, molecular and clinicopathological bases that support ACC treatment with CIRT, as well as to expose the current clinical evidence that reveal the advantages of using CIRT for treating ACC.

A novel non-adiabatic approach to transition crossing in a circular hadron accelerator

Crossing the transition energy is always a delicate process, representing a potential source of strong perturbations of the dynamics of charged particle beams in a hadron circular accelerator. Since the first generation of multi-GeV rings, intense studies have been devoted to understanding the possible harmful mechanisms involved in transition crossing and to devise mitigation measures. Nowadays, several circular particle accelerators are successfully operating across the transition energy and this process is well mastered. In a completely different context, stable resonances of the traverse phase space have been proposed as new means of manipulating charged particle beams. While the original aim of such a proposal was multi-turn extraction from the CERN Proton Synchrotron to the Super Proton Synchrotron, many more applications have been proposed and studied in detail. In this paper, the two topics, i.e. transition crossing and stable resonances, have been brought together with the goal of providing a novel and non-adiabatic approach to perform a clean transition crossing. The idea presented here is that by judiciously using sextupoles and octupoles it is possible to generate stable islands of the horizontal phase space. These islands represent a second closed orbit whose properties can be selected independently of those of the standard, i.e. central, closed orbit. This provides a means of performing a non-adiabatic change of the transition energy experienced by the charged particles by displacing the beam between the two closed orbits.

Cyclotron trap

The cyclotron trap was developed at SIN/PSI to increase the stopping density of negatively charged particle beams for the formation of exotic atoms in low pressure gases. A weak focusing magnetic field, produced by superconducting solenoids, is used. Particles are injected radially through the fringe field to a moderator, which decelerates them into orbits bound by the field. Further deceleration by moderators and/or low-pressure gases leads the particles to the centre of the device, where they can be stopped or eventually extracted. Experiments became feasible with this technique, such as those dealing with pionic hydrogen/deuterium at SIN/PSI. Muonic hydrogen laser experiments also became possible with the extraction of muons from the cyclotron trap. The formation of antiprotonic hydrogen in low pressure targets led to successful experiments at LEAR/CERN.

Cancer of the External Auditory Canal with Extensive Osteoradionecrosis of the Skull Base after Re-Irradiation with Particle Beams: A Case Report

Re-irradiation with X-rays and particle beams can be used to treat localized recurrence of unresectable head and neck cancer after initial irradiation therapy. However, re-irradiation therapy increases the risk of severe and late sequelae by 4-to 8-fold. It can also result in fatal outcomes, such as rupture of the carotid artery and cerebral necrosis or abscess. A 41-year-old woman was diagnosed with squamous cell carcinoma of the external auditory canal. The patient was initially treated with X-ray irradiation. However, the patient underwent re-irradiation with heavy particle beams and neutron rays for a recurrent tumor. The patient developed necrosis of the skull base involving the facial skin and temporal bone 2 months after the last session of re-irradiation therapy. The tissue in the parapharyngeal and masticatory regions also became completely necrotic, resulting in extensive exposure of the brain parenchyma. Although the patient underwent conservative and surgical treatment, necrosis of the tissue progressed, and a large part of the brain was exposed. Approximately 2.5 years later, although the brain is still exposed, the patient is alive without disease. Although the tumor had subsided and long-term survival was achieved, our patient developed serious osteoradionecrosis of the skull base with extensive brain exposure. For patients who are not candidates for surgery, re-irradiation alone is an option, albeit with poor prospects. This approach should be discussed with the patient while balancing the potential survival gain against the burden of treatment and the risk of complications.

An Active Plasma Beam Dump for EuPRAXIA Beams

Plasma wakefields driven by high power lasers or relativistic particle beams can be orders of magnitude larger than the fields produced in conventional accelerating structures. Since the plasma wakefield is composed not only of accelerating but also of decelerating phases, this paper proposes to utilize the strong decelerating field induced by a laser pulse in the plasma to absorb the beam energy, in a scheme known as the active plasma beam dump. The design of this active plasma beam dump has considered the beam output by the EuPRAXIA facility. Analytical estimates were obtained, and compared with particle-in-cell simulations. The obtained results indicate that this active plasma beam dump can contribute for more compact, safer, and greener accelerators in the near future.