This study examines the potential contribution of the Baku-Tbilisi-Kars (BTK) railway, which is planned to be in service in 2017, to the commercial relationship between Turkey and five Turkish republics (Azerbaijan, Kazakhstan, Uzbekistan, Kyrgyzstan and Turkmenistan). First, the general structure of the last five years of foreign trade between Turkey and these states will be revealed. In the second stage, transport routes which are used extensively in the physical transport of goods in the current trade, and the benefits and drawbacks of these routes will be mentioned. In the third stage, the characteristics of the BTK railway will be specified as a new route option. In the last part, the future contribution of the BTK railway to the trade between Turkey and these states will be evaluated.