Capillary Driven Muilti Channels Microfluidic

The paper present design and fabrication of capillary driven muilti channels microfluidic. AutoCAD assisted layout design was conducted and fabricated based on cold photolithography process with precise geometry for capillary flow. The design was bonded with glass to test the flow and bonding integrity. The device was tested for flow and it was found the uniform capillary flow was established with strong bonding energy.

Negative Bias Instability of InZnO-Based Thin-Film Transistors Under Illumination Stress

In this study, we investigated the threshold voltage (Vth) instability of solution-processed indium zinc oxide (IZO) thin film transistors (TFTs) prior to and after negative bias illumination stress (NBIS) with varying carrier suppressors (Ga, Al, Hf, and Zr). Variations in electrical properties of the IZO-based TFTs as a function of carrier suppressors were attributed to the differences in metal-oxygen bonding energy of the materials, which was numerically verified by calculating the relative oxygen deficient ratio from the X-ray photoelectron spectroscopy analysis. Furthermore, the values of Vth shift (ΔVth) of the devices subjected to negative gate bias stress under 635 nm (red), 530 nm (green), and 480 nm (blue) wavelength light irradiation increased as the incident photon energy increased. IZO TFTs doped with Ga atoms demonstrated weaker metal-oxygen bonding energy compared to the others and exhibited the largest ΔVth. This result was attributed to the suppressor-dependent distribution of neutral oxygen vacancies which determine the degrees of photon energy absorption in the IZO films. Then, the ΔVth instability of IZO-based TFTs under NBIS correlated well with a stretched exponential function.

Screening and Identification of Potential iNOS Inhibitors to Curtail Cervical Cancer Progression: An in-Silico Drug Repurposing Approach

Cervical cancer is the second most common cause of cancer deaths in women worldwide and remains the main reason of mortality amongst women of reproductive age in developing countries. Nitric oxide is involved in several physiological functions inclusive of inflammatory and immune responses. However, the function of NO in tumor biology is debatable. The inducibleNOS (iNOS/NOS2) isoform is the oneresponsible to maintain the levels of NO and it exhibits pleotropic effects in various cancer with concentration-dependent pro- and anti-tumor effects.NOS2 triggers angiogenesis and endothelial cell migration in tumors by regulating the levels of vascular endothelial growth factor (VEGF). In drug discovery, drug repurposing involves investigations of approved drug candidates to treat various other diseases. In this study, we used FDA-approved anti-cancer drugs and small molecules to target iNOS and identify a potential selective iNOS inhibitor. The structures of ligands were geometrically optimized, and energy minimized using Hyperchem software. Molecular docking was performed using Molegro virtual docker and ligands were selected based on MolDock score,Rerank score, and H-bonding energy. In the study showed 4 compounds, Degarelix, Goserelin, Triptorelin pamoate, and venetoclax demonstrated excellent binding affinity to NOS2 protein. These compounds exhibited the lowest MolDock score, Rerank score, with better H-bonding energy to NOS2. Based on the results theses ligands project to be promising potential NOS2 inhibitors to curtail cervical cancer progression

Imaging Wavefunctions

The concept of wavefunction was introduced in the first 1926 paper by Erwin Schrödinger as the central object of the atomic world and the cornerstone of quantum mechanics. It is a mathematical representation of de Broglie’s postulate that the electron is a material wave. It was defined as everywhere real, single-valued, finite, and continuously differentiable up to the second order. Nevertheless, for many decades, wavefunction has not been characterized as an observable. First, it is too small. The typical size is a small fraction of a nanometer. Second, it is too fragile. The typical bonding energy of a wavefunction is a few electron volts. The advancement of STM and AFM has made wavefunctions observable. The accuracy of position measurement is in picometers. Both STM and AFM measurements are non-destructive, which leaves the wavefunctions under observation undisturbed. Finally, the meaning of direct experimental7 observation and mapping of wavefunctions is discussed.

Sulfur promotes hydrogen evolution on molybdenum carbide catalysts

We report that sulfur-doping of molybdenum carbide catalysts produces a good hydrogen evolution electrocatalyst. The doped sulfur atoms weaken the hydrogen bonding energy, enhancing the catalyst's activity in hydrogen evolution.