Simulation of Density and Flow Dynamics in a Lagoon Aquifer Environment and Implications for Nutrient Delivery From Land to Sea

The near coastal zone, hosting the saltwater-freshwater interface, is an important zone that nutrients from terrestrial freshwaters have to pass to reach marine environments. This zone functions as a highly reactive biogeochemical reactor, for which nutrient cycling and budget is controlled by the water circulation within and across that interface. This study addresses the seasonal variation in water circulation, salinity pattern and the temporal seawater-freshwater exchange dynamics at the saltwater-wedge. This is achieved by linking geophysical exploration and numerical modeling to hydrochemical and hydraulic head observations from a lagoon site at the west coast of Denmark. The hydrochemical data from earlier studies suggests that increased inland recharge during winter drives a saltwater-wedge regression (seaward movement) whereas low recharge during summer causes a wedge transgression. Transient variable density model simulations reproduce only the hydraulic head dynamics in response to recharge dynamics, while the salinity distribution across the saltwater wedge cannot be reproduced with accuracy. A dynamic wedge is only simulated in the shallow part of the aquifer (<5 m), while the deeper parts are rather unaffected by fluctuations in freshwater inputs. Fluctuating salinity concentrations in the lagoon cause the development of a temporary intertidal salinity cell. This leads to a reversed density pattern in the underlying aquifer and the development of a freshwater containing discharge tube, which is confined by an overlying and underlying zone of saltwater. This process can explain observed trends in the in-situ data, despite an offset in absolute concentrations. Geophysical data indicates the presence of a deeper low hydraulic conductive unit, which coincides with the stagnant parts of the simulated saltwater-wedge. Thus, exchange fluxes refreshing the deeper low permeable areas are reduced. Consequently, this study suggests a very significant seasonal water circulation within the coastal aquifer near the seawater-freshwater interface, which is governed by the hydrogeological setting and the incoming freshwater fluxes, where nutrient delivery is limited to a small corridor of the shallow part of the aquifer.

Visual Field Reconstruction in Hemianopia Using fMRI Based Mapping Techniques

PurposeA stroke that includes the primary visual cortex unilaterally leads to a loss of visual field (VF) representation in the hemifield contralateral to the damage. While behavioral procedures for measuring the VF, such as perimetry, may indicate that a patient cannot see in a particular area, detailed psychophysical testing often detects the ability to perform detection or discrimination of visual stimuli (“blindsight”). The aim of this study was to determine whether functional magnetic resonance imaging (fMRI) could be used to determine whether perimetrically blind regions of the VF were still represented in VF maps reconstructed on the basis of visually evoked neural activity.MethodsThirteen patients with hemianopia and nine control participants were scanned using 3T MRI while presented with visual stimulation. Two runs of a dynamic “wedge and ring” mapping stimulus, totaling approximately 10 min, were performed while participants fixated centrally. Two different analysis approaches were taken: the conventional population receptive field (pRF) analysis and micro-probing (MP). The latter is a variant of the former that makes fewer assumptions when modeling the visually evoked neural activity. Both methods were used to reconstruct the VF by projecting modeled activity back onto the VF. Following a normalization step, these “coverage maps” can be compared to the VF sensitivity plots obtained using perimetry.ResultsWhile both fMRI-based approaches revealed regions of neural activity within the perimetrically “blind” sections of the VF, the MP approach uncovered more voxels in the lesioned hemisphere in which a modest degree of visual sensitivity was retained. Furthermore, MP-based analysis indicated that both early (V1/V2) and extrastriate visual areas contributed equally to the retained sensitivity in both patients and controls.ConclusionIn hemianopic patients, fMRI-based approaches for reconstructing the VF can pick up activity in perimetrically blind regions of the VF. Such regions of the VF may be particularly amenable for rehabilitation to regain visual function. Compared to conventional pRF modeling, MP reveals more voxels with retained visual sensitivity, suggesting it is a more sensitive approach for VF reconstruction.

Enhance dynamic wedge verification by using electronic portal imaging device

Objectives The purpose of this study was to verify the 80% enhanced dynamic wedge (EDW) beam profile using an electronic portal imaging device (EPID). Methods This study investigated symmetric and asymmetric field sizes using a 6 MV photon beam. Verification of the wedge output factor with an 80% beam profile was performed by comparing EPID measurements and treatment planning systems (TPS) calculations in both symmetric and asymmetric field sizes at different wedge angles (15, 30, 45, and 60 degrees). Results For the symmetric field size, the average difference between the measured and calculated beam profile was less than 2% (range 0.57-1.12%). For the asymmetric field size, the difference was also less than 2% (range 0.3-0.52%). Conclusion This study indicates that EPID can be used to verify the 80% enhanced dynamic wedge beam profile at different field sizes and wedge angles. The difference in beam profiles was less than 2% which is in accordance with AAPM TG no.142 recommendations.

Measurement of the photon and thermal neutron doses of contralateral breast surface in breast cancer radiotherapy

Introduction and purpose:During the radiation therapy of tumoral breast, the contralateral breast (CB) will receive scattered doses. In the present study, the photon and thermal neutron dose values received by CB surface during breast cancer radiation therapy were measured.Materials and methods:The right breast region of RANDO phantom was considered as CB, and the measurements of photon and thermal neutron dose values were carried out on this region surface. The phantom was irradiated with 18 MV photon beams, and the dose values were measured with thermoluminescent dosimeter (TLD-600 and TLD-700) chips for 11 × 13, 11 × 17 and 11 × 21 cm2 field sizes in the presence of physical and dynamic wedges.Results:The total dose values (photon + thermal neutron) received by the CB surface in the presence of physical wedge were 12·06%, 15·75% and 33·40% of the prescribed dose, respectively, for 11 × 13, 11 × 17 and 11 × 21 cm2 field sizes. The corresponding dose values for dynamic wedge were 9·18%, 12·92% and 29·26% of the prescribed dose, respectively. Moreover, the results showed that treatment field size and wedge type affect the received photon and thermal neutron doses at CB surface.Conclusion:According to our results, the total dose values received at CB surface during breast cancer radiotherapy with high-energy photon beams are remarkable. In addition, the dose values received at CB surface when using a physical wedge were greater than when using a dynamic wedge, especially for medial tangential fields.

Validação de Filtro Dinâmico em um acelerador linear Clinac 2100 CD

O filtro dinâmico otimizado (Enhanced Dynamic Wedge, EDW) utiliza o movimento do colimador para fazer o efeito de filtro, diminuindo o tempo de tratamento em relação ao filtro físico. Para validação do sistema foram feitas algumas comparações entre dados medidos e calculados pelo sistema de planejamento tais como: fluência de perfil de feixe; planos de tratamentos, utilizando a análise gama; Fator Filtro; e PDP. Os resultados da análise gama da comparação de fluência, tanto de perfil de feixe quanto para planos de tratamentos, foram entre 96% à 100% respectivamente, e, de Fator Filtro e PDP, a diferença máxima é de 1,9%. Assim os resultados se mostraram satisfatórios