Data reuse across international contexts? Reflections on new methods for International Qualitative Secondary Analysis

This research note reports on five online workshops by an international team of scholars, the authors, with shared interests in drug (mis)use. The workshops comprise a novel form of collective international qualitative secondary analysis (iQSA) exploring the possibilities for, and value of, qualitative data reuse across international contexts. These preparatory workshops comprise the preliminary stages of a longer programme of methodological development of iQSA, and we used them to identify what challenges there may be for translating evidence across international contexts, what strategies might be best placed to support or facilitate analytical engagement in this direction, and if possible, what empirical value such exchange might have. We discuss how working across international contexts involved the authors in new 'translational' work to address the challenges of establishing and sharing meaning. Such ‘translation’ entailed a modest degree of empirical engagement, namely, the casing of empirical examples from our datasets that supported an articulation of our various research studies, a collective interrogation of how, why and which such cases could be used for best translational effect and a collective reflexive engagement with how these cases generated new and novel questions that in turn re-engaged us with our own data in new ways. Descriptions of our datasets, therefore, emerged as multifaceted assemblages of ‘expertise’ and comprised the evidential bases for new empirical insights, research questions and directions.

Inequalities in the distribution of National Institutes of Health research project grant funding

Previous reports have described worsening inequalities of National Institutes of Health (NIH) funding. We analyzed Research Project Grant data through the end of Fiscal Year 2020, confirming worsening inequalities beginning at the time of the NIH budget doubling (1998-2003), while finding that trends in recent years have reversed for both investigators and institutions, but only to a modest degree. We also find that career-stage trends have stabilized, with equivalent proportions of early-, mid-, and late-career investigators funded from 2017 to 2020. The fraction of women among funded PIs continues to increase, but they are still not at parity. Analyses of funding inequalities show that inequalities for investigators, and to a lesser degree for institutions, have consistently been greater within groups (i.e., within groups by career stage, gender, race, and degree) than between groups.

Visual Field Reconstruction in Hemianopia Using fMRI Based Mapping Techniques

PurposeA stroke that includes the primary visual cortex unilaterally leads to a loss of visual field (VF) representation in the hemifield contralateral to the damage. While behavioral procedures for measuring the VF, such as perimetry, may indicate that a patient cannot see in a particular area, detailed psychophysical testing often detects the ability to perform detection or discrimination of visual stimuli (“blindsight”). The aim of this study was to determine whether functional magnetic resonance imaging (fMRI) could be used to determine whether perimetrically blind regions of the VF were still represented in VF maps reconstructed on the basis of visually evoked neural activity.MethodsThirteen patients with hemianopia and nine control participants were scanned using 3T MRI while presented with visual stimulation. Two runs of a dynamic “wedge and ring” mapping stimulus, totaling approximately 10 min, were performed while participants fixated centrally. Two different analysis approaches were taken: the conventional population receptive field (pRF) analysis and micro-probing (MP). The latter is a variant of the former that makes fewer assumptions when modeling the visually evoked neural activity. Both methods were used to reconstruct the VF by projecting modeled activity back onto the VF. Following a normalization step, these “coverage maps” can be compared to the VF sensitivity plots obtained using perimetry.ResultsWhile both fMRI-based approaches revealed regions of neural activity within the perimetrically “blind” sections of the VF, the MP approach uncovered more voxels in the lesioned hemisphere in which a modest degree of visual sensitivity was retained. Furthermore, MP-based analysis indicated that both early (V1/V2) and extrastriate visual areas contributed equally to the retained sensitivity in both patients and controls.ConclusionIn hemianopic patients, fMRI-based approaches for reconstructing the VF can pick up activity in perimetrically blind regions of the VF. Such regions of the VF may be particularly amenable for rehabilitation to regain visual function. Compared to conventional pRF modeling, MP reveals more voxels with retained visual sensitivity, suggesting it is a more sensitive approach for VF reconstruction.

Depth-dependent peridotite-melt interaction and the origin of variable silica in the cratonic mantle

Peridotites from the thick roots of Archaean cratons are known for their compositional diversity, whose origin remains debated. We report thermodynamic modelling results for reactions between peridotite and ascending mantle melts. Reaction between highly magnesian melt (komatiite) and peridotite leads to orthopyroxene crystallisation, yielding silica-rich harzburgite. By contrast, shallow basalt-peridotite reaction leads to olivine enrichment, producing magnesium-rich dunites that cannot be generated by simple melting. Komatiite is spatially and temporally associated with basalt within Archaean terranes indicating that modest-degree melting co-existed with advanced melting. We envisage a relatively cool mantle that experienced episodic hot upwellings, the two settings could have coexisted if roots of nascent cratons became locally strongly extended. Alternatively, deep refractory silica-rich residues could have been detached from shallower dunitic lithosphere prior to cratonic amalgamation. Regardless, the distinct Archaean melting-reaction environments collectively produced skewed and multi-modal olivine distributions in the cratonic lithosphere and bimodal mafic-ultramafic volcanism at surface.

