Active single cell encapsulation using SAW overcoming the limitations of Poisson distribution

We demonstrate the use of an acoustic device to actively encapsulate single red blood cells into individual droplets in a T-junction. We compare the active encapsulation with the passive encapsulation...

Acoustic manipulation of fractal metamaterials with negative properties and near-zero densities

Acoustic metamaterials have high potential in diverse applications, including acoustic cloaking, sound tunneling, wavefront reshaping, and sound insulation. In the present study, new metamaterials consisting of spatial coiled units are designed and fabricated to manipulate sound waves in the range 0-1600 Hz. The effective acoustic properties and band diagrams are studied. The simulation and experimental results demonstrate that the metamaterials provide an effective and feasible approach to design acoustic device such as sound cloaking and insulators.

Noise-Making, Occupy Wall Street, and the Politics of Amplification

This research explores a set of sound technologies deployed during the 2011 Occupy Wall Street protests in New York City’s Zuccotti Park. It examines the People’s Microphone, the Long Range Acoustic Device (LRAD) sound cannon, the drum circle, and the noise complaint. Deepening understandings of their places within the contemporary urban soundscape and their use during the protests, it uses historical research, textual analysis, and qualitative discourse analysis methods to explore the technologies within a larger framework of the city’s discourses around (in)appropriate sound and action. Its findings suggest that each individual technology was evidence for the nature of its user in a way that presaged how the conflict would play out. The microphone epitomized the ideology (and fragility) of the hyper-democratic Occupiers’ ethos. The LRAD suggested the state’s superlative sonic capability and its “monopoly on the legitimate use of noise.” And the drum circles and noise complaints that followed ultimately showed the ways “noise-making” is better understood as a discursive construction that delegitimizes sound. Together, they suggest the ways the hegemonic soundscape serves the status quo. The essay also elaborates a taxonomy of sonic terms, specifically exploring volume, amplification, and noise-making as terms that explain the dynamics of sound during protest. It offers scholars of media activism a toolkit for sound studies that gets at the dynamics and structures of sonic power and explores the way sound-making is a key battleground of modernity. Sound conventions are a way that contemporary society is codified, legislated, and contested.

Cost-effectiveness of adding a non-invasive acoustic rule-out test in the evaluation of patients with suspected stable angina pectoris. Design of the randomized multicenter FILTER-SCAD trial

Background Patients with suspected stable coronary artery disease (CAD) are selected for further non-invasive or invasive diagnostic tests depending on their pre-test probability (PTP) of obstructive CAD. However, the PTP, based on age, sex, and type of angina, has shown to grossly overestimate the likelihood of obstructive CAD. Consequently, the use of diagnostic tests has increased over the last decades despite a low diagnostic yield (6–7%). The CAD-score is a risk stratification score for obstructive CAD measured using a novel non-invasive acoustic device, and when added to PTP has shown excellent rule-out capabilities. Purpose To investigate if the addition of the CAD-score to a standard diagnostic examination is superior in terms of reducing overall number of diagnostic procedures and non-inferior in terms of safety as compared to a standard PTP-guided strategy when evaluating patients with suspected stable CAD. Methods The FILTER-SCAD trial is a randomized, controlled, multicenter trial expected to include 2000 subjects ≥30 years of age without known CAD referred for outpatient assessment for suspected CAD at 5 hospitals in Denmark and Sweden. First subject was randomized on October 22, 2019. Subjects will be randomized 1:1 to either 1) a control group undergoing standard diagnostic examination (SDE) according to current guidelines, or 2) an intervention group undergoing SDE plus a CAD-score measurement, using permuted block randomization stratified by study site and PTP (very low vs. low-intermediate). Follow-up will be 12 months for a primary endpoint of cumulative number of diagnostic tests and a combined secondary safety endpoint of all-cause death, non-fatal myocardial infarction, unstable angina pectoris, heart failure, and ischemic stroke. Questionnaires assessing symptom severity, quality of life, life style measures, and medical treatment will be collected at baseline, 3 months, and 12 months after randomization. The study is powered to detect superiority in terms of cumulative number of diagnostic tests with a power of 80% and a significance level of 0.05, and non-inferiority on the safety endpoint with a power of 90% and a significance level of 0.05. The study is conducted in compliance to the principles of the Declaration of Helsinki of the World Medical Association. ClinicalTrials.gov ID: NCT04121949. Results One study site is currently enrolling. Preliminary baseline data is available on the first 77 (44% males) enrolled patients (median age 61 years IQR (51–72) and PTP 22% IQR (13–38)) showing successful randomization with even distribution of baseline characteristic between the two groups including sex, age, and PTP. Perspectives The FILTER-SCAD trial will investigate whether it is feasible to reduce resource consumption without compromising safety in the outpatient assessment of patients with suspected CAD using a simple, non-invasive acoustic device. Enrollment and follow-up are expected to be completed spring 2022. Funding Acknowledgement Type of funding source: Other. Main funding source(s): The company Acarix A/S har provided an unrestricted grant for the study. The Foundation “Fonden for Faglig Udvikling i Speciallægepraksis” has provided a grant for the study.