Multifunctional Enkephalin Analogs with a New Biological Profile: MOR/DOR Agonism and KOR Antagonism

In our previous studies, we developed a series of mixed MOR/DOR agonists that are enkephalin-like tetrapeptide analogs with an N-phenyl-N-piperidin-4-ylpropionamide (Ppp) moiety at the C-terminus. Further SAR study on the analogs, initiated by the findings from off-target screening, resulted in the discovery of LYS744 (6, Dmt-DNle-Gly-Phe(p-Cl)-Ppp), a multifunctional ligand with MOR/DOR agonist and KOR antagonist activity (GTPγS assay: IC50 = 52 nM, Imax = 122% cf. IC50 = 59 nM, Imax = 100% for naloxone) with nanomolar range of binding affinity (Ki = 1.3 nM cf. Ki = 2.4 nM for salvinorin A). Based on its unique biological profile, 6 is considered to possess high therapeutic potential for the treatment of chronic pain by modulating pathological KOR activation while retaining analgesic efficacy attributed to its MOR/DOR agonist activity.

Nanoscale interfacial engineering enables highly stable and efficient perovskite photovoltaics

The molecular level interface engineering with a multifunctional ligand 2,5-thiophenedicarboxylic acid suppresses interfacial ion diffusion and inhibits I2 formation, which leads to high operational stability with T80 of 3570 h along with PCE of 23.4%.

Methylene blue as a far-red light-mediated photocleavable multifunctional ligand

Methylene blue (MB) was discovered as a multifunctional far-red photocleavable ligand capable of rendering a series of MB conjugated compounds with off-to-on fluorescence switch, photodynamic therapy and triggered release of conjugated molecule.

Synthesis, characterization and antimicrobial activities of 1,5-dimethyl-2-phenyl-4-(pyrolidin-2-ylideneamino)-pyrazolidin-3-one and complex with iron(II)

A multifunctional ligand derivative of pyrrolidone has been synthesized by condensation reaction between 4-aminoantipyrine and 2-pyrrolidinone. The ligand and its Iron(II) complex were characterized using physical method and UV and IR techniques. The ligand and Fe(II) complex were tested against broad spectrums of bacterial organisms and the results show that both the ligand and complex were active against various organisms tested.

Metalloligand Strategies for Assembling Heteronuclear Nanocages – Recent Developments

The use of metalloligands as building blocks for the assembly of metallo-organic cages has received increasing attention over the past two decades or so. In part, the popularity of this approach reflects its stepwise nature that lends itself to the predesigned construction of metallocages and especially heteronuclear metallocages. The focus of the present discussion is on the use of metalloligands for the construction of discrete polyhedral cages, very often incorporating heterometal ions as structural elements. The metalloligand approach uses metal-bound multifunctional ligand building blocks that display predesigned structural properties for coordination to a second metal ion such that the rational design and construction of both homo- and heteronuclear metal–organic cages are facilitated. The present review covers published literature in the area from early 2015 to early 2019.