Acquisition of Swept Aerodynamic Data by the Consecutive Changing of Wing Model Configuration in a Wind Tunnel Test Using Remote Feedback Control

This study conducted wind tunnel tests with consecutive deflection angle changes on a three-dimensional (3D) wing with a control surface to procure aerodynamic data by sweeping the deflection angle. Configuration changes of a wind tunnel test model, such as changing the deflection angle of control surfaces, are usually performed manually with the ventilation suspended. Hence, the number of configurations that can be implemented within a confined test period is restricted; the aerodynamic data gained are discrete values. To accomplish continuous angular modulation would dramatically improve the ability by sweeping through the aerodynamic data in wind tunnel tests, enhancing the test system as a tool for discussing complex physical phenomena. Thus, this study created a compact remote feedback control system using optical measurement to continuously obtain high-precision aerodynamic data without stopping the wind tunnel, eliminating human operation. In particular, this study targets a 3D wing wind tunnel model with a control surface, which is more challenging to fabricate, miniaturizing the system in a model. The system consequently attained consecutive aerodynamic data multiple times under numerous configurations, which had been impracticable to reach in the past, within a wind tunnel test period of several days, thereby dramatically increasing the testing capability. The reproducibility was quantitatively verified by comparing the multiple data for the identical configurations. Furthermore, the reliability was demonstrated using discrete data obtained by conventional stepwise deflection angle adjustments. Eventually, the system was able to grasp physical phenomena involving hysteresis.

A systematic review of the effects of remote feedback in home-based strategy physical activity interventions for cancer survivors

Background: Studies have reported on positive health outcomes from physical activity (PA) for cancer survivorship. Systematic reviews, meta-analysis and trial studies have concluded that PA intervention improves quality of life and physical function, reduces the relapse of cancer and mitigates cancer mortality. Despite these important gains, cancer survivors’ PA level is still not satisfactory. Across all cancer types, home is the most preferred location of PA. This study aims to evaluate the effectiveness of remote feedback delivery strategy for home-based PA among cancer survivors. Methods: A systematic review was conducted by retrieving relevant articles published from the year 2009 to 2019 from the database aggregator EBSCOhost (databases used were Medline, CINAHL, SPORT Discuss and Cochrane trials). Results: Both frequent remote contact and direct remote contact are equally effective and have a larger effect than programmes with usual care, no intervention, participants placed in waiting list for intervention or participants given basic guidelines on PA. Direct remote contact reported strong evidence of moderate effect while frequent telephone contact reported conflicting findings of varied effect sizes. Conclusion: Opting for remote feedback strategies with supervised exercise provide an easier approach for the cancer survivors to keep up with exercise for a longer period of time and can be integrated in a cancer survivor’s lifestyle.

Conformational Plasticity of the Active Site Entrance in E. coli Aspartate Transcarbamoylase and Its Implication in Feedback Regulation

Aspartate transcarbamoylase (ATCase) has been studied for decades and Escherichia coli ATCase is referred as a “textbook example” for both feedback regulation and cooperativity. However, several critical questions about the catalytic and regulatory mechanisms of E. coli ATCase remain unanswered, especially about its remote feedback regulation. Herein, we determined a structure of E. coli ATCase in which a key residue located (Arg167) at the entrance of the active site adopted an uncommon open conformation, representing the first wild-type apo-form E. coli ATCase holoenzyme that features this state. Based on the structure and our results of enzymatic characterization, as well as molecular dynamic simulations, we provide new insights into the feedback regulation of E. coli ATCase. We speculate that the binding of pyrimidines or purines would affect the hydrogen bond network at the interface of the catalytic and regulatory subunit, which would further influence the stability of the open conformation of Arg167 and the enzymatic activity of ATCase. Our results not only revealed the importance of the previously unappreciated open conformation of Arg167 in the active site, but also helped to provide rationalization for the mechanism of the remote feedback regulation of ATCase.

Translating Behavior Change Principles Into a Blended Exercise Intervention for Older Adults: Design Study (Preprint)

BACKGROUND Physical activity can prevent or delay age-related impairments and prolong the ability of older adults to live independently. Community-based programs typically offer classes where older adults can exercise only once a week under the guidance of an instructor. The health benefits of such programs vary. Exercise frequency and the duration of the program play a key role in realizing effectiveness. An auxiliary home-based exercise program can provide older adults the opportunity to exercise more regularly over a prolonged period of time in the convenience of their own homes. Furthermore, mobile electronic devices can be used to motivate and remotely guide older adults to exercise in a safe manner. Such a blended intervention, where technology is combined with personal guidance, needs to incorporate behavior change principles to ensure effectiveness. OBJECTIVE The aim of this study was to identify theory-based components of a blended intervention that supports older adults to exercise at home. METHODS The Medical Research Council framework was used to develop the blended intervention. Insights from focus group, expert panels, and literature were combined into leading design considerations. RESULTS A client-server system had been developed that combined a tablet app with a database in the cloud and a Web-based dashboard that can be used by a personal coach to remotely monitor and guide older adults. The app contains several components that facilitate behavior change—an interactive module for goal setting, the ability to draw up a personal training schedule from a library containing over 50 exercise videos, progress monitoring, and possibilities to receive remote feedback and guidance of a personal coach. CONCLUSIONS An evidence-based blended intervention was designed to promote physical activity among older adults. The underlying design choices were underpinned by behavior change techniques that are rooted in self-regulation. Key components of the tablet-supported intervention were a tailored program that accommodates individual needs, demonstrations of functional exercises, monitoring, and remote feedback. The blended approach combines the convenience of a home-based exercise program for older adults with the strengths of mobile health and personal guidance.

Effectiveness of remote feedback on physical activity in persons with type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials

Objectives The objective of this systematic review and meta-analysis was to examine the effectiveness of remote feedback intervention compared with standardized treatment on physical activity levels in persons with type 2 diabetes. Further, to investigate the influence of the length of intervention, number of contacts, study size, delivery of feedback, and preliminary face-to-face sessions. Methods A systematic literature search was conducted in May 2017, with a priori defined eligibility criteria: randomized controlled trials investigating remote feedback interventions in adult persons with type 2 diabetes, using physical activity as outcome. The effect size was calculated as standardized mean difference (SMD) and was pooled in a meta-analysis using a random-effects model. Meta-regression analyses were performed to examine if the observed effect size could be attributed to study- or intervention characteristics using these as covariates. Results The literature search identified 4455 articles of which 27 met the eligibility criteria. The meta-analysis including a total of 4215 participants found an overall effect size in favour of remote feedback interventions compared to standardized treatment, SMD = 0.33 (95% CI: 0.17 to 0.49), I2 = 81.7%). Analyses on study characteristics found that the effect on physical activity was only influenced by study size, with a larger effect in small studies. Conclusion Adding remote feedback to standardized treatments aimed at increasing physical activity in persons with type 2 diabetes showed a small to moderate additional increase in physical activity levels. Systematic review registration: PROSPERO CRD42016033479.