Combined Low-Level Light Therapy and Intense Pulsed Light Therapy for the Treatment of Dry Eye in Patients with Sjögren’s Syndrome

Purpose. To evaluate the effects of combined intense pulsed light therapy (IPL) and low-level light therapy (LLLT) in dry eye disease (DED) in patients affected by Sjögren’s syndrome. Patients and Methods. This is a monocentric, prospective, interventional study. At baseline, all the study patients (n = 20) were on tear substitute therapy and underwent Schirmer type-1 test and breakup time (BUT) test. After baseline measurements, tear substitute therapy was suspended, and patients underwent IPL and LLLT. The same investigations were carried out at one (T1) and at three (T3) months after treatment. The Ocular Surface Disease Index (OSDI) survey was used to measure the severity of DED. Results. BUT test showed an increase in tear film breakup time in patients with DED 1 month after the beginning of the treatment (T0 vs T1: p = 0,01 ). This increase was even more statistically significant after 3 months of the IPL and LLLT treatment (T0 vs T3: p < 0.0001 ). Schirmer test values increased too, but there was not statistically significance between values at T0 and T1 or T3. The patients perceived an improvement in their condition, which resulted in a lower score on the OSDI survey. The OSDI score was lower at T1 than T0 (T0 vs T1: p = 0.0003 ), while it tended to increase again after 3 months although it was still lower than baseline (T0 vs T3: p = 0.02 ). No facial or ocular side effects were reported. Conclusions. The use of combined IPL/LLLT for the treatment of DED in patients affected by Sjögren’s syndrome appears to be beneficial.

Effect of the medicine “Cationorm” on lacrimal film in obstructive dysfunction of meibomyus glands among users of soft contact lenses

There are more than 80 million users of soft contact lenses in the world - 10-15 % of the population. The prevalence of meibomyus gland dysfunction is 43-61 % with the prevalence of obstructive form and the development of lipodeficiency in lacrimal film. At the same time, the use of traditional tear substitutes based on hyaluronic acid is ineffective and the problem of finding a tear substitute with exposure to all 3 layers of lacrimal film becomes relevant. Nanoemulsion “Cationorm” is created as a means of pathogenetic therapy of dry eye syndrome against the background of lipodeficiency, however, there weren't any studies of its effectiveness in obstructive form of meibomyus gland dysfunction among users of soft contact lenses. We examined 3 layers of lacrimal film with the help of Norn's sample with determination of time of lacrimal film break, bio-measurement of lacrimal meniscus and biomicoscopy of eyelid edge region at painting of lissamino-om green. The study involved 28 young carriers of silicone-hydrogel contact lenses with signs of obstructive form of meibomyus gland dysfunction, who we divided into two groups: a control group used to eliminate the symptoms of a hyaluronic acid-based tear substitute, and an experimental group using the drug “Cationorm”. We revealed prolonged effect of nanoemulsion “Cationorm” on all three layers of lacrimal film, which hasn't only symptom lacrimal, but has pathogenetic therapeutic delayed effect among users of soft contact lenses with obstructive form of dysfunction of meibomyum glands, and nanostimer of lipid microspheres provides full compatibility even with material of silicone-hydrogel soft contact lenses. We proved the protective effect of the preparation on ocular epithelium cells.

Ayurvedic Management of Dry Eye Sydrome - A Case Study

Dry eye syndrome is a common condition that results from reduced tear production or excessive tear evaporation or an abnormality in the production of mucus or lipids normally found in the tear layer or combination of these. If blinking is decreased or if the eyelids cannot be closed, they may dry out leading to dry eye. It is accompanied by increased osmolarity of the tear film and inflammation on the surface of the eye may occur of left untreated leading to pain, ulcers or scars on the cornea and loss of vision. Prevalence of dry eye range from 5% to 35% worldwide while in India it is 29.25%. Tear substitute are the only treatment modality with modern medicine, only providing symptomatic relief. Ayurveda describes similar condition called Sushkakshi Paka and this patient was treated with Tarpana and Nasya with Jeevantyadi Ghrita.

The evolution of tear substitutes: from saline solutions to cationic nanoemulsion

The article defines the milestones of the development of the main types of artificial tears, describes characteristics and benefits of the new tear substitute Cationorm® based on Novasorb® technology: electrostatic mucoadhesion, rapid and optimal spreading, and long time of contact with the ocular surface, favorable action on all tear film layers, osmoregulation, compatibility with different contact lens types, and prolonged clinical efficacy.