Chlamydia pecorum Ovine Abortion: Associations between Maternal Infection and Perinatal Mortality

Chlamydia pecorum is a common gastrointestinal inhabitant of livestock but infections can manifest in a broad array of clinical presentations and in a range of host species. While C. pecorum is a known cause of ovine abortion, clinical cases have only recently been described in detail. Here, the prevalence and sequence types (STs) of C. pecorum in ewes from a property experiencing high levels of perinatal mortality (PNM) in New South Wales (NSW), Australia, were investigated using serological and molecular methods. Ewes that were PNM+ were statistically more likely to test seropositive compared to PNM− ewes and displayed higher antibody titres; however, an increase in chlamydial shedding from either the rectum, vagina or conjunctiva of PNM+ ewes was not observed. Multilocus sequence typing (MLST) indicated that C. pecorum ST23 was the major ST shed by ewes in the flock, was the only ST identified from the vaginal site, and was the same ST detected within aborted foetal tissues. Whole genome sequencing of C. pecorum isolated from one abortion case revealed that the C. pecorum plasmid (pCpec) contained a unique deletion in coding sequence 1 (CDS1) that was also present in C. pecorum ST23 shed from the ewes. A further unique deletion was noted in a polymorphic membrane protein gene (pmpG) of the C. pecorum chromosome, which warrants further investigation given the role of PmpG in host cell adherence and tissue tropism.This study describes novel infection parameters in a sheep flock experiencing C. pecorum-associated perinatal mortality, provides the first genomic data from an abortigenic C. pecorum strain, and raises questions about possible links between unique genetic features of this strain and C. pecorum abortion.

Ethics and Legal Issues in the Abortion Case

In Indonesia regulated in Law No. 36 of 2009 on health. Any person who deliberately performs an abortion is inconsistent with the provisions referred to in Article 75 paragraph (2) shall be punished with imprisonment of not more than 10 (ten) years and a maximum fine of Rp.1.000.000.000,00 (one billion rupiah). Basically, the treatment of abortion is found in them in life. Some of the driving forces for abortion are quite numerous and the abortion treatment can be viewed in any perspective. One thing that is commonplace among today is such an unwanted pregnancy because of a factor and aims to disrupt the pregnancy by an act of abortion. But the act of abortion is not roughly done deliberately but the existence of an unwanted so that the act of abortion should be done. The notion of abortion of the womb, the fetal exclusion is not appropriate in time whether it is intentional or not.

COMPARATIVE STUDY OF SUBLINGUAL AND VAGINAL MISOPROSTOL TABLET IN MISSED ABORTION

Introduction: Management of missed abortion is matter of concern for obstetrician in terms of its methods and complications. Objectives: To compare efficacy, side effects and complications of sublingual and vaginal misoprostol tablet in missed abortion case of less than 20 weeks of gestation. Methods: Total 300 cases were taken, and out of those 300 cases, group A (150cases) included cases who were given sublingual misoprostol tablet, and group B (150 cases) included cases who were given vaginally misoprostol tablet. Observation: Mean gestational age is 7.9 and 8 weeks in Group A and Group B respectively. P value is 0.94. (Not significant). Mean induction abortion interval is 11.6 hours and 12.9 hours in Group A and Group B respectively i.e., the induction abortion interval is slightly short in the Group A. P value is 0.9, means the difference is not statistically significant. Mean dose of misoprostol was 1004.6 microgm and 1080 microgm for group A and group B respectively. P value is 0.029 is significant. Incidence of side effects (nausea, vomiting, unpleasant taste) was higher in group A than group B. P value is <0.05 is significant. Success rate was 86% in group A and 80% in group B. Conclusion: Sublingual and vaginal misoprostol tablet are both equally effective for medical management of missed abortion. Mean dose required for abortion is more in vaginal misoprostol but side-effects are more associated with sublingual misoprostol tablets.

US Supreme Court will hear a contentious abortion case

Headline UNITED STATES: Supreme Court will hear abortion case

HUBUNGAN KARAKTERISTIK IBU DENGAN KEJADIAN ABORTUS DI RSU MUHAMMADIYAH MEDAN TAHUN 2020

According to the World Health Organization (WHO), 15-50% of maternal deaths are caused by abortion. Data shows the possibility of a fairly high percentage, approximately 15-40% the number of known occurrences on mothers who already stated positively pregnant, and 60-75% of abortion occurs before the pregnancy reaches 12 weeks. This research investigates the relationship between the mother’s characteristics with the abortion case in the RSU Muhammadiyah. The investigation was conducted in a cross-sectional analysis. The population is 42 mothers who experienced abortion in the RSU Muhammadiyah based on medical record year 2020. Statistical analysis using chi-square with the p-value of age, parity, and education parameters are 0,002, 0.017, and 0.004 respectively. This data showed that there was a relationship between age, parity, and education with abortion cases in RSU Muhammadiyah Medan. This report might be useful for the government and stakeholders in controlling the abortion case in Medan.

Pregnancy in a Patient With Mosaic Turner Syndrome: A Case Report

Turner Syndrome (TS) is a chromosomal sex disorder, phenotypically characterized by short stature, webbed neck, cubitus valgus, and rarely with slight intellectual disability. A majorityof TS patients (95%-98%) have infertility due to ovarian failure. Pregnancy in TS patients is an unusual case; however, pregnancy could rarely occur in mosaicism TS patients withoutany assistance. Pregnancy in such patients is associated with high risks of maternal mortality, spontaneous abortion, as well as the congenital and karyotype abnormalities of the fetus. A30-year-old pregnant woman has referred to our genetics lab with a history of polyabortivity. Her menarche occurred at the age of 13 years and her menstruation was claimed to be in aregular cycle. The patient’s two first pregnancies resulted in stillbirth, whereas the third one was delivered through caesarian surgery, but spoiled after 8 days. Our case was characterizedby mosaicism 45, X/45, XX, after referring as a multi-abortion case. The fourth pregnancy has happened at the age of 31 years and a healthy embryo with normal heart function wasdiagnosed by sonography in 17 weeks of gestation. The result of amniocentesis confirmed a healthy female embryo with 46, XX karyotype. Spontaneous pregnancy is regarded as aprecarious situation terrifying by abortion or malignancy; also, chromosomal abnormalities, like trisomy 21 and TS, are prevalent in offspring. Therefore, it is strongly recommended tohave cohort studies based on karyotype characterization to decrease the patient’s concerns as well as to follow more practical clinical approaches.

CASE REPORT: NASOPHARYNGEAL CARCINOMA IN PREGNANCY

Introduction: Nasopharyngeal carcinoma in pregnancy is a rare case, a dilemma in its management. This condition has a significant negative effect on pregnancy, given risk of premature birth, fetal defects and abortion. Case Report: 23-year-old woman with 13 weeks gestation age comes with swelling in both necks accompanied by nosebleeds. On nasoendoscopic examination, there was a mass at nasopharynx. Histopathological examination results a nasopharyngeal squamous cell carcinoma. Conclusion: The management of nasopharyngeal carcinoma in pregnancy is very complex, need for extensive multidisciplinary approach with experienced doctors in their respective fields