Implementation of the optimal construction of a combination device and evaluation of reliability by output voltage

The theoretical propositions of the algebra of logic are considered. It is noted that the current microcircuitry based on the algebra of logic contains logical statements: true (yes) is a logical unit, false (no) is a logical zero. Based on the given logical function: ((ABC)×D + A×(BCD) + A×(BC)×D + (AB)×(CD), frontal, minimal, transformed minimal variants of the combination device are implemented, as well as minimized variants in the bases "AND-NOT" and "OR-NOT". A combination device based on import-substituting chips of 155, 176 series has been designed. The analysis of the obtained devices is made from the standpoint of technical and economic indicators, in particular, an assessment of the number of logic elements used, an assessment of the symmetry of the structure, as a result, a reduction in energy consumption, an increase in performance, improvements in parameters for reliability of functioning, a decrease in weight and size characteristics. Assuming that the law of change of the information parameter U1 is close to linear, taking into account the effect of temperature as boundary values for the elements of the applied microcircuits, taking the values -60 °C and +120°. Accordingly, the parametric reliability of the optimal implementation of the device according to the output voltage parameter is calculated. The conclusion is made about the inverse dependence of parametric reliability on temperature growth. A recommendation is given when evaluating parametric reliability for a number of other information parameters about the need to take into account both the number of chips used and the type of their interconnections.

Application of a BMP2-binding heparan sulphate to promote periodontal regeneration

Periodontitis is the most common inflammatory disease that leads to periodontal defects and tooth loss. Regeneration of alveolar bone and soft tissue in periodontal defects is highly desirable but remains challenging. A heparan sulphate variant (HS3) with enhanced affinity for bone morphogenetic protein-2 (BMP2) that, when combined with collagen or ceramic biomaterials, enhances bone tissue regeneration in the axial and cranial skeleton in several animal models was reported previously. In the current study, establishing the efficacy of a collagen/HS3 device for the regeneration of alveolar bone and the adjacent periodontal apparatus and related structures was sought. Collagen sponges loaded with phosphate-buffered saline, HS3, BMP2, or HS3 + BMP2 were implanted into surgically-created intra-bony periodontal defects in rat maxillae. At the 6 week end- point the maxillae were decalcified, and the extent of tissue regeneration determined by histomorphometrical analysis. The combination of collagen/HS3, collagen/BMP2 or collagen/HS3 + BMP2 resulted in a three to four-fold increase in bone regeneration and up to a 1.5 × improvement in functional ligament restoration compared to collagen alone. Moreover, the combination of collagen/HS3 + BMP2 improved the alveolar bone height and reduced the amount of epithelial growth in the apical direction. The implantation of a collagen/ HS3 combination device enhanced the regeneration of alveolar bone and associated periodontal tissues at amounts comparable to collagen in combination with the osteogenic factor BMP2. This study highlights the efficacy of a collagen/HS3 combination device for periodontal regeneration that warrants further development as a point-of-care treatment for periodontitis-related bone and soft tissue loss.

STITCHING TYPE LARGE APERTURE DEPOLARIZER FOR GAS MONITORING IMAGING SPECTROMETER

To increase the accuracy of radiation measurement for gas monitoring imaging spectrometer, it is necessary to achieve high levels of depolarization of the incoming beam. The preferred method in space instrument is to introduce the depolarizer into the optical system. It is a combination device of birefringence crystal wedges. Limited to the actual diameter of the crystal, the traditional depolarizer cannot be used in the large aperture imaging spectrometer (greater than 100 mm). In this paper, a stitching type depolarizer is presented. The design theory and numerical calculation model for dual babinet depolarizer were built. As required radiometric accuracies of the imaging spectrometer with 250 mm × 46 mm aperture, a stitching type dual babinet depolarizer was design in detail. Based on designing the optimum structural parmeters，the tolerance of wedge angle，refractive index, and central thickness were given. The analysis results show that the maximum residual polarization degree of output light from depolarizer is less than 2 %. The design requirements of polarization sensitivity is satisfied.