RELATONSHIP BETWEEN SERUM LIPOPROTEIN-ASSOCIATED PHOSPHOLIPSAE A2 AND CAROTD INTMAMEDIA THICKNESS WITH CEREBRAL INFARCTON

Background and Purpose: Cerebral atherosclerosis is the leading cause of mechanical obstruction of blood flow that final event is cerebral infarction. Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an inflammatory biomarkers specific for blood vessels, is an important factor predicted extent of atherosclerosis. The study aimed to assess the association between serum Lp-PLA2 concentration with carotid intimamedia thickness (IMT). Materials andMethod: The cross – sectional study, in 37 patients who presented to Department of Cardiology - Hue University Hospital and Hue Central Hospital. Vulnerability asessment of the external carotid artery into the skull through ultrasound by measuring carotid intima-media thickness. Testing serum Lp-PLA2 concentration, lipid profile, blood glucose. Results: Group of patients with thickness of carotid IMT levels of serum Lp-PLA2 was 27.73 IU/ml higher than the group with thickness normal carotid IMT was 14.35 IU/ml; p < 0.05. Total cholesterol, LDL cholestrol, triglycerid and Lp-PLA2 are the factors capable of predict the changes in size IMT; (p <0.05). There is moderate correlation between Lp-PLA2 levels and carotid intima-media thickness (r = 0.47; p < 0.05). Conclusion: Higher Lp-PLA2 levels is significantly associated with carotid intimamedia thickness in patients who have cerebral infarction. Key words: Stroke, atherosclerosis, inflammation, biomarker.

The Effect of Structured Exercise Classes and a Lifestyle Intervention on Cardiovascular Risk Factors in Primary Schoolchildren: An Exploratory Trial (The A-CLASS Project)

This exploratory trial evaluates the effect of a structured exercise (STEX) or lifestyle intervention (PASS) program upon cardiovascular (CV) disease risk factors in children. Sixty-one schoolchildren were randomly assigned by school to an intervention or control (CON) condition. The effect of the STEX (compared with CON) was a mean benefit of −0.018 mm for average maximum carotid intimamedia thickness. The PASS intervention did not result in clinically important effects, and no other substantial changes were observed. Relatively high probability of clinically beneficial effects of the STEX intervention suggests that a larger, definitive randomized trial with longer follow-up is warranted.