Side effects of drugs studied on ant models: a mini review

Using ants as models, we studied until now the side effects of 47 products used by humans and, over these studies we published five summaries of our main findings. After that, we studied the side effects of six other drugs used by humans, and we here summarize these lastly obtained results. These six other drugs were dextromethorphan, amitriptylin, escitalopram, fluvoxamine, iverectin, and indapamide. For each of them, we found side effects similar to those reported for humans, but we also observed side effects not yet mentioned for humans. They concerned among others the locomotion, the activity, the sensory perception, the social relationships and the learning. Practitioners and pharmacists should take cognizance of our works for more adequately and safely used the six drugs we examined. Our six works are published and thus available, but they can also be provided by the author(s). All over our studies, ants appeared to be excellent biological models; the experiments could be made easily, rapidly and at lost cost, while providing statistically significant results.

Modulation of sensory perception by hydrogen peroxide enables Caenorhabditis elegans to find a niche that provides both food and protection from hydrogen peroxide

Hydrogen peroxide (H2O2) is the most common chemical threat that organisms face. Here, we show that H2O2 alters the bacterial food preference of Caenorhabditis elegans, enabling the nematodes to find a safe environment with food. H2O2 induces the nematodes to leave food patches of laboratory and microbiome bacteria when those bacterial communities have insufficient H2O2-degrading capacity. The nematode’s behavior is directed by H2O2-sensing neurons that promote escape from H2O2 and by bacteria-sensing neurons that promote attraction to bacteria. However, the input for H2O2-sensing neurons is removed by bacterial H2O2-degrading enzymes and the bacteria-sensing neurons’ perception of bacteria is prevented by H2O2. The resulting cross-attenuation provides a general mechanism that ensures the nematode’s behavior is faithful to the lethal threat of hydrogen peroxide, increasing the nematode’s chances of finding a niche that provides both food and protection from hydrogen peroxide.

On Dependency between Wishes and Perception

Introduction. Empirical studies of recent years convincingly show that the character of sensory perception can be influenced by non-cognitive mental states of the agent, such as her desires. The aim of the paper is to analyze how this causal connection between agent's wishes and her sensations can affect the epistemological status of dependent sensations.Methodology and sources. The author examines S. Siegel's argument on this issue. S. Siegel argues that the empirically proven dependence of sensations on desires (wishful seeing) should lead to a decrease of the epistemological status of sensations to the same extent as the dependence of beliefs on desires (wishful thinking) leads to a decrease of the epistemological status of these beliefs. Thus Siegel's argument concludes that the phenomenon of wishful seeing deprives us of any reason to accept sensations as credible evidence of the states of the world. So, this is an argument in favor of skepticism.Results and discussion. The article discusses two main strategies for rejecting Siegel's argument. According to the first strategy proposed by R. Long, sensations are not so similar to beliefs that one can conclude that their epistemological status should be decreased on the basis of their dependence on desires. According to another strategy for refuting Siegel's argument, proposed by A. Raftopoulos, the influence of desires on perception does not extend to early vision. Early vision is free from the influence of higher order conscious mental states. The dependence of the results of sensory perception on other mental states is reduced to the influence of these states on the agent's attention. At the same time, attention can be volitionally controlled and can be trained. Therefore dependent perception under certain conditions can be rationally accepted.Conclusion. Thus, the article shows that, even though perception is dependent on other non-cognitive mental states, such as desires, this dependence does not necessarily lead to a decrease in the epistemological status of sensations, so sensations can be rationally accepted under certain conditions. This means that Siegel's argument for skepticism is not compelling.

Consumer Perception of Milk and Plant-Based Alternatives Added to Coffee

Consumers have begun to use plant-based alternatives (PBAs) in their coffee instead of dairy products. PBAs can include soy milk, rice milk, coconut milk, almond milk, oat milk, and hemp milk. The objective of this study was to investigate consumer acceptability and sensory perception of coffee with added dairy milk and added oat, soy, and almond PBAs. Consumers (n = 116) that frequently add milk to their coffee (n= 58) and consumers that usually use PBAs (n = 58) were recruited to participate in the study. They evaluated four different coffee samples with the addition of dairy milk as well as soy, almond, and oat PBAs. Overall, the consumers liking increased when they perceived sweetness in their coffee. The plant consumers (usually added PBAs to their coffee) liked the milk addition significantly less than the dairy consumers (usually added dairy to their coffee). In addition, the plant consumers were able to differentiate between the almond and soy PBAs, while the dairy consumers grouped them together. More studies need to be completed to investigate a wider range of PBAs, dairy products, and varieties of coffee.