Identification of G protein-coupled receptor 55 (GPR55) as a target of curcumin

The identification of molecular targets of bioactive food components is important to understand the mechanistic aspect of their physiological functions. Here, we have developed a screening system that enables us to determine the activation of G protein-coupled receptors (GPCRs) by food components and have identified GPR55 as a target for curcumin. Curcumin activated GPR55 and induced serum-response element- and serum-response factor-mediated transcription, which were inhibited by Rho kinase and GPR55 antagonists. Both the methoxy group and the heptadienone moiety of curcumin were required for GPR55 activation. The F1905.47 residue of GPR55 was important for the interaction with curcumin. The curcumin-induced secretion of glucagon-like peptide-1 in GLUTag cells was inhibited by a GPR55 antagonist. These results indicate that expression screening is a useful system to identify GPCRs as targets of food components and strongly suggest that curcumin activates GPR55 as an agonist, which is involved in the physiological function of curcumin.

The Effect of a Similar Strategy in The Rebuilding of Valuable Buildings

Reconstruction of archaeological buildings with destroyed or collapsed parts is considered oneof the most important and accurate operations in the field of preserving those buildings, given the continuityof these operations in the continuity of those archaeological buildings with their architectural and technicaldetails, and even their continued performance in their urban environment in many cases. These operationsare concerned with missing parts or the replacement of damaged parts. Many studies emerged that dealtwith this important aspect of reconfiguring and completing the demolished parts in historical and heritagebuildings, whether at the level of the part or all according to specific laws, but no study of the formal andintellectual mechanisms used to rebuild and reconstruct these buildings and their potential for architecturalproductions. Therefore, the research problem that emerged from the lack of clarity of knowledge about themost important formal and intellectual mechanisms for rebuilding in architecture and its cognitive indicatorswithin the outcome emerged, and the research was divided into two parts, the first part represented by thegeneral theoretical presentation that included the reconstruction processes and related determinants andclarification of the mechanism of formalism (similar and its connections) Theory and intellectual mechanism(analogy and its theoretical correlations), previous studies and the second part which represented the appliedside to form the theoretical framework from the above and applied it to groups of architectural productionsand then presented and discussed and analyzed the results of that application up to the presentation ofCrowns and recommendations that were referring to the general vision of the basic concept of researchadopted, the mechanistic aspect of form rather than intellectual.

Carbon nanotubes for rapid capturing of SARS-COV-2 virus: revealing a mechanistic aspect of binding based on computational studies

Investigation of the binding interactions of synthesized multi-walled carbon nanotubes (MWCNTs) with SARS-CoV-2 virus.

Vanadium-Substituted Phosphomolybdic Acids for the Aerobic Cleavage of Lignin Models—Mechanistic Aspect and Extension to Lignin

This work deals with the aerobic oxidative cleavage of C-C and C-O bonds catalyzed by the Keggin-type phosphovanadomolybdic acid (H6[PMo9V3O40], noted H6PV3). The latter was synthesized by an adapted hydrothermal procedure classically used for lower vanadium content and was tested as a catalyst for the aerobic cleavage of 2-phenoxyacetophenone (noted K1HH) and 1-phenyl-2-phenoxyethanol (A1HH) used as two lignin models. The operative conditions (solvent, catalytic loading, etc.) were adjusted on K1HH and extrapolated to A1HH. The cleavage of the alcohol model required more drastic conditions and therefore further optimization. Preliminary attempts on an Organosolv wheat straw lignin were performed too. From the kinetic study, high performance liquid chromatography (HPLC) and gas chromatography–mass spectrometry (GC-MS) data, a mechanism of the cleavage of both models was proposed.