‘The Fair Claims of Wales’

Nationalist unionism was not confined to Scotland. This chapter extends the book’s analysis to Wales, where the three unionist parties – Liberal, Labour and Conservative – had also deployed nationalist arguments and language in order to maintain Wales as part of the United Kingdom. As in Scotland, the originators of this approach were the Liberals, although one wing of the Labour Party in Wales was also nationalist in mindset as was, to a more modest degree, the Conservative Party, particularly in the 1950s and 2010s, when calculated appeals were made to Welsh traditions such as its distinct language. In contrast to Scotland after power was devolved in 1999, the Welsh Labour Party managed to maintain control of this ‘nationalist unionism’ while Plaid Cymru (which advocated greater autonomy) languished.

Diversity and Inclusion Practices in Nonprofit Associations: A Resource-Dependent and Institutional Analysis

Since the early 1990s, diversity and inclusion (D&I) efforts have received increasing attention among management scholars. Although the benefits and challenges of implementing D&I practices are now well established, few studies have explored the extent to which nonprofit associations, in particular, engage in D&I efforts. As such, we have no knowledge of the role that associations play in assisting with the diffusion of these practices throughout their respective professional fields or trades. Therefore, using a national survey of over 150 executives of nonprofit associations, this study explores the institutional and resource-based challenges associations face when seeking to implement D&I practices, both within their organizations and throughout their professional fields and trades. While the findings from this study suggest that nonprofit associations only engage in D&I practices to a modest degree, there is also evidence of institutional entrepreneurship. Implications of these findings for research on D&I practices in nonprofit associations as well as for association practitioners seeking to improve their D&I programming are provided.

New Algerian leader will struggle to restore stability

Significance Indeed, following a controversial vote on December 12, incoming President Abdelmadjid Tebboune faces a momentous challenge if he is to succeed in leading the country towards greater political and economic stability. Notably, he will need to break the current political impasse through a credible engagement with the protest movement. Interlinked with this is the need to demonstrate his independence from the military. Impacts If Tebboune makes credible concessions, opposition will fragment between those favouring dialogue and those preferring continued protest. Without Gaid Salah’s clear leadership, the military may be more divided and less able to set policy direction in the coming months. Tebboune’s initial government is likely to be dominated by unknown figures and may be weak, but will later try to co-opt opposition actors. Tebboune’s programme will probably support a modest degree of economic liberalisation.

What multiethnolects reveal about creole genesis

Recent theories of creole genesis propose that creole languages did not emerge via the expansion of pidgin varieties (DeGraff, 2001; Mufwene, 2001, 2008). This paper argues that the multiethnolects that have formed in many European cities constitute a demonstration case of the genesis scenario these new creolist theories reconstruct. Crucially, however, the multiethnolects, while displaying a modest degree of grammatical simplification and restructuring, exhibit this to nothing approaching the degree that creoles do. This supports the idea that creoles form from a break in transmission rather than simply hybridization.

A Major Limitation of the Direction of Causation Model: Non-Shared Environmental Confounding

Determining (1) the direction of causation and (2) the size of causal effects between two constructs is a central challenge of the scientific study of humans. In the early 1990s, researchers in behavioral genetics invented what was termed the direction of causation (DoC) model to address exactly these two concerns. The model claims that for any two traits whose mode of inheritance is sufficiently different, the direction of causation can be ascertained using a sufficiently large genetically informative sample. Using a series of simulation studies, we demonstrate a major challenge to the DoC model, namely that it is extremely sensitive to even tiny amounts of non-shared confounding. Even under ideal conditions for the DoC model (a large sample,N= 10,000), a large causal relationship (e.g., a causal correlation of .50) with very different modes of inheritance between the two traits (e.g., a pure AE model for one trait and a pure CE model for another trait) and a modest degree (correlation of .10) of non-shared confounding between the two traits results in the choice of the wrong causal models and estimating the wrong causal effects.

Provincial Differences in the Diagnosis and Care of Amyotrophic Lateral Sclerosis

Background: Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease resulting in muscle weakness, dysarthria and dysphagia, and ultimately respiratory failure leading to death. Half of the ALS patients survive less than 3 years, and 80% of the patients survive less than 5 years. Riluzole is the only approved medication in Canada with randomized controlled clinical trial evidence to slow the progression of ALS, albeit only to a modest degree. The Canadian Neuromuscular Disease Registry (CNDR) collects data on over 140 different neuromuscular diseases including ALS across ten academic institutions and 28 clinics including ten multidisciplinary ALS clinics. Methods: In this study, CNDR registry data were analyzed to examine potential differences in ALS care among provinces in time to diagnosis, riluzole and feeding tube use. Results: Significant differences were found among provinces, in time to diagnosis from symptom onset, in the use of riluzole and in feeding tube use. Conclusions: Future investigations should be undertaken to identify factors contributing to such differences, and to propose potential interventions to address the provincial differences reported.